Sandbox:Zahir

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Algorithm

{{{ A01 }}}

{{{ B01 }}}

{{{ B02 }}}

Pathophysiology

Pathology

• AAA
• BBB
  • CCC

• abc
• def

Diseases		A	B
ABC	Type 1
	Type 2
DEF

Algorithm

Combined Immunodeficiencies Generally Less Pronounced than Severe Combined Immunodeficiency

Low CD4: MHC II Expression?

Low CD8

Low B Cells

Ig: Often Normal

Ig Low

Normal Ig but Low Specific Antibody Response

Absent: MHCII Deficiency

Present: XL: MAGT 1 Def:, AR: LCK Def:, AD: UNC119 Def:

IL2IR Def:

MALT1 Def:

CD8 def:

ZAP70 def:

MHC1 def:

DOCK8 def:

MST1 def:

IL21 def:

NIK def:

Moesin def:

CD3Y def:

RHOH def:

TCR alpha def:

BCL11B def:

OX40 def:

LAT def

DOCK2 def:

CARDII def:(LOF)

BCL10 def:

IKBKB Def:

ICOS def:

TFRC def:

RelB def:

CD40 ligand def:(CD154)