Glanzmann's thrombasthenia history and symptoms: Difference between revisions
No edit summary |
No edit summary |
||
| Line 7: | Line 7: | ||
==History== | ==History== | ||
History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia. | |||
GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. <ref name="pmid26185478">{{cite journal| author=Solh T, Botsford A, Solh M| title=Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. | journal=J Blood Med | year= 2015 | volume= 6 | issue= | pages= 219-27 | pmid=26185478 | doi=10.2147/JBM.S71319 | pmc=4501245 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26185478 }}</ref> The severity of the presenting symptoms has no known relation to the affected gene. | |||
==Symptoms== | ==Symptoms== | ||
Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage | Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage | ||
It may include any of the following | It may include any of the following manifestation: | ||
* Bruising easily | * Bruising easily (76.6%) | ||
* Nosebleeds that do not stop easily | * Nosebleeds that do not stop easily (62.5%) | ||
* Bleeding gums | * Bleeding gums (56.4%) | ||
* Prolonged bleeding with minor injuries | * Prolonged bleeding with minor injuries (47.2%) | ||
* Heavy menstrual bleeding | * Heavy menstrual bleeding | ||
* postpartum bleeding | * postpartum bleeding | ||
* gastrointestinal bleeding | * gastrointestinal bleeding | ||
* Heavy bleeding during and after surgery | * Heavy bleeding during and after surgery | ||
* bleeding into joints (rare) | * bleeding into joints (rare) <ref name="pmid27539755">{{cite journal| author=Iqbal I, Farhan S, Ahmed N| title=Glanzmann Thrombasthenia: A Clinicopathological Profile. | journal=J Coll Physicians Surg Pak | year= 2016 | volume= 26 | issue= 8 | pages= 647-50 | pmid=27539755 | doi=2396 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27539755 }}</ref> | ||
==References== | ==References== | ||
Revision as of 09:48, 6 July 2018
|
Glanzmann's thrombasthenia |
|
Differentiating Glanzmann's thrombasthenia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Glanzmann's thrombasthenia history and symptoms On the Web |
|
American Roentgen Ray Society Images of Glanzmann's thrombasthenia history and symptoms |
|
Risk calculators and risk factors for Glanzmann's thrombasthenia history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History
History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia.
GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. [1] The severity of the presenting symptoms has no known relation to the affected gene.
Symptoms
Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage
It may include any of the following manifestation:
- Bruising easily (76.6%)
- Nosebleeds that do not stop easily (62.5%)
- Bleeding gums (56.4%)
- Prolonged bleeding with minor injuries (47.2%)
- Heavy menstrual bleeding
- postpartum bleeding
- gastrointestinal bleeding
- Heavy bleeding during and after surgery
- bleeding into joints (rare) [2]
References
- ↑ Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.
- ↑ Iqbal I, Farhan S, Ahmed N (2016). "Glanzmann Thrombasthenia: A Clinicopathological Profile". J Coll Physicians Surg Pak. 26 (8): 647–50. doi:2396 Check
|doi=value (help). PMID 27539755.