Sandbox: wdx causes: Difference between revisions

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{|
{|
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! rowspan="5" |Disease
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
sequestration/
sequestration/
redistribution
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
|-
|-
! rowspan="9" |Hematologic disorders
! rowspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic disorders
!Myelodysplastic syndromes (MDS)
! align="center" style="background:#DCDCDC;" |Myelodysplastic syndromes (MDS)
|
|
* Bone marrow infiltration
* Bone marrow infiltration
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!
!
|-
|-
!Malignancies such as:
! align="left" style="background:#DCDCDC;" |Malignancies such as:
* Acute leukemias
* Acute leukemias
* Chronic leukemias
* Chronic leukemias
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| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!Myelofibrosis
! align="center" style="background:#DCDCDC;" |Myelofibrosis
| align="center" style="background:#F5F5F5;" + |Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + |Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
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| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
!Fanconi anemia
! align="center" style="background:#DCDCDC;" |Fanconi anemia
!
!
!
!
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!
!
|-
|-
!Aplastic anemia
! align="center" style="background:#DCDCDC;" |Aplastic anemia
!Immune destruction
!Immune destruction
!
!
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!
!
|-
|-
!Paroxysmal nocturnal hemoglobinuria
! align="center" style="background:#DCDCDC;" |Paroxysmal nocturnal hemoglobinuria
!Immune destruction
!Immune destruction
!
!
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!
!
|-
|-
!Disseminated intravascular coagulation
! align="center" style="background:#DCDCDC;" |Disseminated intravascular coagulation
!Consumption
!Consumption
!
!
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!
!
|-
|-
!Dyskeratosis congenital/telomere biology disorders
! align="center" style="background:#DCDCDC;" |Dyskeratosis congenital/telomere biology disorders
!
!
!
!
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!
!
|-
|-
!Shwachman-Diamond syndrome
! align="center" style="background:#DCDCDC;" |Shwachman-Diamond syndrome
!
!
!
!
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!
!
|-
|-
! rowspan="5" |Immunology/
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/
Rheumatology
Rheumatology
!SLE
! align="center" style="background:#DCDCDC;" |SLE
!
!
!
!
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!
!
|-
|-
!Felty syndrome
! align="center" style="background:#DCDCDC;" |Felty syndrome
!
!
!
!
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!
!
|-
|-
!Wiskott Aldrich syndrome
! align="center" style="background:#DCDCDC;" |Wiskott Aldrich syndrome
!
!
!
!
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!
!
|-
|-
!GATA2 deficiency
! align="center" style="background:#DCDCDC;" |GATA2 deficiency
!
!
!
!
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!
!
|-
|-
!Hemophagocytic lymphohistiocytosis (HLH)
! align="center" style="background:#DCDCDC;" |Hemophagocytic lymphohistiocytosis (HLH)
!
!
!
!
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!
!
|-
|-
! rowspan="2" |GI disorders
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |GI disorders
!Portal hypertension/cirrhosis
! align="center" style="background:#DCDCDC;" |Portal hypertension/cirrhosis
!Splenomegaly
!Splenomegaly
!
!
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!
!
|-
|-
!Storage diseases (eg, Gaucher)
! align="center" style="background:#DCDCDC;" |Storage diseases (eg, Gaucher)
!
!
* Splenomegaly
* Splenomegaly
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!
!
|-
|-
! rowspan="2" |Infections
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infections
!Sepsis
! align="center" style="background:#DCDCDC;" |Sepsis
!Bone marrow infiltration
!Bone marrow infiltration
!+
!+
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!
!
|-
|-
!Viral infection such as HIV, hepatitis, Epstein-Barr virus  
! align="center" style="background:#DCDCDC;" |Viral infection such as HIV, hepatitis, Epstein-Barr virus  
!
!
* Marrow suppression
* Marrow suppression
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!
!
|-
|-
! rowspan="4" |Nutritional
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nutritional
!Megaloblastic anemia
! align="center" style="background:#DCDCDC;" |Megaloblastic anemia
|Ineffective hematopoiesis
|Ineffective hematopoiesis
|
|
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!
!
|-
|-
!Excessive alcohol
! align="center" style="background:#DCDCDC;" |Excessive alcohol
|Ineffective hematopoiesis
|Ineffective hematopoiesis
!
!
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!
!
|-
|-
!Other (eg, copper deficiency, zinc toxicity)
! align="center" style="background:#DCDCDC;" |Other (eg, copper deficiency, zinc toxicity)
|Ineffective hematopoiesis
|Ineffective hematopoiesis
!
!
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!
!
|-
|-
!Malnutrition
! align="center" style="background:#DCDCDC;" |Malnutrition
|Ineffective hematopoiesis
|Ineffective hematopoiesis
!
!
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!
!
|-
|-
!Medications
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medications
!Medications such as:
! align="left" style="background:#DCDCDC;" |Medications such as:
* Cytotoxic drugs
* Cytotoxic drugs
* Idiosyncratic reactions to medications
* Idiosyncratic reactions to medications
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|}
|}
<references />

Revision as of 03:20, 28 August 2018

Differentiating Pancytopenia from Other Diseases

  • Pancytopenia must be differentiated from a pseudo-syndromes like pseudo-thrombocytopenia, which is a laboratory artifact from platelet clumping.
  • There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing (complete blood count).
Category Disease Etiology Mechanism Congenital Acquried Clinical manifestations Para−clinical findings Gold standard Associated findings
Demography History Symptoms Signs
Lab Findings Imaging
Fever Rash Bleeding BP Splenomegaly Jaundice Other CBC PBS Bone marrow exam PT PTT UA
Bone marrow infiltration Bone marrow failure Destruction/

sequestration/ redistribution

Plt HB WBC
Hematologic disorders Myelodysplastic syndromes (MDS)
  • Bone marrow infiltration
  • Ineffective hematopoiesis
Malignancies such as:
  • Acute leukemias
  • Chronic leukemias
  • Multiple myeloma
  • Metastatic cancer
  • Bone marrow infiltration
  • Ineffective hematopoiesis
 + + +
Myelofibrosis Bone marrow infiltration +
Fanconi anemia +
Aplastic anemia Immune destruction +
Paroxysmal nocturnal hemoglobinuria Immune destruction +
Disseminated intravascular coagulation Consumption +
Dyskeratosis congenital/telomere biology disorders +
Shwachman-Diamond syndrome +
Immunology/

Rheumatology

SLE
Felty syndrome
Wiskott Aldrich syndrome +
GATA2 deficiency +
Hemophagocytic lymphohistiocytosis (HLH) +
GI disorders Portal hypertension/cirrhosis Splenomegaly +
Storage diseases (eg, Gaucher)
  • Splenomegaly
  • Bone marrow infiltration
 + +
Infections Sepsis Bone marrow infiltration +
Viral infection such as HIV, hepatitis, Epstein-Barr virus
  • Marrow suppression
  • Splenomegaly
 + +
Nutritional Megaloblastic anemia Ineffective hematopoiesis +
Excessive alcohol Ineffective hematopoiesis
Other (eg, copper deficiency, zinc toxicity) Ineffective hematopoiesis
Malnutrition Ineffective hematopoiesis
Medications Medications such as:
  • Cytotoxic drugs
  • Idiosyncratic reactions to medications
 Immune destruction +
Category Etiology Decreased platelet production Platelet destruction in blood Platelet destruction in spleen Congenital Acquried Demography History Fever Rash Bleeding BP Splenomegaly Jaundice Other signs Plt HB WBC PBS Bone marrow exam PT PTT UA Imaging Gold standard Associated findings
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