Bleeding diathesis

Bleeding diathesis main page
Overview
Classification
Differential Diagnosis Platelet disorders Immune Thrombocytopenic Purpura Thrombotic Thrombocytopenic Purpura Hemolytic Uremic Syndrome Thrombocytosis Von Willebrand Disease
Coagulation disorders Fibrinogen deficiency Prothrombin deficiency Factor V deficiency Factor VII deficiency Factor VIII deficiency Factor IX deficiency Factor X deficiency Factor XI deficiency Factor XII deficiency High-molecular-weight kininogen deficiency Prekallikrein deficiency Factor XIII deficiency Hemophilia
Rare diseases Disseminated Intravascular Coagulation Vitamin K Deficiency
Different types of Von-Willebrand diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Mehrian Jafarizade, M.D [2]

Differential Diagnosis

Disorders of the Coagulation Cascade

1. Inherited Bleeding Disorders Examples: Hemophilia A (Factor VIII deficiency), Hemophilia B (Factor IX deficiency), Von Willebrand disease and congenital fibrinogen deficiency. Studies from the Kingdom have shown that the distribution of hereditary bleeding disorders (HBD) resemble what has been established in western countries, with the exception of an increase of platelet disorders mostly due to the increased rate of consanguinity in the Kingdom.27–29 The most common HBD in the Kingdom is hemophilia A, followed by VWD, then hemophilia B followed by qualitative platelet disorders most commonly Glanzmanns thrombasthenia.27–29
2. Acquired Bleeding Disorders These include liver disease, vitamin K deficiency, DIC and anticoagulant therapy.3

Category	Sub-category	Diseases	History	Clinical manifestation					Laboratory testing
				Petechiae	Ecchymoses	Menorrhagia	Hematomas	Hemarthrosis	platelet count	Bleeding time (BT)	Prothrombin time (PT)	Platelet count activated partial thromboplastin time (aPTT)	Thrombin time (TT)
Platelet disorders	Thrombocytopenia	Infection-Induced Thrombocytopenia
		Medications-Induced Thrombocytopenia
		Heparin-Induced Thrombocytopenia
		Immune Thrombocytopenic Purpura (ITP)
		Inherited Thrombocytopenia
		Thrombotic Thrombocytopenic Purpura (TTP)
		Hemolytic Uremic Syndrome
	Thromobcytosis	Thrombocytosis in response to acute or chronic inflammation has not been associated with an increased thrombotic risk. In fact, patients with markedly elevated platelet counts (>1.5 million), usually seen in the setting of a myeloproliferative disorder, have an increased risk of bleeding. This appears to be due, at least in part, to acquired von Willebrand disease (VWD) due to platelet-VWF adhesion and removal.
	Qualitative Disorders of Platelet Function	Inherited Disorders of Platelet Function
		Acquired Disorders of Platelet Function
		Von Willebrand Disease
Vessel wall disorders	Metabolic and Inflammatory Disorders
	Inherited Disorders of the Vessel Wall
Coagulation disorders	Fibrinogen deficiency
	Prothrombin deficiency
	Factor V deficiency
	Factor VII deficiency
	Factor VIII deficiency
	Factor IX deficiency
	Factor X deficiency
	Factor XI deficiency
	Factor XII deficiency
	HK deficiency
	Prekallikrein deficiency
	Factor XIII deficiency
	Hemophilia	Type A deficiency							Unaffected	Unaffected	Unaffected	Prolonged
		Type B deficiency
		Type C deficiency
Rare diseases	Disseminated Intravascular Coagulation
	Vitamin K Deficiency
	Coagulation Disorders Associated with Liver Failure
	Acquired Inhibitors of Coagulation Factors