Sandbox:Hannan

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2]

Overview

Vascular Anomalies
Vascular Tumors	Vascular Malformations
Benign Locally aggressive or Borderline Malignant	Simple	Combined°	of major named vessels	associated with other anomalies
	Capillary malformations Lymphatic malformations Venous malformations Arteriovenous malformations* Arteriovenous fistula*	Capillary venous malformation , Capillary lymphatic malformation Lymphatic venous malformation, Capillary lymphatic venous malformation Capillary arteriovenous malformation Capillary lymphatic arteriovenous malformation others	See details	See list

° defined as two or more vascular malformations found in one lesion

* high flow lesions

Classification

Classification of Vascular Tumors

Vascular tumors

Benign

Locally aggressive or borderline

Malignant

Infantile hemangioma / Hemangioma of infancy

Kaposiform hemangioendothelioma*

Angiosarcoma

Congenital hemangioma*

Retiform hemangioendothelioma

Epithelioid hemangioendothelioma

Tufted angioma*

Papillary intralymphatic angioendothelioma (PILA), Dabska tumor

Others

Spindle-cell hemangioma

Composite hemangioendothelioma

Epithelioid hemangioma

Pseudomyogenic hemangioendothelioma

Pyogenic granuloma (also known as lobular capillary hemangioma)

Polymorphous hemangioendothelioma

Others Hobnail hemangioma Microvenular hemangioma Anastomosing hemangioma Glomeruloid hemangioma Papillary hemangioma Intravascular papillary endothelial hyperplasia Cutaneous epithelioid angiomatous nodule Acquired elastotic hemangioma Littoral cell hemangioma of the spleen

Hemangioendothelioma not otherwise specified

Related lesions Eccrine angiomatous hamartoma Reactive angioendotheliomatosis Bacillary angiomatosis

Kaposi sarcoma

Others

^*congenital hemangioma (rapidly involuting type) and tufted angioma may be associated with thrombocytopenia and/or consumptive coagulopathy in some cases.

°many experts consider tufted angioma and kaposiform hemangioendothelioma to be part of a spectrum rather than distinct entities

Classification of Vascular Malformations

Vascular malformations

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Anomalies of major named vessels (also known as "channel type" or "truncal" vascular malformations)

Affect lymphatics veins arteries Anomalies of origin course number length diameter (aplasia, hypoplasia, stenosis, ectasia / aneurysm) valves communication (AVF) persistence (of embryonal vessel) Combined vascular malformations* CM + VM capillary-venous malformation CVM CM + LM capillary-lymphatic malformation CLM CM + AVM capillary-arteriovenous malformation CAVM LM + VM lymphatic-venous malformation LVM CM + LM + VM capillary-lymphatic-venous malformation CLVM CM + LM + AVM capillary-lymphatic-arteriovenous malformation CLAVM CM + VM + AVM capillary-venous-arteriovenous malformation CVAVM CM + LM + VM + AVM capillary-lymphatic-venous-arteriovenous m. CLVAVM Vascular malformations associated with other anomalies Klippel-Trenaunay syndrome * CM + VM +/-LM + limb overgrowth Parkes Weber syndrome CM + AVF + limb overgrowth Servelle-Martorell syndrome limb VM + bone undergrowth Sturge-Weber syndrome facial + leptomeningeal CM + eye anomalies +/-bone and/or soft tissue overgrowth Limb CM + congenital non-progressive limb overgrowth Maffucci syndrome VM +/-spindle-cell hemangioma + enchondroma Macrocephaly-CM (M-CM / MCAP) * Microcephaly-CM (MICCAP) CLOVES syndrome * LM + VM + CM +/-AVM+ lipomatous overgrowth Proteus syndrome CM, VM and/or LM + asymmetrical somatic overgrowth Bannayan-Riley-Ruvalcaba sd lower lip CM + face and neck LM + asymmetry and partial/generalized overgrowth Pathogenesis of xxx disease is due to: yyy zzz aaa vvv Physiology Medical Therapy Naural History Historical Perspective