Interstitial nephritis natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
Line 31: Line 31:
* Renal failure lasts for >3 weeks.<ref>Ditlove J, Weidmann P, Bernstein M, Massry SG. Methicillin nephritis. Med Balt  1977; 56: 483–491</ref><ref>Laberke HG, Bohle A. Acute interstitial nephritis: correlations between clinical and morphological findings. Clin Nephrol  1980; 14: 263–273</ref>  <ref />
* Renal failure lasts for >3 weeks.<ref>Ditlove J, Weidmann P, Bernstein M, Massry SG. Methicillin nephritis. Med Balt  1977; 56: 483–491</ref><ref>Laberke HG, Bohle A. Acute interstitial nephritis: correlations between clinical and morphological findings. Clin Nephrol  1980; 14: 263–273</ref>  <ref />
* Older patients<ref>Kida H, Abe T, Tomosugi N et al. Prediction of the long-term outcome in acute interstitial nephritis. Clin Nephrol  1984; 22: 55–60</ref>
* Older patients<ref>Kida H, Abe T, Tomosugi N et al. Prediction of the long-term outcome in acute interstitial nephritis. Clin Nephrol  1984; 22: 55–60</ref>
* Presence of tubular atrophy and interstitial fibrosis in the renal biopsy.<ref />Kida H, Abe T, Tomosugi N et al. Prediction of the long-term outcome in acute interstitial nephritis. Clin Nephrol  1984; 22: 55–60<ref /> <ref>Bhaumik SK, Kher V, Arora P et al. Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis. Ren Fail  1996; 18: 97–104</ref>  
* Presence of tubular atrophy and interstitial fibrosis in the renal biopsy.<ref /> <ref>Bhaumik SK, Kher V, Arora P et al. Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis. Ren Fail  1996; 18: 97–104</ref>  
In chronic tubulointerstitial nephritis the most serious long term effect is [[kidney failure]].  When the proximal tubule is injured sodium, potassium, bicarbonate, uric acid, and phosphate intake may be reduced or changed, resulting in  [[metabolic acidosis]], [[hypokalemia]], [[hypouricemia]], [[hypophosphatemia]].  Damage to the distal renal tubule may cause loss of urine concentrating ability and [[polyuria]].


==References==
==References==

Revision as of 23:53, 19 July 2018


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [[1]]; Associate Editor(s)-in-Chief:Mohsen Basiri M.D.

Overview

In the majority of patients with TIN, recovery of renal function has been observed, and improvement immediately occurs upon stopping the offensive agent.

Nevertheless, about 12% of patients may progress to develop ESRD and its complications; and thus require dialysis or transplantation.

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
  • The symptoms of (disease name) typically develop ___ years after exposure to ___.
  • If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

Prognosis

In the majority of patients with TIN, a full recovery or partial recovery occurs upon stopping the offensive agent. Meanwhile,about 12% of patients may progress to ESRD and its complications; and thus require dialysis or transplantation.[1]

It has been suggested that the long-term prognosis is worse if:

  • Renal failure lasts for >3 weeks.[2][3]
  • Older patients[4]
  • Presence of tubular atrophy and interstitial fibrosis in the renal biopsy. [5]

References

  1. ↑ Baker, R. J.; Pusey, C. D. (2004). "The changing profile of acute tubulointerstitial nephritis". Nephrology Dialysis Transplantation. 19 (1): 8–11. doi:10.1093/ndt/gfg464. ISSN 0931-0509.
  2. ↑ Ditlove J, Weidmann P, Bernstein M, Massry SG. Methicillin nephritis. Med Balt 1977; 56: 483–491
  3. ↑ Laberke HG, Bohle A. Acute interstitial nephritis: correlations between clinical and morphological findings. Clin Nephrol 1980; 14: 263–273
  4. ↑ Kida H, Abe T, Tomosugi N et al. Prediction of the long-term outcome in acute interstitial nephritis. Clin Nephrol 1984; 22: 55–60
  5. ↑ Bhaumik SK, Kher V, Arora P et al. Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis. Ren Fail 1996; 18: 97–104

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Interstitial_nephritis_natural_history,_complications_and_prognosis&oldid=1483904"