Thrombotic thrombocytopenic purpura differential diagnosis: Difference between revisions
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===Differentiating TTP from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]=== | ===Differentiating TTP from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]=== | ||
On the basis | On the basis rombocytopenia, MAHA, fluctuating neurological signs, renal faluer and fever, TTP must be differentiated from<ref name="KarpmanLoos2017">{{cite journal|last1=Karpman|first1=Diana|last2=Loos|first2=Sebastian|last3=Tati|first3=Ramesh|last4=Arvidsson|first4=Ida|title=Haemolytic uraemic syndrome|journal=Journal of Internal Medicine|volume=281|issue=2|year=2017|pages=123–148|issn=09546820|doi=10.1111/joim.12546}}</ref> | ||
* Autoimmune haemolysis | |||
* Evans syndrome Disseminated intravascular coagulation Pregnancy-associated such as: HELLP (haemolysis, elevated liver enzymes and low platelets), eclampsia | |||
Autoimmune haemolysis | * haemolytic uraemic syndrome | ||
* Drugs: quinine, simvastatin, interferon, Calcineurin inhibitors | |||
Evans syndrome Disseminated intravascular coagulation Pregnancy-associated such as: HELLP (haemolysis, elevated liver enzymes and low platelets), eclampsia | * Malignant hypertension | ||
* Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus) | |||
haemolytic uraemic syndrome | * Severe bacterial (meningococcus, pneumococcus) | ||
* Fungal Autoimmune disease (lupus nephritis, acute scleroderma) | |||
Drugs: quinine, simvastatin, interferon, Calcineurin inhibitors | * Vasculitis Haemolytic uraemic syndrome (diarrhoea positive/negative) | ||
* Malignancy Catastrophic antiphospholipid syndrom | |||
Malignant hypertension | |||
Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus) | |||
Severe bacterial (meningococcus, pneumococcus) | |||
Fungal Autoimmune disease (lupus nephritis, acute scleroderma) | |||
Vasculitis Haemolytic uraemic syndrome (diarrhoea positive/negative) | |||
Malignancy Catastrophic antiphospholipid syndrom | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Differential Diagnosis
The main differential diagnosis of TTP is hemolytic-uremic syndrome (HUS: which has neurosymptoms, renal failure, hypertension and fever). Note that ADAMTS13 activity is normal in HUS.[1]
TTP must be differentiated from
- TMA syndromes
- Disseminated Intravascular Coagulation
- Hypertension
- Immune Thrombocytopenic Purpura (ITP)
- Malignant Hypertension
- Hematological abnormalities
- Ischemic manifestations linked to autoimmune diseases
Differentiating TTP from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]
On the basis rombocytopenia, MAHA, fluctuating neurological signs, renal faluer and fever, TTP must be differentiated from[2]
- Autoimmune haemolysis
- Evans syndrome Disseminated intravascular coagulation Pregnancy-associated such as: HELLP (haemolysis, elevated liver enzymes and low platelets), eclampsia
- haemolytic uraemic syndrome
- Drugs: quinine, simvastatin, interferon, Calcineurin inhibitors
- Malignant hypertension
- Infections (typically viral (cytomegalovirus, adenovirus, herpes simplex virus)
- Severe bacterial (meningococcus, pneumococcus)
- Fungal Autoimmune disease (lupus nephritis, acute scleroderma)
- Vasculitis Haemolytic uraemic syndrome (diarrhoea positive/negative)
- Malignancy Catastrophic antiphospholipid syndrom
References
- ↑ Joly, Bérangère S.; Coppo, Paul; Veyradier, Agnès (2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–2846. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971.
- ↑ Karpman, Diana; Loos, Sebastian; Tati, Ramesh; Arvidsson, Ida (2017). "Haemolytic uraemic syndrome". Journal of Internal Medicine. 281 (2): 123–148. doi:10.1111/joim.12546. ISSN 0954-6820.