Thrombotic thrombocytopenic purpura history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
*The hallmark of TTP is such as clinical findings HUS. | |||
*The hallmark of | |||
===History=== | ===History=== | ||
Patients with | Patients with TTP may have a positive history of:<ref name="pmid22624596">{{cite journal |vauthors=Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, Cheung B, Machin SJ |title=Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies |journal=Br. J. Haematol. |volume=158 |issue=3 |pages=323–35 |date=August 2012 |pmid=22624596 |doi=10.1111/j.1365-2141.2012.09167.x |url=}}</ref> | ||
{| class="wikitable" | |||
|+ | |||
! colspan="2" |Clinical history of TTP | |||
|- | |||
|Thrombocytopenia | |||
|Epistaxis, bruising, petechiae, gingival bleeding, haematuria, menorrhagia, gastrointestinal bleeding, retinal haemorrhage and haemoptysis | |||
|- | |||
|Central neurological | |||
|Confusion, headache, paresis, aphasia, dysarthria, visual problems, encephalopathy, coma (10%) | |||
|- | |||
|Renal Impairment | |||
|Proteinuria, microhaematuria | |||
|- | |||
|Non-specific symptoms | |||
|Pallor, jaundice, fatigue, arthralgia or myalgia | |||
|- | |||
|Jaundice | |||
|Resulting from microangiopathic haemolytic anaemia | |||
|- | |||
|Cardiac | |||
|Chest pain, heart failure, hypotension | |||
|- | |||
|Gastro-intestinal tract(GI) | |||
|Abdominal pain | |||
|} | |||
===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of [disease] include: | Common symptoms of [disease] include:<ref name="pmid23294213">{{cite journal| author=Griffin D, Al-Nouri ZL, Muthurajah D, Ross JR, Ballard RB, Terrell DR et al.| title=First symptoms in patients with thrombotic thrombocytopenic purpura: what are they and when do they occur? | journal=Transfusion | year= 2013 | volume= 53 | issue= 1 | pages= 235-7 | pmid=23294213 | doi=10.1111/j.1537-2995.2012.03934.x | pmc=3541531 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23294213 }}</ref> | ||
*History of autoimmune disease like SLE | |||
=== | |||
== | |||
* History of autoimmune disease like SLE | |||
* History of surgery or transplant | * History of surgery or transplant | ||
* Drug history | * Drug history | ||
* Initial symptoms: Fatigue, pale and/or red skin, shortness of breath, bruises, bleeding | * Initial symptoms: Fatigue, pale and/or red skin, shortness of breath, bruises, bleeding | ||
* Headache | * Headache | ||
* Numbness | * Numbness | ||
| Line 48: | Line 56: | ||
* Fever | * Fever | ||
* Changes in the urine | * Changes in the urine | ||
* Chills | ===Less Common Symptoms=== | ||
Less common symptoms of TTP include: | |||
*Chills | |||
* Chest pain | * Chest pain | ||
* Cough | * Cough | ||
Revision as of 16:40, 14 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
The majority of patients with [disease name] are asymptomatic.
OR
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
- The hallmark of TTP is such as clinical findings HUS.
History
Patients with TTP may have a positive history of:[1]
| Clinical history of TTP | |
|---|---|
| Thrombocytopenia | Epistaxis, bruising, petechiae, gingival bleeding, haematuria, menorrhagia, gastrointestinal bleeding, retinal haemorrhage and haemoptysis |
| Central neurological | Confusion, headache, paresis, aphasia, dysarthria, visual problems, encephalopathy, coma (10%) |
| Renal Impairment | Proteinuria, microhaematuria |
| Non-specific symptoms | Pallor, jaundice, fatigue, arthralgia or myalgia |
| Jaundice | Resulting from microangiopathic haemolytic anaemia |
| Cardiac | Chest pain, heart failure, hypotension |
| Gastro-intestinal tract(GI) | Abdominal pain |
Common Symptoms
Common symptoms of [disease] include:[2]
- History of autoimmune disease like SLE
- History of surgery or transplant
- Drug history
- Initial symptoms: Fatigue, pale and/or red skin, shortness of breath, bruises, bleeding
- Headache
- Numbness
- Weakness
- Dizziness
- Palpitation
- Abdominal pain
- Easy bruising
- Nausea and vomiting
- Fever
- Changes in the urine
Less Common Symptoms
Less common symptoms of TTP include:
- Chills
- Chest pain
- Cough
References
- ↑ Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, Cheung B, Machin SJ (August 2012). "Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies". Br. J. Haematol. 158 (3): 323–35. doi:10.1111/j.1365-2141.2012.09167.x. PMID 22624596.
- ↑ Griffin D, Al-Nouri ZL, Muthurajah D, Ross JR, Ballard RB, Terrell DR; et al. (2013). "First symptoms in patients with thrombotic thrombocytopenic purpura: what are they and when do they occur?". Transfusion. 53 (1): 235–7. doi:10.1111/j.1537-2995.2012.03934.x. PMC 3541531. PMID 23294213.