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*However, it is thought that hyperfiltration through the renal glomeruli may be responsible for the manifestations of the disease.<ref name="pmid14684674">{{cite journal |vauthors=Ziyadeh FN |title=Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator |journal=J. Am. Soc. Nephrol. |volume=15 Suppl 1 |issue= |pages=S55–7 |date=January 2004 |pmid=14684674 |doi= |url=}}</ref> | *However, it is thought that hyperfiltration through the renal glomeruli may be responsible for the manifestations of the disease.<ref name="pmid14684674">{{cite journal |vauthors=Ziyadeh FN |title=Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator |journal=J. Am. Soc. Nephrol. |volume=15 Suppl 1 |issue= |pages=S55–7 |date=January 2004 |pmid=14684674 |doi= |url=}}</ref> | ||
*The hyperglycemia in uncontrolled diabetics may increase the expression of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF), leading to glomerular hypercellularity. | *The hyperglycemia in uncontrolled diabetics may increase the expression of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF), leading to glomerular hypercellularity. | ||
*The occurrence of diabetic nephropathy may be attributed to a genetic factor as it is more common in certain ethnicities. | *The occurrence of diabetic nephropathy may be attributed to a genetic factor as it is more common in certain ethnicities. | ||
*Certain polymorphism in the angiotensin-converting enzyme has been associated with the development of diabetic nephropathy.<ref name="pmid20057426">{{cite journal |vauthors=Rask-Madsen C, King GL |title=Kidney complications: factors that protect the diabetic vasculature |journal=Nat. Med. |volume=16 |issue=1 |pages=40–1 |date=January 2010 |pmid=20057426 |doi=10.1038/nm0110-40 |url=}}</ref> | |||
*A recent study has shown an association between folic acid deficiency and the development of diabetic nephropathy.<ref name="pmid19452424">{{cite journal |vauthors=Chiarelli F, Gaspari S, Marcovecchio ML |title=Role of growth factors in diabetic kidney disease |journal=Horm. Metab. Res. |volume=41 |issue=8 |pages=585–93 |date=August 2009 |pmid=19452424 |doi=10.1055/s-0029-1220752 |url=}}</ref> | *A recent study has shown an association between folic acid deficiency and the development of diabetic nephropathy.<ref name="pmid19452424">{{cite journal |vauthors=Chiarelli F, Gaspari S, Marcovecchio ML |title=Role of growth factors in diabetic kidney disease |journal=Horm. Metab. Res. |volume=41 |issue=8 |pages=585–93 |date=August 2009 |pmid=19452424 |doi=10.1055/s-0029-1220752 |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
The exact cause of diabetic nephropathy is unknown. However, it is thought that hyperfiltration through the renal glomeruli may be responsible for the manifestations of the disease.
Causes
- The exact cause of diabetic nephropathy is unknown.
- However, it is thought that hyperfiltration through the renal glomeruli may be responsible for the manifestations of the disease.[1]
- The hyperglycemia in uncontrolled diabetics may increase the expression of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF), leading to glomerular hypercellularity.
- The occurrence of diabetic nephropathy may be attributed to a genetic factor as it is more common in certain ethnicities.
- Certain polymorphism in the angiotensin-converting enzyme has been associated with the development of diabetic nephropathy.[2]
- A recent study has shown an association between folic acid deficiency and the development of diabetic nephropathy.[3]
References
- ↑ Ziyadeh FN (January 2004). "Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator". J. Am. Soc. Nephrol. 15 Suppl 1: S55–7. PMID 14684674.
- ↑ Rask-Madsen C, King GL (January 2010). "Kidney complications: factors that protect the diabetic vasculature". Nat. Med. 16 (1): 40–1. doi:10.1038/nm0110-40. PMID 20057426.
- ↑ Chiarelli F, Gaspari S, Marcovecchio ML (August 2009). "Role of growth factors in diabetic kidney disease". Horm. Metab. Res. 41 (8): 585–93. doi:10.1055/s-0029-1220752. PMID 19452424.