Bleeding diathesis: Difference between revisions
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{{Bleeding diathesis}} | {{Bleeding diathesis}} | ||
{{CMG}}; {{MJ}} | {{CMG}}; {{MJ}} | ||
== Overview == | |||
== Classification == | |||
== Differential Diagnosis == | |||
{| class="wikitable" | |||
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| rowspan="8" |Platelet disorders | |||
| rowspan="7" |Thrombocytopenia | |||
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==== Infection-Induced Thrombocytopenia ==== | |||
<span name="harr_c115s002s001s002p001"></span><span name="9100754"></span> | |||
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==== Drug-Induced Thrombocytopenia ==== | |||
<span name="harr_c115s002s001s003p001"></span><span name="9100757"></span> | |||
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==== Heparin-Induced Thrombocytopenia ==== | |||
<span name="harr_c115s002s001s004p001"></span><span name="9100761"></span> | |||
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==== Immune Thrombocytopenic Purpura (ITP) ==== | |||
<span name="harr_c115s002s001s005p001"></span><span name="9100771"></span> | |||
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==== Inherited Thrombocytopenia ==== | |||
<span name="harr_c115s002s001s006p001"></span><span name="9100783"></span> | |||
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==== Thrombotic Thrombocytopenic Purpura (TTP) ==== | |||
<span name="harr_c115s002s002s001p001"></span><span name="9100787"></span> | |||
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==== Hemolytic Uremic Syndrome ==== | |||
<span name="harr_c115s002s002s002p001"></span><span name="9100796"></span> | |||
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=== Thromobcytosis === | |||
<span name="harr_c115s002s003p001"></span><span name="9100800"></span> | |||
|Thrombocytosis in response to acute or chronic inflammation has not been associated with an increased thrombotic risk. In fact, patients with markedly elevated platelet counts (>1.5 million), usually seen in the setting of a myeloproliferative disorder, have an increased risk of bleeding. This appears to be due, at least in part, to acquired von Willebrand disease (VWD) due to platelet-VWF adhesion and removal. | |||
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==== Qualitative Disorders of Platelet Function ==== | |||
<span name="harr_c115s002s004s001p001"></span><span name="9100803"></span> | |||
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==== Inherited Disorders of Platelet Function ==== | |||
<span name="harr_c115s002s004s001p001"></span><span name="9100803"></span> | |||
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==== Acquired Disorders of Platelet Function ==== | |||
<span name="harr_c115s002s004s002p001"></span><span name="9100808"></span> | |||
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=== von Willebrand Disease === | |||
<span name="harr_c115s002s005p001"></span><span name="9100810"></span> | |||
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| rowspan="2" |Vessel wall disorders | |||
|Metabolic and Inflammatory Disorders | |||
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|Inherited Disorders of the Vessel Wall | |||
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| rowspan="12" |Coagulation disorders | |||
|Fibrinogen | |||
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|Prothrombin | |||
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| rowspan="1" |Factor V | |||
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| rowspan="1" |Factor VII | |||
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| rowspan="1" |Factor VIII | |||
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| rowspan="1" |Factor IX | |||
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| rowspan="1" |Factor X | |||
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| rowspan="1" |Factor XI | |||
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| rowspan="1" |Factor XII | |||
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|HK | |||
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| rowspan="1" |Prekallikrein | |||
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| rowspan="1" |Factor XIII | |||
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| rowspan="3" |[[Hemophilia]] | |||
|Type A | |||
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|Type B | |||
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|Type C | |||
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| rowspan="4" |Rare diseases | |||
|Disseminated Intravascular Coagulation | |||
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|Vitamin K Deficiency | |||
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|Coagulation Disorders Associated with Liver Failure | |||
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|Acquired Inhibitors of Coagulation Factors | |||
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Revision as of 16:54, 6 August 2018
Bleeding diathesis main page |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mehrian Jafarizade, M.D [2]
Overview
Classification
Differential Diagnosis
Platelet disorders | Thrombocytopenia |
Infection-Induced Thrombocytopenia
|
|
Drug-Induced Thrombocytopenia
|
|||
Heparin-Induced Thrombocytopenia
|
|||
Immune Thrombocytopenic Purpura (ITP)
|
|||
Inherited Thrombocytopenia
|
|||
Thrombotic Thrombocytopenic Purpura (TTP)
|
|||
Hemolytic Uremic Syndrome
|
|||
Thromobcytosis
|
Thrombocytosis in response to acute or chronic inflammation has not been associated with an increased thrombotic risk. In fact, patients with markedly elevated platelet counts (>1.5 million), usually seen in the setting of a myeloproliferative disorder, have an increased risk of bleeding. This appears to be due, at least in part, to acquired von Willebrand disease (VWD) due to platelet-VWF adhesion and removal. | ||
Qualitative Disorders of Platelet Function
|
Inherited Disorders of Platelet Function
|
||
Acquired Disorders of Platelet Function
|
|||
von Willebrand Disease
|
|||
Vessel wall disorders | Metabolic and Inflammatory Disorders | ||
Inherited Disorders of the Vessel Wall | |||
Coagulation disorders | Fibrinogen | ||
Prothrombin | |||
Factor V | |||
Factor VII | |||
Factor VIII | |||
Factor IX | |||
Factor X | |||
Factor XI | |||
Factor XII | |||
HK | |||
Prekallikrein | |||
Factor XIII | |||
Hemophilia | Type A | ||
Type B | |||
Type C | |||
Rare diseases | Disseminated Intravascular Coagulation | ||
Vitamin K Deficiency | |||
Coagulation Disorders Associated with Liver Failure | |||
Acquired Inhibitors of Coagulation Factors |