Idiopathic thrombocytopenic purpura history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
ITP is | ITP is chronic in adults<ref name="pmid11919310">{{cite journal |author=Cines DB, Blanchette VS |title=Immune thrombocytopenic purpura |journal=N. Engl. J. Med. |volume=346 |issue=13 |pages=995-1008 |year=2002 |pmid=11919310 |doi=10.1056/NEJMra010501}}</ref> and the probability of remission is 20–40%.<ref name="pmid17122451">{{cite journal |author=Stevens W, Koene H, Zwaginga JJ, Vreugdenhil G |title=Chronic idiopathic thrombocytopenic purpura: present strategy, guidelines and new insights |journal=The Netherlands journal of medicine |volume=64 |issue=10 |pages=356-63 |year=2006 |pmid=17122451 |doi=}}</ref> , ITP patients suffer from [[bruising]], [[petechia]]e, [[nosebleed]]s and bleeding [[gums]] may occur if the platelet count is below 20,000,<ref name="pmid15660520">{{cite journal |author=Cines DB, McMillan R |title=Management of adult idiopathic thrombocytopenic purpura |journal=Annu. Rev. Med. |volume=56 |issue= |pages=425-42 |year=2005 |pmid=15660520 |doi=10.1146/annurev.med.56.082103.104644}}</ref> compared to a normal range of 150,000–400,000 per mm<sup>3</sup>. | ||
[[Evans syndrome]] can occur in ~1% of cases and manifests by an autoimmune (Coombs +) hemolytic anemia with ITP. | [[Evans syndrome]] can occur in ~1% of cases and manifests by an autoimmune (Coombs +) hemolytic anemia with ITP. | ||
Latest revision as of 15:51, 28 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
ITP is chronic in adults[1] and the probability of remission is 20–40%.[2] , ITP patients suffer from bruising, petechiae, nosebleeds and bleeding gums may occur if the platelet count is below 20,000,[3] compared to a normal range of 150,000–400,000 per mm3.
Evans syndrome can occur in ~1% of cases and manifests by an autoimmune (Coombs +) hemolytic anemia with ITP.
Symptoms include:
- Abnormally heavy menstruation
- Bleeding into the skin causing a characteristic skin rash that looks like pinpoint red spots (petechial rash), purpura
- Easy bruising
- Nosebleed or bleeding in the mouth
- intracranial hemorrhage
References
- ↑ Cines DB, Blanchette VS (2002). "Immune thrombocytopenic purpura". N. Engl. J. Med. 346 (13): 995–1008. doi:10.1056/NEJMra010501. PMID 11919310.
- ↑ Stevens W, Koene H, Zwaginga JJ, Vreugdenhil G (2006). "Chronic idiopathic thrombocytopenic purpura: present strategy, guidelines and new insights". The Netherlands journal of medicine. 64 (10): 356–63. PMID 17122451.
- ↑ Cines DB, McMillan R (2005). "Management of adult idiopathic thrombocytopenic purpura". Annu. Rev. Med. 56: 425–42. doi:10.1146/annurev.med.56.082103.104644. PMID 15660520.