Ameloblastoma causes: Difference between revisions
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{{CMG}}{{AE}}{{Simrat}} | {{CMG}}{{AE}}{{Simrat}} | ||
==Overview== | ==Overview== | ||
There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of [[ameloblastoma]], or it is may be due to increased expression of α5β1 [[integrin]] which participate in the local invasiveness of [[ameloblastoma]]. | There are no established causes for [[ameloblastoma]]. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of [[ameloblastoma]], or it is may be due to increased expression of α5β1 [[integrin]] which participate in the local invasiveness of [[ameloblastoma]]. | ||
==Causes== | ==Causes== | ||
* | The cause of [[ameloblastoma]] has not been identified | ||
=== Common Causes === | |||
* | * Decreased expression of of matrix metalloproteinase-2<ref name="JeddyJeeva2013">{{cite journal|last1=Jeddy|first1=Nadeem|last2=Jeeva|first2=Sathiya|last3=Jeyapradha|first3=T|last4=Lakshmipathy|first4=P|last5=Saikrishna|first5=P|last6=Ananthalakshmi|first6=R|title=The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma|journal=Journal of Dr. NTR University of Health Sciences|volume=2|issue=3|year=2013|pages=157|issn=2277-8632|doi=10.4103/2277-8632.117179}}</ref> | ||
* Increased expression α5β1 integrin | |||
== Genetic Causes == | == Genetic Causes == | ||
Revision as of 16:36, 28 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of ameloblastoma, or it is may be due to increased expression of α5β1 integrin which participate in the local invasiveness of ameloblastoma.
Causes
The cause of ameloblastoma has not been identified
Common Causes
- Decreased expression of of matrix metalloproteinase-2[1]
- Increased expression α5β1 integrin
Genetic Causes
References
- ↑ Jeddy, Nadeem; Jeeva, Sathiya; Jeyapradha, T; Lakshmipathy, P; Saikrishna, P; Ananthalakshmi, R (2013). "The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma". Journal of Dr. NTR University of Health Sciences. 2 (3): 157. doi:10.4103/2277-8632.117179. ISSN 2277-8632.
- ↑ Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL (November 2014). "Activating FGFR2-RAS-BRAF mutations in ameloblastoma". Clin. Cancer Res. 20 (21): 5517–26. doi:10.1158/1078-0432.CCR-14-1069. PMID 24993163.
- ↑ Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K (April 2014). "High frequency of BRAF V600E mutations in ameloblastoma". J. Pathol. 232 (5): 492–8. doi:10.1002/path.4317. PMC 4255689. PMID 24374844.