Thymoma differential diagnosis: Difference between revisions
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{{CMG}} {{AE}} {{AM}} {{AAM}} [[User:K.Nouman|Khuram Nouman, M.D. [4]]] | {{CMG}} {{AE}} {{AM}} {{AAM}} [[User:K.Nouman|Khuram Nouman, M.D. [4]]] | ||
==Overview== | ==Overview== |
Revision as of 13:47, 10 October 2018
Thymoma Microchapters |
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Thymoma differential diagnosis On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2] Ahmad Al Maradni, M.D. [3] Khuram Nouman, M.D. [4]
Overview
Thymoma must be differentiated from other diseases such as thymic carcinoma, mediastinal germ cell tumor,thymic masses,lymphoma and substernal thyroid.
Differential Diagnosis
Thymoma must be differentiated from other diseases as:
Diseases | Site | Clinical Features | Pathology | Labs | ||||
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Mediastinal Part | Systemic Symptoms | Obstructive symptoms | Additional Features | Cell Organization | Tumor Cells | Lymphoid Cells | Additional Tests | |
Mediastinal Germ Cell Tumor | Anterior |
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Non-adhesive |
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Thymic masses(Thymoma Cyst,Thymic Carcinoma,Thymolipoma,parathyroid hyperplasia) | Anterior |
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Varies |
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Lymphoma(Non-Hodgkin Lymphoma & Hodgkin Lymphoma) | Anterior,middle |
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Non-adhesive |
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Substernal Goiter & Thyroid Lymphoma | Anterior |
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Varies |
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Thymomas Vs Thymic Carcinomas:
- The following table shows the important differences between thymomas and thymic carcinomas:
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Other differentials
Thymoma must be differentiated from other similar conditions which lead to multiple endocrine disorders such as autoimmune polyendocrine syndrome, POEMS syndrome, Hirata syndrome, Kearns–Sayre syndrome and Wolfram syndromes.
Disease | Addison's disease | Type 1 diabetes mellitus | Hypothyroidism | Other disorders present |
---|---|---|---|---|
APS type 1 | + | Less common | Less common | Hypoparathyroidism Candidiasis Hypogonadism |
APS type 2 | + | + | + | Hypogonadism Malabsorption |
APS type 3 | - | + | + | Malabsorption |
Thymoma | + | - | + | Myasthenia gravis Cushing syndrome |
Chromosomal abnormalities (Turner syndrome, Down's syndrome) |
- | + | + | Cardiac dysfunction |
Kearns–Sayre syndrome | - | + | - | Myopathy Hypoparathyroidism Hypogonadism |
Wolfram syndrome | - | + | - | Diabetes insipidus Optic atrophy Deafness |
POEMS syndrome | - | + | - | Polyneuropathy Hypogonadism Plasma cell dyscrasias |