Multiple myeloma causes: Difference between revisions
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==Causes== | ==Causes== | ||
The causes of multiple myeloma include | ===Common causes=== | ||
The causes of multiple myeloma include: | |||
*Sporadic mutations and genetic predisposition. | |||
*Mutations in tumor suppressors or oncogenes can cause multiple myeloma. | |||
*Mutations in the tumor suppressor ''TP53'' is most common. | |||
*Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.<ref name="pmid27291302">{{cite journal| author=Rajkumar SV| title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. | journal=Am J Hematol | year= 2016 | volume= 91 | issue= 7 | pages= 719-34 | pmid=27291302 | doi=10.1002/ajh.24402 | pmc=5291298 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27291302 }} </ref> | |||
===Less common causes=== | |||
Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.<ref name="pmid27291302">{{cite journal| author=Rajkumar SV| title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. | journal=Am J Hematol | year= 2016 | volume= 91 | issue= 7 | pages= 719-34 | pmid=27291302 | doi=10.1002/ajh.24402 | pmc=5291298 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27291302 }} </ref> | |||
== References == | == References == | ||
Revision as of 21:46, 23 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]
Overview
The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.
Causes
Common causes
The causes of multiple myeloma include:
- Sporadic mutations and genetic predisposition.
- Mutations in tumor suppressors or oncogenes can cause multiple myeloma.
- Mutations in the tumor suppressor TP53 is most common.
- Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.[1]
Less common causes
Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.[1]
References
- ↑ 1.0 1.1 Rajkumar SV (2016). "Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management". Am J Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.