Ameloblastoma causes: Difference between revisions
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== Genetic Causes == | == Genetic Causes == | ||
* Ameloblastoma is caused by a mutation in the ''FGFR2-RAS-BRAF V600E'' gene.<ref name="pmid24993163">{{cite journal |vauthors=Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL |title=Activating FGFR2-RAS-BRAF mutations in ameloblastoma |journal=Clin. Cancer Res. |volume=20 |issue=21 |pages=5517–26 |date=November 2014 |pmid=24993163 |doi=10.1158/1078-0432.CCR-14-1069 |url=}}</ref> | * Ameloblastoma is caused by a mutation in the ''FGFR2-RAS-BRAF V600E'' gene.<ref name="pmid24993163">{{cite journal |vauthors=Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL |title=Activating FGFR2-RAS-BRAF mutations in ameloblastoma |journal=Clin. Cancer Res. |volume=20 |issue=21 |pages=5517–26 |date=November 2014 |pmid=24993163 |doi=10.1158/1078-0432.CCR-14-1069 |url=}}</ref><ref name="pmid24374844">{{cite journal |vauthors=Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K |title=High frequency of BRAF V600E mutations in ameloblastoma |journal=J. Pathol. |volume=232 |issue=5 |pages=492–8 |date=April 2014 |pmid=24374844 |pmc=4255689 |doi=10.1002/path.4317 |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 16:30, 28 September 2018
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Ameloblastoma causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of ameloblastoma, or it is may be due to increased expression of α5β1 integrin which participate in the local invasiveness of ameloblastoma.
Causes
- There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro.
- There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas.
- A recent study discovered a high frequency of BRAF V600E mutations in solid/multicystic ameloblastoma.
- These data suggests drugs targeting mutant BRAF as potential novel therapies for ameloblastoma.
Genetic Causes
References
- ↑ Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL (November 2014). "Activating FGFR2-RAS-BRAF mutations in ameloblastoma". Clin. Cancer Res. 20 (21): 5517–26. doi:10.1158/1078-0432.CCR-14-1069. PMID 24993163.
- ↑ Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K (April 2014). "High frequency of BRAF V600E mutations in ameloblastoma". J. Pathol. 232 (5): 492–8. doi:10.1002/path.4317. PMC 4255689. PMID 24374844.