Sandbox:iqra

Splenomegaly differential:

Category	Disease		Etiology	Clinical manifestations												Para−clinical findings										Gold standard	Associated findings
				Demography	History	Symptoms					Signs					Lab Findings									Imaging
						Fever	Fatigue	Weight loss	SOB	Bleeding	BP	JVP	Jaundice	Ascites	Other	CBC			PS	Iron	LFT	PT/PTT	BUN/Cr	UA
																WBC	Hb	Plt
Congestive	Cirrhosis
	Heart failure
	Thrombosis of portal, hepatic, or splenic veins
Malignancy	Lymphoma
	Leukemias
	Polycythemia vera
	Multiple myeloma
	Essential thrombocythemia
	Primary myelofibrosis
	Primary splenic tumors
	Metastatic solid tumors
Infection	Viral	Hepatitis, infectious mononucleosis, cytomegalovirus
	Bacterial	Salmonella, Brucella, tuberculosis
	Parasitic	Malaria, schistosomiasis, toxoplasmosis
		Kala-azar (visceral leishmaniasis)
	Infective endocarditis
	Fungal
Inflammation	Sarcoid
	Serum sickness
	Systemic lupus erythematosus
	Felty syndrome
Infiltrative	Gaucher disease
	Niemann-Pick disease
	Amyloidosis
	Langerhans cell histiocytosis
	Hemophagocytic lymphohistiocytosis
	Rosai-Dorfman disease
Hematologic (hypersplenic) states	Hemolytic anemia
	Sickle cell disease
	Granulocyte colony-stimulating factor
Category	Disease		Etiology	Demography	History	Fever	Fatigue	Weight loss	SOB	Bleeding	BP	JVP	Jaundice	Ascites	Other	WBC	Hb	Plt	PS	Iron	LFT	PT/PTT	BUN/Cr	UA	Imaging	Gold standard	Associated findings