Thrombocytopenia history and symptoms: Difference between revisions
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==History == | ==History == | ||
A thorough history is essential to an effective evaluation of [[thrombocytopenia]]. While some of the conditions leading to [[thrombocytopenia]] can be immediately diagnosed, others may require specific or repeated questioning. In addition to a well-investigated present illness, a precise past medical history can help a great deal to identify the cause of [[thrombocytopenia]]. The history should include questions about:<ref name="pmid24267279">{{cite journal| author=Greenberg EM, Kaled ES| title=Thrombocytopenia. | journal=Crit Care Nurs Clin North Am | year= 2013 | volume= 25 | issue= 4 | pages= 427-34, v | pmid=24267279 | doi=10.1016/j.ccell.2013.08.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24267279 }}</ref> | A thorough history is essential to an effective evaluation of [[thrombocytopenia]]. While some of the conditions leading to [[thrombocytopenia]] can be immediately diagnosed, others may require specific or repeated questioning. In addition to a well-investigated present illness, a precise past medical history can help a great deal to identify the cause of [[thrombocytopenia]]. The history should include questions about:<ref name="pmid24267279">{{cite journal| author=Greenberg EM, Kaled ES| title=Thrombocytopenia. | journal=Crit Care Nurs Clin North Am | year= 2013 | volume= 25 | issue= 4 | pages= 427-34, v | pmid=24267279 | doi=10.1016/j.ccell.2013.08.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24267279 }}</ref><ref name="pmid15481750">{{cite journal| author=Patel U, Gandhi G, Friedman S, Niranjan S| title=Thrombocytopenia in malaria. | journal=J Natl Med Assoc | year= 2004 | volume= 96 | issue= 9 | pages= 1212-4 | pmid=15481750 | doi= | pmc=2568454 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15481750 }}</ref> | ||
* [[Bleeding]] (eg, [[Petechia|petechiae]], [[Ecchymosis|ecchymoses]], [[epistaxis]], [[Gingiva|gingival]] bleeding, [[hematemesis]], [[melena]], [[menorrhagia]]) | * [[Bleeding]] (eg, [[Petechia|petechiae]], [[Ecchymosis|ecchymoses]], [[epistaxis]], [[Gingiva|gingival]] bleeding, [[hematemesis]], [[melena]], [[menorrhagia]]) | ||
* Other symptpms such as [[fever]], [[Rash|rashes]], [[pain]] (eg, in bone), [[headache]], or vision changes | * Other symptpms such as [[fever]], [[Rash|rashes]], [[pain]] (eg, in bone), [[headache]], or vision changes | ||
* Recent travel ([[dengue fever]], [[malaria]], [[rickettsial infections]], [[Tick-borne disease|tick bite]] | * Recent travel ([[dengue fever]], [[malaria]], [[rickettsial infections]], [[Tick-borne disease|tick bite]], [[leptospirosis]], [[meningococcemia]], [[Hantavirus infection|Hantavirus]], [[Ebola]], [[Lassa fever]] | ||
* Recent hospitalizations/ [[Vaccination|immunizations]] | * Recent hospitalizations/ [[Vaccination|immunizations]] | ||
* Any previous illnesses and recent [[Infection|infections]], [[Cancer|malignancies]] (eg, [[myelodysplastic syndrome]], [[leukemia]], [[lymphoma]], [[aplastic anemia]]) | * Any previous illnesses (esp. [[Hematologic diseases|hematologic]] and [[Rheumatologic disease|rheumatologic]]) and recent [[Infection|infections]], [[Cancer|malignancies]] (eg, [[myelodysplastic syndrome]], [[leukemia]], [[lymphoma]], [[aplastic anemia]]) | ||
* [[Pregnancy]] | * [[Pregnancy]] | ||
* [[Blood transfusion|Transfusions]] | * [[Blood transfusion|Transfusions]] | ||
* [[Organ transplant]] | * [[Organ transplant]] | ||
* Medications/ [[Herb|herbs]]/ chemicals/ [[Radiation (medicine)|radiation]] | * Medications ([[aspirin]], [[Non-steroidal anti-inflammatory drug|NSAID]]<nowiki/>s, [[heparin]], [[Low molecular weight heparin|LMWH]], etc.)/ [[Herb|herbs]]/ chemicals/ [[Radiation (medicine)|radiation]] | ||
* Family history of bleeding disorders and/or [[thrombocytopenia]]. ('''Note:''' Negative family history does not rule out the possibility of genetic [[Etiology|etiologies]] because some individuals with familial platelet disorders remain undiagnosed well into adulthood.) | * Family history of bleeding disorders and/or [[thrombocytopenia]]. ('''Note:''' Negative family history does not rule out the possibility of genetic [[Etiology|etiologies]] because some individuals with familial platelet disorders remain undiagnosed well into adulthood.) | ||
* Dietary habits (eg, vegetarianism) | |||
* High-risk behaviors ([[Human Immunodeficiency Virus (HIV)|HIV]], [[hepatitis]]) | * High-risk behaviors ([[Human Immunodeficiency Virus (HIV)|HIV]], [[hepatitis]]) | ||
* Alcohol/ drug use | * Alcohol/ drug use | ||
Revision as of 18:37, 17 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Farbod Zahedi Tajrishi, M.D. [2]
Overview
History
A thorough history is essential to an effective evaluation of thrombocytopenia. While some of the conditions leading to thrombocytopenia can be immediately diagnosed, others may require specific or repeated questioning. In addition to a well-investigated present illness, a precise past medical history can help a great deal to identify the cause of thrombocytopenia. The history should include questions about:[1][2]
- Bleeding (eg, petechiae, ecchymoses, epistaxis, gingival bleeding, hematemesis, melena, menorrhagia)
- Other symptpms such as fever, rashes, pain (eg, in bone), headache, or vision changes
- Recent travel (dengue fever, malaria, rickettsial infections, tick bite, leptospirosis, meningococcemia, Hantavirus, Ebola, Lassa fever
- Recent hospitalizations/ immunizations
- Any previous illnesses (esp. hematologic and rheumatologic) and recent infections, malignancies (eg, myelodysplastic syndrome, leukemia, lymphoma, aplastic anemia)
- Pregnancy
- Transfusions
- Organ transplant
- Medications (aspirin, NSAIDs, heparin, LMWH, etc.)/ herbs/ chemicals/ radiation
- Family history of bleeding disorders and/or thrombocytopenia. (Note: Negative family history does not rule out the possibility of genetic etiologies because some individuals with familial platelet disorders remain undiagnosed well into adulthood.)
- Dietary habits (eg, vegetarianism)
- High-risk behaviors (HIV, hepatitis)
- Alcohol/ drug use
Symptoms
References
- ↑ Greenberg EM, Kaled ES (2013). "Thrombocytopenia". Crit Care Nurs Clin North Am. 25 (4): 427–34, v. doi:10.1016/j.ccell.2013.08.003. PMID 24267279.
- ↑ Patel U, Gandhi G, Friedman S, Niranjan S (2004). "Thrombocytopenia in malaria". J Natl Med Assoc. 96 (9): 1212–4. PMC 2568454. PMID 15481750.