Thrombocytosis differential diagnosis: Difference between revisions

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Revision as of 14:30, 28 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Thrombocytosis Differential Diagnosis

Differentiating the diseases that can cause thrombocytosis :

Category	Condition		Etiology	Mechanism			Inherited	Acquried	Clinical manifestations									Para−clinical findings									Gold standard	Associated findings
									Demography	History	Symptoms			Signs				Para−clinical findings
											Symptoms			Signs				Lab Findings								Imaging
											Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other	CBC			PBS	Bone marrow exam	PT	PTT	UA
				Increased megakaryocyte proliferation	Accelerated platelet release	Reduced platelet turnover					Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA
Autonomous thrombocytosis	Hematologic malignancies	Essential thrombocythemia
		Polycythemia vera
		Primary myelofibrosis
		Chronic myeloid leukemia
		Myelodysplastic syndromes^[1]	Unknown Mutation	+	-	-	-/+	+	Elderly	Exposure to Chemotherapy Radiation therapy Tobacco smoke	+	Petechiae, purpura, diffuse erythematous rash	+	Nl	+	+	Shortness of breath, fatigue	↓	↓	↓	Ovalomacrocytosis Basophilic stippling Howell-Jolly body Dysplastic neutrophils	Impaired myeloid maturation Dyserythropoiesis Dysgranulopoiesis Dysmegakaryocytopoiesis Hypercellular bone marrow Fibrosis	Nl	Nl	Nl	NA	Bone marrow examination + clinical manifestation	Might transformed to acute leukemia
		Acute myeloid leukemia
	Familial thrombocytosis
Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings
Reactive thrombocytosis	Anemia/ blood loss	Iron deficiency Blood loss Hemolysis
	Infection	Chronic infections
		Tuberculosis
		Acute bacterial and viral infections
	Inflammation	Vasculitides
		Acute pancreatitis
		Malignancy
	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings
	Tissue damage	Thermal burns
		Trauma
		Myocardial infarction
	Medication	Myelosuppressive agents
		Vincristine
		Epinephrine, glucocorticoids
		Interleukin-1B
		All-trans retinoic acid
		Thrombopoietin
	Other	Post-splenectomy or functional asplenia
		Allergic reactions
		Exercise
Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings

References

↑ Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.

[NatelsonPyatt2013-1] Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.

[1]

@@ Line 497: / Line 497: @@
 | align="center" style="background:#F5F5F5;" + |
 |-
-! colspan="2" |Condition
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
-!Etiology
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
-!Decreased platelet production
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production
-!Platelet destruction in blood
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in blood
-!Platelet destruction in spleen
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in spleen
-!Inherited
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inherited
-!Acquried
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
-!Demography
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
-!History
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
-!Fever
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
-!Rash
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
-!Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
-!BP
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
-!Splenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
-!Jaundice
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
-!Other signs
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
-!Plt
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
-!HB
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-!WBC
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
-!PBS
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
-!Bone marrow exam
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
-!PT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
-!PTT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
-!UA
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
-!Imaging
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
-!Gold standard
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
-!Associated findings
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
 |-
 ! rowspan="3" align="center" style="background:#DCDCDC;" + |Tissue damage

Thrombocytosis differential diagnosis: Difference between revisions

Revision as of 14:30, 28 August 2018

Overview

Thrombocytosis Differential Diagnosis

References

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