Thrombocytosis differential diagnosis: Difference between revisions
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! rowspan=" | ! rowspan="20" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive thrombocytosis | ||
! align="center" style="background:#DCDCDC;" + |Anemia/ | ! align="center" style="background:#DCDCDC;" + |Anemia/ | ||
blood loss | blood loss | ||
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! colspan="2" |Condition | |||
!Etiology | |||
!Decreased platelet production | |||
!Platelet destruction in blood | |||
!Platelet destruction in spleen | |||
!Inherited | |||
!Acquried | |||
!Demography | |||
!History | |||
!Fever | |||
!Rash | |||
!Bleeding | |||
!BP | |||
!Splenomegaly | |||
!Jaundice | |||
!Other signs | |||
!Plt | |||
!HB | |||
!WBC | |||
!PBS | |||
!Bone marrow exam | |||
!PT | |||
!PTT | |||
!UA | |||
!Imaging | |||
!Gold standard | |||
!Associated findings | |||
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! rowspan="3" align="center" style="background:#DCDCDC;" + |Tissue damage | ! rowspan="3" align="center" style="background:#DCDCDC;" + |Tissue damage | ||
Revision as of 14:29, 28 August 2018
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Thrombocytosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Thrombocytosis differential diagnosis On the Web |
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American Roentgen Ray Society Images of Thrombocytosis differential diagnosis |
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Risk calculators and risk factors for Thrombocytosis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Thrombocytosis Differential Diagnosis
Differentiating the diseases that can cause thrombocytosis :
| Category | Condition | Etiology | Mechanism | Inherited | Acquried | Clinical manifestations | Para−clinical findings | Gold standard | Associated findings | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Demography | History | Symptoms | Signs | |||||||||||||||||||||||||
| Lab Findings | Imaging | |||||||||||||||||||||||||||
| Fever | Rash | Bleeding | BP | Splenomegaly | Jaundice | Other | CBC | PBS | Bone marrow exam | PT | PTT | UA | ||||||||||||||||
| Increased megakaryocyte proliferation | Accelerated platelet release | Reduced platelet turnover | Plt | HB | WBC | |||||||||||||||||||||||
| Autonomous thrombocytosis | Hematologic malignancies | Essential thrombocythemia | ||||||||||||||||||||||||||
| Polycythemia vera | ||||||||||||||||||||||||||||
| Primary myelofibrosis | ||||||||||||||||||||||||||||
| Chronic myeloid leukemia | ||||||||||||||||||||||||||||
| Myelodysplastic syndromes[1] |
|
+ | - | - | -/+ | + | Elderly | Exposure to | + | Petechiae, purpura, diffuse erythematous rash | + | Nl | + | + | Shortness of breath, fatigue | ↓ | ↓ | ↓ |
|
|
Nl | Nl | Nl | NA | Bone marrow examination + clinical manifestation |
| ||
| Acute myeloid leukemia | ||||||||||||||||||||||||||||
| Familial thrombocytosis | ||||||||||||||||||||||||||||
| Category | Condition | Etiology | Decreased platelet production | Platelet destruction in blood | Platelet destruction in spleen | Inherited | Acquried | Demography | History | Fever | Rash | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Imaging | Gold standard | Associated findings | |
| Reactive thrombocytosis | Anemia/
blood loss |
|
||||||||||||||||||||||||||
| Infection | Chronic infections | |||||||||||||||||||||||||||
| Tuberculosis | ||||||||||||||||||||||||||||
| Acute bacterial and viral infections | ||||||||||||||||||||||||||||
| Inflammation | Vasculitides | |||||||||||||||||||||||||||
| Acute pancreatitis | ||||||||||||||||||||||||||||
| Malignancy | ||||||||||||||||||||||||||||
| Condition | Etiology | Decreased platelet production | Platelet destruction in blood | Platelet destruction in spleen | Inherited | Acquried | Demography | History | Fever | Rash | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Imaging | Gold standard | Associated findings | ||
| Tissue damage | Thermal burns | |||||||||||||||||||||||||||
| Trauma | ||||||||||||||||||||||||||||
| Myocardial infarction | ||||||||||||||||||||||||||||
| Medication | Myelosuppressive agents | |||||||||||||||||||||||||||
| Vincristine | ||||||||||||||||||||||||||||
| Epinephrine, glucocorticoids | ||||||||||||||||||||||||||||
| Interleukin-1B | ||||||||||||||||||||||||||||
| All-trans retinoic acid | ||||||||||||||||||||||||||||
| Thrombopoietin | ||||||||||||||||||||||||||||
| Other | Post-splenectomy or functional asplenia | |||||||||||||||||||||||||||
| Allergic reactions | ||||||||||||||||||||||||||||
| Exercise | ||||||||||||||||||||||||||||
| Category | Condition | Etiology | Decreased platelet production | Platelet destruction in blood | Platelet destruction in spleen | Inherited | Acquried | Demography | History | Fever | Rash | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Imaging | Gold standard | Associated findings | |
References
- ↑ Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.