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! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous thrombocytosis
! rowspan="7" align="center" style="background:#DCDCDC;" |Autonomous thrombocytosis
! rowspan="6" align="center" style="background:#DCDCDC;" |Hematologic malignancies
! rowspan="6" align="center" style="background:#DCDCDC;" |Hematologic malignancies
! align="center" style="background:#DCDCDC;" |Essential thrombocythemia
! align="center" style="background:#DCDCDC;" |Essential thrombocythemia
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! align="center" style="background:#DCDCDC;" + |[[Myelodysplastic syndrome|Myelodysplastic syndromes]]<ref name="NatelsonPyatt2013">{{cite journal|last1=Natelson|first1=Ethan A.|last2=Pyatt|first2=David|title=Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog|journal=Advances in Hematology|volume=2013|year=2013|pages=1–11|issn=1687-9104|doi=10.1155/2013/309637}}</ref>
! align="center" style="background:#DCDCDC;" + |[[Myelodysplastic syndrome|Myelodysplastic syndromes]]<ref name="NatelsonPyatt2013">{{cite journal|last1=Natelson|first1=Ethan A.|last2=Pyatt|first2=David|title=Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog|journal=Advances in Hematology|volume=2013|year=2013|pages=1–11|issn=1687-9104|doi=10.1155/2013/309637}}</ref>
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! colspan="2" align="center" style="background:#DCDCDC;" |Familial thrombocytosis
! colspan="2" align="center" style="background:#DCDCDC;" |Familial thrombocytosis
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! align="center" style="background:#DCDCDC;" |Infection  
! align="center" style="background:#DCDCDC;" |Infection  
! align="center" style="background:#DCDCDC;" |Viral, bacterial, mycobacterial, and fungal causes
! align="center" style="background:#DCDCDC;" |Viral, bacterial, mycobacterial, and fungal causes
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! align="center" style="background:#DCDCDC;" |Non-infectious inflammation
! align="center" style="background:#DCDCDC;" |Non-infectious inflammation
! align="center" style="background:#DCDCDC;" |Malignancy, rheumatologic conditions, trauma, reactions to medications
! align="center" style="background:#DCDCDC;" |Malignancy, rheumatologic conditions, trauma, reactions to medications
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! align="center" style="background:#DCDCDC;" |Post-splenectomy or functional asplenia (eg, sickle cell disease)
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Revision as of 19:52, 22 August 2018

Thrombocytosis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Thrombocytosis Differential Diagnosis

Differentiating the diseases that can cause thrombocytosis :

Category Condition Etiology Mechanism Inherited Acquried Clinical manifestations Para−clinical findings Gold standard Associated findings
Demography History Symptoms Signs
Lab Findings Imaging
Fever Rash Bleeding BP Splenomegaly Jaundice Other CBC PBS Bone marrow exam PT PTT UA
Decreased platelet production Platelet destruction in blood Platelet destruction in spleen Plt HB WBC
Autonomous thrombocytosis Hematologic malignancies Essential thrombocythemia
Polycythemia vera
Primary myelofibrosis
Chronic myeloid leukemia
Myelodysplastic syndromes[1]
  • Unknown
  • Mutation
 + - - -/+ + Elderly Exposure to + Petechiae, purpura, diffuse erythematous rash + Nl + + Shortness of breath, fatigue ↓ ↓ ↓ Nl Nl Nl NA Bone marrow examination + clinical manifestation
Acute myeloid leukemia
Familial thrombocytosis
Category Condition Etiology Decreased platelet production Platelet destruction in blood Platelet destruction in spleen Inherited Acquried Demography History Fever Rash Bleeding BP Splenomegaly Jaundice Other signs Plt HB WBC PBS Bone marrow exam PT PTT UA Imaging Gold standard Associated findings
Reactive thrombocytosis Anemia/

blood loss

Iron deficiency, blood loss, hemolysis
Infection Viral, bacterial, mycobacterial, and fungal causes
Non-infectious inflammation Malignancy, rheumatologic conditions, trauma, reactions to medications
Post-splenectomy Post-splenectomy or functional asplenia (eg, sickle cell disease)
Category Condition Etiology Decreased platelet production Platelet destruction in blood Platelet destruction in spleen Inherited Acquried Demography History Fever Rash Bleeding BP Splenomegaly Jaundice Other signs Plt HB WBC PBS Bone marrow exam PT PTT UA Imaging Gold standard Associated findings

References

  1. ↑ Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.
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