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*Multiple myeloma is the second most common hematologic malignancy, after [[non-Hodgkin lymphoma]].<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*Multiple myeloma is the second most common hematologic malignancy, after [[non-Hodgkin lymphoma]].<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*Since 1975, the overall multiple myeloma incidence has increased nearly 1 percent annually.<ref name="snap">A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015</ref>
*Since 1975, the overall multiple myeloma incidence has increased nearly 1 percent annually.<ref name="snap">A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015</ref>
*Solitary plasmacytoma accounts for approximately 5% of plasma cell neoplasms.<ref name="pmid26464186">{{cite journal| author=Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z| title=Surgery combined with radiotherapy for the treatment of solitary plasmacytoma of the rib: a case report and review of the literature. | journal=J Cardiothorac Surg | year= 2015 | volume= 10 | issue=  | pages= 125 | pmid=26464186 | doi=10.1186/s13019-015-0335-5 | pmc=4605096 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26464186  }} </ref>
*The incidence of solitary plasmacytoma in males to females is 2:1.<ref name="pmid26464186">{{cite journal| author=Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z| title=Surgery combined with radiotherapy for the treatment of solitary plasmacytoma of the rib: a case report and review of the literature. | journal=J Cardiothorac Surg | year= 2015 | volume= 10 | issue=  | pages= 125 | pmid=26464186 | doi=10.1186/s13019-015-0335-5 | pmc=4605096 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26464186  }} </ref>


===Prevalance===
===Prevalance===

Revision as of 00:07, 22 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]

Overview

In 2012, the incidence of multiple myeloma was approximately 6.3 per 100,000 cases with a mortality rate of 3.3 per 100,000 cases in the United States.[1] The prevalence of multiple myeloma was estimated to be 89,658 cases in 2012 in the United States.[2][3] Multiple myeloma is the second most common blood cancer after non-Hodgkin's lymphoma and 14th most common cancer overall in United States.[4][2][3] Males are more commonly affected with multiple myeloma than females; the male to female ratio is approximately 1.54 to 1.[3][5] Multiple myeloma usually affects individuals of the African American and Native Pacific Islanders race. Asian individuals are less likely to develop multiple myeloma.[3] The incidence of multiple myeloma increases with age; the median age at diagnosis is approximately 66–70 years with 37% of patients being younger than 65 years of age.PMID: 28061985

Epidemiology and Demographics

Incidence

  • The age-standardized incidence rate of multiple myeloma worldwide is 1.5 per 100,000 persons per year.[6]
  • In 2012, the incidence of multiple myeloma waws approximately 6.3 per 100,000 individuals with a case-fatality rate of 3.3 per 100,000 in the United States.[1]
  • In 2014, multiple myeloma constituted approximately 1.4 percent of the estimated new cancer cases.[7]
  • In 2015, the estimated incidence of multiple myeloma is 1.6% of all new cancer cases and 1.9% of all cancer mortality cases.[2]
  • Multiple myeloma is the 14th leading cause of cancer death in the United States.[2]
  • Multiple myeloma is the second most common hematologic malignancy, after non-Hodgkin lymphoma.[6]
  • Since 1975, the overall multiple myeloma incidence has increased nearly 1 percent annually.[7]
  • Solitary plasmacytoma accounts for approximately 5% of plasma cell neoplasms.[8]
  • The incidence of solitary plasmacytoma in males to females is 2:1.[8]

Prevalance

  • Myeloma is the 14th leading cause of cancer death in the United States.[2]
  • [9]Multiple myeloma accounts for around 1% of all cancers worldwide and is the second most prevalent hematological neoplasm (10–15%) after non-Hodgkin's lymphoma.[4][2]PMID:27476706/PMID:24614435
  • There are approximately 76,000 people in the United States living with multiple myeloma.[2]
  • In 2012, there were an estimated 89,658 people living with multiple myeloma in the United States.[2]

Age

  • The incidence of multiple myeloma increases with age, and the the median age at diagnosis is 65 to 70 years.[6]

Gender

  • Males are more commonly affected with multiple myeloma than females. The male to female ratio is approximately 1.54 to 1.[5]

Race

  • Among African Americans, multiple myeloma is one of the top 10 leading causes of cancer deaths.[2]
  • The incidence of multiple myeloma in the African American population is more than the European American population.
  • African Americans have a 2-fold higher age-standardized incidence rate of multiple myeloma than Caucasians.[6] The incidence of multiple myeloma in African Americans is 9.6 per 100,000 persons. The incidence of Caucasians is 4.1 per 100,000 persons.[6]

Gallery

Multiple myeloma summary.[2]


Percent of new cases by age group: multiple myeloma.[2]


Number of new cases per 100,000 persons by race/ethnicity & sex: multiple myeloma.[2]>


Percent of deaths per age group: multiple myeloma.[2]


Number of deaths per 100,000 persons by race/ethnicity & sex multiple myeloma.[2]


Multiple myeloma percent of total new cancer csases in the United states.[2]


Five year survival percentage.[2]


New cases, deaths, and 5-Year relative survival.[2]

References

  1. ↑ 1.0 1.1 Plasma cell neoplasm.National cancer institute (2015)http://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq#cit/section_1.1 Accessed on September, 20th 2015
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015
  3. ↑ 3.0 3.1 3.2 3.3 Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September, 20th 2015
  4. ↑ 4.0 4.1 Collins, CD. (2005). "Problems monitoring response in multiple myeloma". Cancer Imaging. 5 Spec No A: S119–26. doi:10.1102/1470-7330.2005.0033. PMID 16361127.
  5. ↑ 5.0 5.1 Multiple myeloma. Radiopaedia (2015)http://radiopaedia.org/articles/multiple-myeloma-1 Accessed on September, 20th 2015
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Hong J, Lee JH (2016). "Recent advances in multiple myeloma: a Korean perspective". Korean J Intern Med. 31 (5): 820–34. doi:10.3904/kjim.2015.408. PMC 5016289. PMID 27604794.
  7. ↑ 7.0 7.1 A snapshot of myeloma. National cancer institute(2014)http://www.cancer.gov/research/progress/snapshots/myeloma Accessed on September, 20th 2015
  8. ↑ 8.0 8.1 Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z (2015). "Surgery combined with radiotherapy for the treatment of solitary plasmacytoma of the rib: a case report and review of the literature". J Cardiothorac Surg. 10: 125. doi:10.1186/s13019-015-0335-5. PMC 4605096. PMID 26464186.
  9. ↑ Seer stat fact sheet. National cancer institute (2015)http://seer.cancer.gov/statfacts/html/mulmy.html Accessed on September, 20th 2015

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