Thrombotic thrombocytopenic purpura laboratory findings

Thrombotic thrombocytopenic purpura Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Thrombotic thrombocytopenic purpura from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Peripheral Smear
Direct Coombs Test
von Willebrand Factor-cleaving Protease Activity
X-ray
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Thrombotic thrombocytopenic purpura laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Thrombotic thrombocytopenic purpura laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Thrombotic thrombocytopenic purpura laboratory findings
CDC on Thrombotic thrombocytopenic purpura laboratory findings
Thrombotic thrombocytopenic purpura laboratory findings in the news
Blogs on Thrombotic thrombocytopenic purpura laboratory findings
Directions to Hospitals Treating Thrombotic thrombocytopenic purpura
Risk calculators and risk factors for Thrombotic thrombocytopenic purpura laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2] lease help WikiDoc by adding content here. It's easy! Click here to learn about editing.

Laboratory Findings

• CBC shows:
  • Thrombocytopenia (median platelet count 10,000/microL)
  • Microangiopathic hemolytic anemia :

Hemolytic anemia
LDH ↑ Indirect bilirubin ↑ Serum haptoglubin ↓ Retic count ↑ Combs tests negative Hb ~7 g/dl, Hct ~21%

• Peripheral blood smear: Schistocytes, including helmet cells and triangular cells, polychromasia, microspherocytes and nucleated RBCs
• Urinalysis: Hematuria, proteinuria
• Serum creatinine: Increased
• Urine output: Decreased
• ADAMTS13 test: ADAMTS13 activity or inhibitor provides information for the diagnosis of the types and causes of TTP:
  • ADAMTS13 activity: Decreased to < 10% during acute episodes of TTP.
  • ADAMTS13 inhinbitors test:
• Genetic testing: Should be done in suspected cases of,
  • Positive family history
  • Recurrent episodes
  • Onset during childhood or pregnancy
  • Absence of inhibitors
  • Persistent ADAMTS13 deficiency
• Imaging: In cases with higher suspicion of TTP, imaging is not necessary but with focal neurological signs MRI or CT may be considered
• Blood culture: Patients with fever or signs and symptoms of infections
• Stool exam: Stool culture and toxin evaluation should be considered in patients with diarrhea as one of the main presentation especially bloody diarrhea
• Pathology: Tissue biopsy is not necessary for diagnosis, but it may show classic changes of a thrombotic microangiopathy including platelet microthrombi in small arterioles or capillaries, or hyaline changes in and around vessel walls.