Glucose-6-phosphate dehydrogenase deficiency risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

There are no established risk factors for [disease name].

OR

The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.

Risk Factors

The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Common Risk Factors

• Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
• Common risk factors in the development of G6PD include:
  • Foods such as fava beans in G6PD mutation carriers
  • Medications such as:
    • Aspirin,
    • Antimalarials: quinine, primaquine, pamaquine, and chloroquine
    • Sulfonamides: mafenide, sulfanilamide, sulfamethoxazole
    • Thiazolesulfone
    • Methylene blue,
    • Naphthalene
    • Analgesics: phenazopyridine and acetanilide
    • Some non-sulfa antibiotics : furazolidone, isoniazid, dapsone, nalidixic acid, nitrofurantoin). Henna has been known to cause hemolytic crisis in G6PD-deficient infants. Rasburicase is also contraindicated in G6PD deficiency. High dose intravenous vitamin C has also been known to cause haemolysis in G6PD deficiency carriers, thus G6PD deficiency testing is routine before infusion of doses of 25g or more.
  • Bacterial or viral infection
  • Some chemicals: Hanna in tattos and hair dyes.

Less Common Risk Factors

• Less common risk factors in the development of G6PD include:
  • Moth balls (naphthalene)
  • Diabetic ketoacidosis

References

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [4]

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Risk Factors

• Ethnic groups
  • African American
  • Middle Eastern decent, particularly Kurdish or Sephardic Jewish
• Male
• Family history of the deficiency

References

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