Thrombocytosis differential diagnosis: Difference between revisions

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Revision as of 20:39, 22 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Thrombocytosis Differential Diagnosis

Differentiating the diseases that can cause thrombocytosis :

Category	Condition		Etiology	Mechanism			Inherited	Acquried	Clinical manifestations									Para−clinical findings									Gold standard	Associated findings
									Demography	History	Symptoms			Signs				Para−clinical findings
											Symptoms			Signs				Lab Findings								Imaging
											Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other	CBC			PBS	Bone marrow exam	PT	PTT	UA
				Increased megakaryocyte proliferation	Accelerated platelet release	Reduced platelet turnover					Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA
Autonomous thrombocytosis	Hematologic malignancies	Essential thrombocythemia
		Polycythemia vera
		Primary myelofibrosis
		Chronic myeloid leukemia
		Myelodysplastic syndromes^[1]	Unknown Mutation	+	-	-	-/+	+	Elderly	Exposure to Chemotherapy Radiation therapy Tobacco smoke	+	Petechiae, purpura, diffuse erythematous rash	+	Nl	+	+	Shortness of breath, fatigue	↓	↓	↓	Ovalomacrocytosis Basophilic stippling Howell-Jolly body Dysplastic neutrophils	Impaired myeloid maturation Dyserythropoiesis Dysgranulopoiesis Dysmegakaryocytopoiesis Hypercellular bone marrow Fibrosis	Nl	Nl	Nl	NA	Bone marrow examination + clinical manifestation	Might transformed to acute leukemia
		Acute myeloid leukemia
	Familial thrombocytosis
Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings
Reactive thrombocytosis	Anemia/ blood loss	Iron deficiency Blood loss Hemolysis
	Malignancy	Metastatic cancer Lymphoma
	Infection	Chronic infections
		Tuberculosis
		Acute bacterial and viral infections
	Inflammation	Vasculitides
	Inflammation	Acute pancreatitis
	Tissue damage	Thermal burns
		Trauma
		Myocardial infarction
	Asplenia	Post-splenectomy or functional asplenia
	Medication	Myelosuppressive agents	Rebound effect
		Vincristine
		Epinephrine, glucocorticoids
		Interleukin-1B
		All-trans retinoic acid
		Thrombopoietin
	Other	Allergic reactions
	Other	Exercise
Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings

References

↑ Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.

[NatelsonPyatt2013-1] Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.

[1]

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 ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
 |-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Increased megakaryocyte proliferation
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in blood
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Accelerated platelet release
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in spleen
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reduced platelet turnover
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
 |-
-! rowspan="7" align="center" style="background:#4479BA;" |Autonomous thrombocytosis
+! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous thrombocytosis
 ! rowspan="6" align="center" style="background:#DCDCDC;" |Hematologic malignancies
 ! align="center" style="background:#DCDCDC;" |Essential thrombocythemia
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 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
 |-
-! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive thrombocytosis
+! rowspan="19" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive thrombocytosis
 ! align="center" style="background:#DCDCDC;" + |Anemia/
 blood loss
-! align="center" style="background:#DCDCDC;" |Iron deficiency, blood loss, hemolysis
+! align="center" style="background:#DCDCDC;" |
+* Iron deficiency
+* Blood loss
+* Hemolysis
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 |-
-! align="center" style="background:#DCDCDC;" |Infection
+!Malignancy
-! align="center" style="background:#DCDCDC;" |Viral, bacterial, mycobacterial, and fungal causes
+!
+* Metastatic cancer
+* Lymphoma
+!
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+! rowspan="3" align="center" style="background:#DCDCDC;" |Infection
+! align="center" style="background:#DCDCDC;" |Chronic infections
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 |-
-! align="center" style="background:#DCDCDC;" |Non-infectious inflammation
+!Tuberculosis
-! align="center" style="background:#DCDCDC;" |Malignancy, rheumatologic conditions, trauma, reactions to medications
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+!Acute bacterial and viral infections
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+! rowspan="2" align="center" style="background:#DCDCDC;" |Inflammation
+! align="center" style="background:#DCDCDC;" |Vasculitides
 | align="center" style="background:#F5F5F5;" + |
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 | align="center" style="background:#F5F5F5;" + |
 |-
-! align="center" style="background:#DCDCDC;" |Post-splenectomy
+!Acute pancreatitis
-! align="center" style="background:#DCDCDC;" |Post-splenectomy or functional asplenia (eg, sickle cell disease)
+!
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+|-
+! rowspan="3" |Tissue damage
+!Thermal burns
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+!Trauma
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+!Myocardial infarction
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+|-
+! align="center" style="background:#DCDCDC;" |Asplenia
+! align="center" style="background:#DCDCDC;" |Post-splenectomy or functional asplenia
 | align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
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 | align="center" style="background:#F5F5F5;" + |
 |-
+! rowspan="6" |Medication
+!Myelosuppressive agents
+!Rebound effect
+!
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+!Vincristine
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 !
 !
 !
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+!Epinephrine, glucocorticoids
+!
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+!Interleukin-1B
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+!All-trans retinoic acid
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+!Thrombopoietin
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+|-
+! rowspan="2" |'''Other'''
+!'''Allergic reactions'''
+!
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+!
+|-
+!'''Exercise'''
 !
 !

Thrombocytosis differential diagnosis: Difference between revisions

Revision as of 20:39, 22 August 2018

Overview

Thrombocytosis Differential Diagnosis

References

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