Multiple myeloma causes: Difference between revisions
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{{Multiple myeloma}} | {{Multiple myeloma}} | ||
{{CMG}} {{AE}}{{HL}} {{shyam}} | |||
==Overview== | ==Overview== | ||
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===Common causes=== | ===Common causes=== | ||
The causes of multiple myeloma include: | The causes of multiple myeloma include: | ||
*Sporadic mutations and genetic predisposition | *Sporadic mutations and genetic predisposition | ||
*Mutations in tumor suppressors or oncogenes | *Mutations in tumor suppressors or oncogenes | ||
*Mutations in the tumor suppressor ''TP53'' | *Mutations in the tumor suppressor ''TP53'' (most common) | ||
*Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.<ref name="pmid27291302">{{cite journal| author=Rajkumar SV| title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. | journal=Am J Hematol | year= 2016 | volume= 91 | issue= 7 | pages= 719-34 | pmid=27291302 | doi=10.1002/ajh.24402 | pmc=5291298 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27291302 }} </ref> | *Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.<ref name="pmid27291302">{{cite journal| author=Rajkumar SV| title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. | journal=Am J Hematol | year= 2016 | volume= 91 | issue= 7 | pages= 719-34 | pmid=27291302 | doi=10.1002/ajh.24402 | pmc=5291298 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27291302 }} </ref> | ||
===Less common causes=== | ===Less common causes=== | ||
* Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.<ref name="pmid27291302">{{cite journal| author=Rajkumar SV| title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. | journal=Am J Hematol | year= 2016 | volume= 91 | issue= 7 | pages= 719-34 | pmid=27291302 | doi=10.1002/ajh.24402 | pmc=5291298 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27291302 }} </ref> | * Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.<ref name="pmid27291302">{{cite journal| author=Rajkumar SV| title=Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management. | journal=Am J Hematol | year= 2016 | volume= 91 | issue= 7 | pages= 719-34 | pmid=27291302 | doi=10.1002/ajh.24402 | pmc=5291298 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27291302 }} </ref> | ||
==References== | |||
== References == | {{Reflist|2}} | ||
{{ | [[Category:Medicine]] | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Neurosurgery]] | [[Category:Neurosurgery]] | ||
[[Category:Oncology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Primary care]] | |||
[[Category:Surgery]] | |||
Revision as of 17:04, 3 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]
Overview
The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.
Causes
Common causes
The causes of multiple myeloma include:
- Sporadic mutations and genetic predisposition
- Mutations in tumor suppressors or oncogenes
- Mutations in the tumor suppressor TP53 (most common)
- Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.[1]
Less common causes
- Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.[1]
References
- ↑ 1.0 1.1 Rajkumar SV (2016). "Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management". Am J Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.