Thrombotic thrombocytopenic purpura differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
== Differential Diagnosis == | == Differential Diagnosis == | ||
The main differential diagnosis of TTP is [[hemolytic-uremic syndrome]] (HUS | The main differential diagnosis of TTP is [[hemolytic-uremic syndrome]] (HUS: which has neurosymptoms, renal failure, hypertension and fever). Note that ADAMTS13 activity is normal in HUS.<ref name="JolyCoppo2017">{{cite journal|last1=Joly|first1=Bérangère S.|last2=Coppo|first2=Paul|last3=Veyradier|first3=Agnès|title=Thrombotic thrombocytopenic purpura|journal=Blood|volume=129|issue=21|year=2017|pages=2836–2846|issn=0006-4971|doi=10.1182/blood-2016-10-709857}}</ref> | ||
TTP must be differentiated from | TTP must be differentiated from | ||
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* Ischemic manifestations linked to autoimmune diseases | * Ischemic manifestations linked to autoimmune diseases | ||
===Differentiating | ===Differentiating TTP from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]=== | ||
On the basis [symptom 1], [symptom 2], and [symptom 3], | On the basis [symptom 1], [symptom 2], and [symptom 3],TTP must be differentiated from | ||
Autoimmune haemolysis | |||
Evans syndrome Disseminated intravascular coagulation Pregnancy-associated such as: HELLP (haemolysis, elevated liver enzymes and low platelets), eclampsia | |||
haemolytic uraemic syndrome | |||
Drugs: quinine, simvastatin, interferon, Calcineurin inhibitors | |||
Malignant hypertension | |||
Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus) | |||
Severe bacterial (meningococcus, pneumococcus) | |||
Fungal Autoimmune disease (lupus nephritis, acute scleroderma) | |||
Vasculitis Haemolytic uraemic syndrome (diarrhoea positive/negative) | |||
Malignancy Catastrophic antiphospholipid syndrom | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Differential Diagnosis
The main differential diagnosis of TTP is hemolytic-uremic syndrome (HUS: which has neurosymptoms, renal failure, hypertension and fever). Note that ADAMTS13 activity is normal in HUS.[1]
TTP must be differentiated from
- TMA syndromes
- Disseminated Intravascular Coagulation
- Hypertension
- Immune Thrombocytopenic Purpura (ITP)
- Malignant Hypertension
- Hematological abnormalities
- Ischemic manifestations linked to autoimmune diseases
Differentiating TTP from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]
On the basis [symptom 1], [symptom 2], and [symptom 3],TTP must be differentiated from
Autoimmune haemolysis
Evans syndrome Disseminated intravascular coagulation Pregnancy-associated such as: HELLP (haemolysis, elevated liver enzymes and low platelets), eclampsia
haemolytic uraemic syndrome
Drugs: quinine, simvastatin, interferon, Calcineurin inhibitors
Malignant hypertension
Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus)
Severe bacterial (meningococcus, pneumococcus)
Fungal Autoimmune disease (lupus nephritis, acute scleroderma)
Vasculitis Haemolytic uraemic syndrome (diarrhoea positive/negative)
Malignancy Catastrophic antiphospholipid syndrom
References
- ↑ Joly, Bérangère S.; Coppo, Paul; Veyradier, Agnès (2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–2846. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971.