Thrombocytosis differential diagnosis: Difference between revisions

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Revision as of 19:50, 22 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Thrombocytosis Differential Diagnosis

Differentiating the diseases that can cause thrombocytosis :

Category	Condition		Etiology	Mechanism			Inherited	Acquried	Clinical manifestations									Para−clinical findings									Gold standard	Associated findings
									Demography	History	Symptoms			Signs				Para−clinical findings
											Symptoms			Signs				Lab Findings								Imaging
											Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other	CBC			PBS	Bone marrow exam	PT	PTT	UA
				Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen					Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA
Autonomous thrombocytosis	Hematologic malignancies	Essential thrombocythemia
		Polycythemia vera
		Primary myelofibrosis
		Chronic myeloid leukemia
		Myelodysplastic syndromes^[1]	Unknown Mutation	+	-	-	-/+	+	Elderly	Exposure to Chemotherapy Radiation therapy Tobacco smoke	+	Petechiae, purpura, diffuse erythematous rash	+	Nl	+	+	Shortness of breath, fatigue	↓	↓	↓	Ovalomacrocytosis Basophilic stippling Howell-Jolly body Dysplastic neutrophils	Impaired myeloid maturation Dyserythropoiesis Dysgranulopoiesis Dysmegakaryocytopoiesis Hypercellular bone marrow Fibrosis	Nl	Nl	Nl	NA	Bone marrow examination + clinical manifestation	Might transformed to acute leukemia
		Acute myeloid leukemia
	Familial thrombocytosis
Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings
Reactive thrombocytosis	Anemia/ blood loss	Iron deficiency, blood loss, hemolysis
	Infection	Viral, bacterial, mycobacterial, and fungal causes
	Non-infectious inflammation	Malignancy, rheumatologic conditions, trauma, reactions to medications
	Post-splenectomy	Post-splenectomy or functional asplenia (eg, sickle cell disease)

Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings

References

↑ Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.

[NatelsonPyatt2013-1] Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.

[1]

@@ Line 50: / Line 50: @@
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
 |-
-! rowspan="7" |Autonomous '''thrombocytosis'''
+! rowspan="7" align="center" style="background:#DCDCDC;" |Autonomous thrombocytosis
-! rowspan="6" |'''Hematologic malignancies'''
+! rowspan="6" align="center" style="background:#DCDCDC;" |Hematologic malignancies
-!'''Essential thrombocythemia'''
+! align="center" style="background:#DCDCDC;" |Essential thrombocythemia
 !
 !
@@ Line 80: / Line 80: @@
 !
 |-
-!'''Polycythemia vera'''
+! align="center" style="background:#DCDCDC;" |Polycythemia vera
 !
 !
@@ Line 108: / Line 108: @@
 !
 |-
-!'''Primary myelofibrosis'''
+! align="center" style="background:#DCDCDC;" |Primary myelofibrosis
 !
 !
@@ Line 136: / Line 136: @@
 !
 |-
-!'''Chronic myeloid leukemia'''
+! align="center" style="background:#DCDCDC;" |Chronic myeloid leukemia
 !
 !
@@ Line 208: / Line 208: @@
 * Might transformed to [[acute leukemia]]
 |-
-! align="center" style="background:#DCDCDC;" + |'''Acute myeloid leukemia'''
+! align="center" style="background:#DCDCDC;" + |Acute myeloid leukemia
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
 | align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
@@ Line 236: / Line 236: @@
 | align="center" style="background:#F5F5F5;" + |
 |-
-! colspan="2" |'''Familial thrombocytosis'''
+! colspan="2" align="center" style="background:#DCDCDC;" |Familial thrombocytosis
 !
 !
@@ Line 293: / Line 293: @@
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
 |-
-! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Reactive thrombocytosis'''
+! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive thrombocytosis
 ! align="center" style="background:#DCDCDC;" + |Anemia/
 blood loss
 |Iron deficiency, blood loss, hemolysis
 | align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
@@ Line 325: / Line 324: @@
 | align="center" style="background:#F5F5F5;" + |
 |-
-!Infection
+! align="center" style="background:#DCDCDC;" |Infection
-!Viral, bacterial, mycobacterial, and fungal causes
+! align="center" style="background:#DCDCDC;" |Viral, bacterial, mycobacterial, and fungal causes
 !
 !
@@ Line 354: / Line 353: @@
 !
 |-
-!Non-infectious inflammation
+! align="center" style="background:#DCDCDC;" |Non-infectious inflammation
-!Malignancy, rheumatologic conditions, trauma, reactions to medications
+! align="center" style="background:#DCDCDC;" |Malignancy, rheumatologic conditions, trauma, reactions to medications
 !
 !
@@ Line 383: / Line 382: @@
 !
 |-
-!Post-splenectomy
+! align="center" style="background:#DCDCDC;" |Post-splenectomy
-!Post-splenectomy or functional asplenia (eg, sickle cell disease)
+! align="center" style="background:#DCDCDC;" |Post-splenectomy or functional asplenia (eg, sickle cell disease)
 !
 !

Thrombocytosis differential diagnosis: Difference between revisions

Revision as of 19:50, 22 August 2018

Overview

Thrombocytosis Differential Diagnosis

References

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