Spondyloarthropathy causes: Difference between revisions

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Here are some locus, gene, and function of definite and probable genetic risk factors for SpA.
Here are some locus, gene, and function of definite and probable genetic risk factors for SpA.
{| style="border: 3px; font-size; 190%; margin: 1px; width: 800px" align="center"
! colspan="7" style="background: #ff8c00; width: 800px:" | {{fontcolor|#FFF|Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA}}
|-
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|locus}}
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Gene}}
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Function}}
! colspan="3" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Association with}}
|-
! style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Ankylosing spondylitis}}
! style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Psoriasis}}
! style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Inflammatory bowel disease}}
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |6p21.3
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |HLA-B27
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Antigene presentation
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |5q15
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |ERAP1
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Aminopeptidase
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |1p31.2
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |IL23R
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Cytokine receptor
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |2p15
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |21q22
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |12p13.2
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |TNFRSF1A
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Cytokine receptor
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |16q22
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |TRADD
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Signaling
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |9q32
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |TNFSF15
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Inflammatory cytokine
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Yes
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |2q14
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |IL1A
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Inflammatory cytokine
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |2q12
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |IL1R2
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Cytokine receptor
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |9q34
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |CARD9
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Innate immune defence
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|-
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |4q21.1
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |ANTXR2
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Vascular morphogenesis
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |Probable
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
| style="padding: 5px 5px; background: #DCDCDC; " align="center" |..
|}}

Revision as of 21:41, 28 August 2018

causes

Albiet, all the progresses have been made through investigating the cause of spondyloarthropathies, the exact cause of this disease remained unclear, however, the role of genetic have been seen through numerous studies have been made in this field of study. Studies demonstrated the role of HLA-B27 in the occurrence of spondyloarthropathies.

Here are some locus, gene, and function of definite and probable genetic risk factors for SpA.

Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA
locus Gene Function Association with
Ankylosing spondylitis Psoriasis Inflammatory bowel disease
6p21.3 HLA-B27 Antigene presentation Yes .. ..
5q15 ERAP1 Aminopeptidase Yes Probable ..
1p31.2 IL23R Cytokine receptor Yes Yes Yes
2p15 .. .. Yes .. ..
21q22 .. .. Yes .. ..
12p13.2 TNFRSF1A Cytokine receptor Probable .. Yes
16q22 TRADD Signaling Probable .. ..
9q32 TNFSF15 Inflammatory cytokine Probable .. Yes
2q14 IL1A Inflammatory cytokine Probable .. ..
2q12 IL1R2 Cytokine receptor Probable .. ..
9q34 CARD9 Innate immune defence Probable .. ..
4q21.1 ANTXR2 Vascular morphogenesis Probable .. ..

}

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