Peripheral neuropathy causes: Difference between revisions
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==Overview== | ==Overview== | ||
[[Diabetes mellitus]] is the most common cause of peripheral neuropathy in developed countries. As a summary; aside from diabetes (see [[Diabetic neuropathy]]), the common causes of neuropathy are [[herpes zoster]] infection, HIV-AIDS, toxins, alcoholism, chronic trauma (such as repetitive motion disorders) or acute trauma (including surgery), various neurotoxins and [[autoimmune]] conditions such as [[celiac disease]], which can account for approximately 16% of small fiber neuropathy cases. Neuropathic pain is common in [[cancer]] as a direct result of the cancer on [[peripheral nerves]] (e.g., compression by a [[tumor]]), as a side effect of many[[chemotherapy]] drugs, and as a result of [[electrical injury]]. In many cases the neuropathy is idiopathic, meaning no cause is found. A form of spinal nerve entrapment called [[Posterior Rami Syndrome]] can led to neuropathic pain. Other common causes of peripheral neuropathy may include: [[Friedreich's ataxia]], [[Charcot-Marie-Tooth syndrome]], [[Chronic renal failure]], [[Porphyria]], [[Amyloidosis]], [[Liver failure]], [[Hypothyroidism]], [[Alcoholism]], [[Vincristine]], [[Phenytoin]], [[Procarbazine]], [[Isoniazid]], [[Altretamine]], [[Guillain-Barré syndrome]], [[Systemic lupus erythematosus]], [[Leprosy]], [[Sjögren's syndrome]], Vitamin deficiency states([[Vitamin B12|vitamin B<sub>12</sub>]], [[Vitamin A]], [[vitamin E]], [[Thiamin|thiamin)]], malignant disease and [[Radiation]]. | |||
==Causes== | ==Causes== | ||
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:*[[Charcot-Marie-Tooth syndrome]] | :*[[Charcot-Marie-Tooth syndrome]] | ||
*Metabolic / Endocrine: | *Metabolic / Endocrine: | ||
:*[[Chronic renal failure]] | :*[[Chronic renal failure]] | ||
:*[[Porphyria]] | :*[[Porphyria]] | ||
Revision as of 16:14, 20 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2] Saumya Easaw, M.B.B.S.[3]
Overview
Diabetes mellitus is the most common cause of peripheral neuropathy in developed countries. As a summary; aside from diabetes (see Diabetic neuropathy), the common causes of neuropathy are herpes zoster infection, HIV-AIDS, toxins, alcoholism, chronic trauma (such as repetitive motion disorders) or acute trauma (including surgery), various neurotoxins and autoimmune conditions such as celiac disease, which can account for approximately 16% of small fiber neuropathy cases. Neuropathic pain is common in cancer as a direct result of the cancer on peripheral nerves (e.g., compression by a tumor), as a side effect of manychemotherapy drugs, and as a result of electrical injury. In many cases the neuropathy is idiopathic, meaning no cause is found. A form of spinal nerve entrapment called Posterior Rami Syndrome can led to neuropathic pain. Other common causes of peripheral neuropathy may include: Friedreich's ataxia, Charcot-Marie-Tooth syndrome, Chronic renal failure, Porphyria, Amyloidosis, Liver failure, Hypothyroidism, Alcoholism, Vincristine, Phenytoin, Procarbazine, Isoniazid, Altretamine, Guillain-Barré syndrome, Systemic lupus erythematosus, Leprosy, Sjögren's syndrome, Vitamin deficiency states(vitamin B12, Vitamin A, vitamin E, thiamin), malignant disease and Radiation.
Causes
Diabetes mellitus is the most common cause of peripheral neuropathy in developed countries.[1]
As a summary; aside from diabetes (see Diabetic neuropathy), the common causes of neuropathy are herpes zoster infection, HIV-AIDS, toxins, alcoholism, chronic trauma (such as repetitive motion disorders) or acute trauma (including surgery), various neurotoxins and autoimmune conditions such as celiac disease, which can account for approximately 16% of small fiber neuropathy cases.[2] Neuropathic pain is common in cancer as a direct result of the cancer on peripheral nerves (e.g., compression by a tumor), as a side effect of manychemotherapy drugs, and as a result of electrical injury. In many cases the neuropathy is idiopathic, meaning no cause is found. A form of spinal nerve entrapment called Posterior Rami Syndrome can led to neuropathic pain.
Common Causes
Other common causes of peripheral neuropathy may include:[3][4][5][6][7][8][9][10][11][12][13]
- Genetic diseases:
- Metabolic / Endocrine:
- Toxic causes:
- Alcoholism
- drugs
- Organic metals
- Inflammatory diseases:
- Vitamin deficiency states:
- Others:
- Malignant disease
- Radiation
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Misra UK, Kalita J, Nair PP (2008). "Diagnostic approach to peripheral neuropathy". Ann Indian Acad Neurol. 11 (2): 89–97. doi:10.4103/0972-2327.41875. PMC 2771953. PMID 19893645.
- ↑ "Up to 16% of Patients with Small Fiber Neuropathy May Have Celiac Disease". Celiac.com. Retrieved 2007-26-06. Check date values in:
|accessdate=(help) - ↑ Marchettini P, Lacerenza M, Mauri E, Marangoni C (2006). "Painful peripheral neuropathies". Curr Neuropharmacol. 4 (3): 175–81. PMC 2430688. PMID 18615140.
- ↑ Watson JC, Dyck PJ (2015). "Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management". Mayo Clin Proc. 90 (7): 940–51. doi:10.1016/j.mayocp.2015.05.004. PMID 26141332.
- ↑ Hughes RA (2002). "Peripheral neuropathy". BMJ. 324 (7335): 466–9. PMC 1122393. PMID 11859051.
- ↑ Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D; et al. (2017). "Neuropathic pain". Nat Rev Dis Primers. 3: 17002. doi:10.1038/nrdp.2017.2. PMC 5371025. PMID 28205574.
- ↑ Juster-Switlyk K, Smith AG (2016). "Updates in diabetic peripheral neuropathy". F1000Res. 5. doi:10.12688/f1000research.7898.1. PMC 4847561. PMID 27158461.
- ↑ Bansal V, Kalita J, Misra UK (2006). "Diabetic neuropathy". Postgrad Med J. 82 (964): 95–100. doi:10.1136/pgmj.2005.036137. PMC 2596705. PMID 16461471.
- ↑ Hanewinckel R, Ikram MA, Van Doorn PA (2016). "Peripheral neuropathies". Handb Clin Neurol. 138: 263–82. doi:10.1016/B978-0-12-802973-2.00015-X. PMID 27637963.
- ↑ Argov Z, Mastaglia FL (1979). "Drug-induced peripheral neuropathies". Br Med J. 1 (6164): 663–6. PMC 1598252. PMID 219931.
- ↑ Remiche G, Kadhim H, Maris C, Mavroudakis N (2013). "[Peripheral neuropathies, from diagnosis to treatment, review of the literature and lessons from the local experience]". Rev Med Brux. 34 (4): 211–20. PMID 24195230.
- ↑ Phan T, McLeod JG, Pollard JD, Peiris O, Rohan A, Halpern JP (1995). "Peripheral neuropathy associated with simvastatin". J Neurol Neurosurg Psychiatry. 58 (5): 625–8. PMC 1073498. PMID 7745415.
- ↑ Cohen JA, Gross KF (1990). "Peripheral neuropathy: causes and management in the elderly". Geriatrics. 45 (2): 21–6, 31–4. PMID 2153610.