Glanzmann's thrombasthenia history and symptoms: Difference between revisions
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History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia. | History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia. | ||
GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. <ref name="pmid26185478">{{cite journal| author=Solh T, Botsford A, Solh M| title=Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. | journal=J Blood Med | year= 2015 | volume= 6 | issue= | pages= 219-27 | pmid=26185478 | doi=10.2147/JBM.S71319 | pmc=4501245 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26185478 }}</ref> The severity of the presenting symptoms has no known relation to the affected gene. | GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. <ref name="pmid26185478">{{cite journal| author=Solh T, Botsford A, Solh M| title=Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. | journal=J Blood Med | year= 2015 | volume= 6 | issue= | pages= 219-27 | pmid=26185478 | doi=10.2147/JBM.S71319 | pmc=4501245 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26185478 }}</ref> The severity of the presenting symptoms has no known relation to the affected gene. However mutations in the ITGB3 gene manifest bleeding more than the other gene .<ref name="pmid22781097">{{cite journal| author=Fiore M, Nurden AT, Nurden P, Seligsohn U| title=Clinical utility gene card for: Glanzmann thrombasthenia. | journal=Eur J Hum Genet | year= 2012 | volume= 20 | issue= 10 | pages= | pmid=22781097 | doi=10.1038/ejhg.2012.151 | pmc=3449071 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22781097 }}</ref> | ||
==Symptoms== | ==Symptoms== | ||
Revision as of 09:17, 9 July 2018
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Glanzmann's thrombasthenia |
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Differentiating Glanzmann's thrombasthenia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History
History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia.
GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. [1] The severity of the presenting symptoms has no known relation to the affected gene. However mutations in the ITGB3 gene manifest bleeding more than the other gene .[2]
Symptoms
Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage
It may include any of the following manifestation:
- Bruising easily (76.6%)
- Nosebleeds that do not stop easily (62.5%)
- Bleeding gums (56.4%)
- Prolonged bleeding with minor injuries (47.2%)
- Heavy menstrual bleeding
- postpartum bleeding
- gastrointestinal bleeding
- Heavy bleeding during and after surgery
- bleeding into joints (rare) [3]
References
- ↑ Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.
- ↑ Fiore M, Nurden AT, Nurden P, Seligsohn U (2012). "Clinical utility gene card for: Glanzmann thrombasthenia". Eur J Hum Genet. 20 (10). doi:10.1038/ejhg.2012.151. PMC 3449071. PMID 22781097.
- ↑ Iqbal I, Farhan S, Ahmed N (2016). "Glanzmann Thrombasthenia: A Clinicopathological Profile". J Coll Physicians Surg Pak. 26 (8): 647–50. doi:2396 Check
|doi=value (help). PMID 27539755.