Membranous glomerulonephritis natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
The symptoms of membranous glomerulonephritis usually develop in the fourth decade of life in males. Common complications of membranous glomerulonephritis include [[renal failure]]. The prognosis is | The symptoms of membranous glomerulonephritis usually develop in the fourth decade of life in males. Approximately 5-30% patients with MN have spontanous remission. Common complications of membranous glomerulonephritis include [[renal failure]],[[Hypertension]], [[Proteinuria]], [[Dyslipidemia]], [[Hypercoagulable state]] leading to [[thromboembolism]], Increased risk of [[infection]]. Prognosis is generally good, and 1 year [[mortality rate]] of patients with membranous glomerulonephritis is approximately 0.38%. The presence of [[proteinuria]] and baseline [[renal insuffiency]] are associated with a particularly poor prognosis among patients with membranous glomerulonephritis. Membranous glomerulonephritis caused by [[NSAIDS]] is associated with the most favorable prognosis. | ||
==Natural History== | ==Natural History== | ||
Revision as of 14:00, 25 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]
Overview
The symptoms of membranous glomerulonephritis usually develop in the fourth decade of life in males. Approximately 5-30% patients with MN have spontanous remission. Common complications of membranous glomerulonephritis include renal failure,Hypertension, Proteinuria, Dyslipidemia, Hypercoagulable state leading to thromboembolism, Increased risk of infection. Prognosis is generally good, and 1 year mortality rate of patients with membranous glomerulonephritis is approximately 0.38%. The presence of proteinuria and baseline renal insuffiency are associated with a particularly poor prognosis among patients with membranous glomerulonephritis. Membranous glomerulonephritis caused by NSAIDS is associated with the most favorable prognosis.
Natural History
- The natural history of membranous glomerulonephritis (MN) is given below:[1][2]
- The symptoms of MN usually develop in the fourth decade of life in males.
- The presence of symptoms of MN young female is suggestive of lupus.
- Approximately 5-30% patients with MN have spontanous remission.
Complications
- Common complications of membranous glomerulonepharitis include:[3][4]
- Renal failure
- Symptoms associated with the nephrotic syndrome:
- Hypercoagulable state leading to thromboembolism
- Increased risk of infection
Prognosis
- The prognostic factors of membranous glomerulonephritis are given below:[5][6]
- Prognosis is generally good, and 1 year mortality rate of patients with membranous glomerulonephritis is approximately 0.38%.
- Depending on the extent of the membranous glomerulonephritis at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
- The presence of proteinuria and baseline renal insuffiency are associated with a particularly poor prognosis among patients with membranous glomerulonephritis.
- Membranous glomerulonephritis caused by NSAIDS is associated with the most favorable prognosis.
- The prognosis of membranous glomerulonephritis associated with hepatitis B has less favorable prognosis.
References
- ↑ Kerjaschki D (2000). "Pathogenetic concepts of membranous glomerulopathy (MGN)". J. Nephrol. 13 Suppl 3: S96–100. PMID 11132040.
- ↑ Schieppati A, Mosconi L, Perna A, Mecca G, Bertani T, Garattini S, Remuzzi G (July 1993). "Prognosis of untreated patients with idiopathic membranous nephropathy". N. Engl. J. Med. 329 (2): 85–9. doi:10.1056/NEJM199307083290203. PMID 8510707.
- ↑ Debiec H, Ronco P (July 2014). "Immunopathogenesis of membranous nephropathy: an update". Semin Immunopathol. 36 (4): 381–97. doi:10.1007/s00281-014-0423-y. PMID 24715030.
- ↑ Barbour S, Reich H, Cattran D (2013). "Short-term complications of membranous nephropathy". Contrib Nephrol. 181: 143–51. doi:10.1159/000349976. PMID 23689576.
- ↑ Wasserstein AG (April 1997). "Membranous glomerulonephritis". J. Am. Soc. Nephrol. 8 (4): 664–74. PMID 10495797.
- ↑ McGrogan, A.; Franssen, C. F. M.; de Vries, C. S. (2010). "The incidence of primary glomerulonephritis worldwide: a systematic review of the literature". Nephrology Dialysis Transplantation. 26 (2): 414–430. doi:10.1093/ndt/gfq665. ISSN 0931-0509.