Palmar plantar erythrodysesthesia causes: Difference between revisions

Jump to navigation Jump to search
← Older editNewer edit →
VisualWikitext
Zain (talk | contribs)
103 edits
Mchitsazan (talk | contribs)
nocaptcha, smwadministrator, Administrators
199 edits
Line 7: Line 7:


==Causes==
==Causes==
Chemotherapy drugs that can cause this syndrome include:
'''Most frequently associated:'''
* Cytarabine<sup>13,14</sup> (Cytosar-U)
* Docetaxel<sup>15,16</sup> (Docefrez, Taxotere)
* Doxorubicin (Adriamycin)<sup>17,18</sup> and liposomal-encapsulated doxorubicin<sup>19-25</sup> (Doxil)
* 5-Fluorouracil<sup>26-41</sup> (5-FU, Adrucil)
* Capecitabine<sup>8,42-47</sup> (Xeloda)
* Sorafenib <ref name="pmid21537373">{{cite journal| author=Farr KP, Safwat A| title=Palmar-plantar erythrodysesthesia associated with chemotherapy and its treatment. | journal=Case Rep Oncol | year= 2011 | volume= 4 | issue= 1 | pages= 229-35 | pmid=21537373 | doi=10.1159/000327767 | pmc=3085037 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21537373  }} </ref>
'''Less frequently associated:'''
* Cisplatin<sup>48</sup>
* Cyclophosphamide<sup>49</sup>
* Daunorubicin and liposomal daunorubicin<sup>50</sup>
* Doxifluridine
* Etoposide<sup>51-54</sup>
* Floxuridine<sup>55</sup>    (FUDF)
* Hydroxyurea<sup>56,57</sup>    (hydroxycarbamide)
* 6-Mercaptopurine<sup>9</sup>
* Methotrexate<sup>58-63</sup>
* Mitotane<sup>1</sup>
* Paclitaxel<sup>64-67</sup> (Taxol)
* Tegafur<sup>68-70</sup>
* Vinorelbine<sup>71-74</sup>
* Idarubicin (Idamycin)
* Vemurafenib<sup>75</sup> (Zelboraf)
* 6-thioguanine<sup>76</sup>
Commonly associated chemotherapeutic agents are listed below:
Commonly associated chemotherapeutic agents are listed below:
* Most frequently associated with Doxorubicin (Pegylated liposomal Doxorubicin), 5-Flurouracil, and Cytarabine<ref name="pmid17350337">{{cite journal| author=Webster-Gandy JD, How C, Harrold K| title=Palmar-plantar erythrodysesthesia (PPE): a literature review with commentary on experience in a cancer centre. | journal=Eur J Oncol Nurs | year= 2007 | volume= 11 | issue= 3 | pages= 238-46 | pmid=17350337 | doi=10.1016/j.ejon.2006.10.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17350337  }}</ref>.
* Most frequently associated with Doxorubicin (Pegylated liposomal Doxorubicin), 5-Flurouracil, and Cytarabine<ref name="pmid17350337">{{cite journal| author=Webster-Gandy JD, How C, Harrold K| title=Palmar-plantar erythrodysesthesia (PPE): a literature review with commentary on experience in a cancer centre. | journal=Eur J Oncol Nurs | year= 2007 | volume= 11 | issue= 3 | pages= 238-46 | pmid=17350337 | doi=10.1016/j.ejon.2006.10.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17350337  }}</ref>.
* Methotrexate - even low dose used to treat ALL<ref name="pmid1441532">{{cite journal| author=Wysocki M, Nowaczyk-Michalak A, Pilecki O, Kurylak A, Balcar-Boroń A, Trybuś L| title=[Burgdorf's reaction (painful acral erythema) in patients with acute lymphoblastic leukemia following medium-dose methotrexate therapy]. | journal=Wiad Lek | year= 1992 | volume= 45 | issue= 11-12 | pages= 462-4 | pmid=1441532 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1441532  }}</ref>
* Methotrexate - even low dose used to treat ALL<ref name="pmid1441532">{{cite journal| author=Wysocki M, Nowaczyk-Michalak A, Pilecki O, Kurylak A, Balcar-Boroń A, Trybuś L| title=[Burgdorf's reaction (painful acral erythema) in patients with acute lymphoblastic leukemia following medium-dose methotrexate therapy]. | journal=Wiad Lek | year= 1992 | volume= 45 | issue= 11-12 | pages= 462-4 | pmid=1441532 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1441532  }}</ref>
Line 14: Line 46:


'''<big>Less Common Causes</big>'''<ref name="pmid10071309">{{cite journal| author=Susser WS, Whitaker-Worth DL, Grant-Kels JM| title=Mucocutaneous reactions to chemotherapy. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 3 | pages= 367-98; quiz 399-400 | pmid=10071309 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10071309  }}</ref>
'''<big>Less Common Causes</big>'''<ref name="pmid10071309">{{cite journal| author=Susser WS, Whitaker-Worth DL, Grant-Kels JM| title=Mucocutaneous reactions to chemotherapy. | journal=J Am Acad Dermatol | year= 1999 | volume= 40 | issue= 3 | pages= 367-98; quiz 399-400 | pmid=10071309 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10071309  }}</ref>
* Cisplatin
* Cisplatin
* Cyclophosphamide
* Cyclophosphamide

Revision as of 13:53, 27 June 2019

Palmar plantar erythrodysesthesia Microchapters

Home

Overview

Historical perspective

Classification

Pathophysiology

Causes

Differentiating Palmar plantar erythrodysesthesia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural history, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Palmar plantar erythrodysesthesia causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Palmar plantar erythrodysesthesia causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Palmar plantar erythrodysesthesia causes

CDC on Palmar plantar erythrodysesthesia causes

Palmar plantar erythrodysesthesia causes in the news

Blogs on Palmar plantar erythrodysesthesia causes

Directions to Hospitals Treating Palmar plantar erythrodysesthesia

Risk calculators and risk factors for Palmar plantar erythrodysesthesia causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Several different Chemotherapeutic agents have been associated with acral erythema[1]

Causes

Chemotherapy drugs that can cause this syndrome include:

Most frequently associated:

  • Cytarabine13,14 (Cytosar-U)
  • Docetaxel15,16 (Docefrez, Taxotere)
  • Doxorubicin (Adriamycin)17,18 and liposomal-encapsulated doxorubicin19-25 (Doxil)
  • 5-Fluorouracil26-41 (5-FU, Adrucil)
  • Capecitabine8,42-47 (Xeloda)
  • Sorafenib [2]

Less frequently associated:

  • Cisplatin48
  • Cyclophosphamide49
  • Daunorubicin and liposomal daunorubicin50
  • Doxifluridine
  • Etoposide51-54
  • Floxuridine55 (FUDF)
  • Hydroxyurea56,57 (hydroxycarbamide)
  • 6-Mercaptopurine9
  • Methotrexate58-63
  • Mitotane1
  • Paclitaxel64-67 (Taxol)
  • Tegafur68-70
  • Vinorelbine71-74
  • Idarubicin (Idamycin)
  • Vemurafenib75 (Zelboraf)
  • 6-thioguanine76


Commonly associated chemotherapeutic agents are listed below:

  • Most frequently associated with Doxorubicin (Pegylated liposomal Doxorubicin), 5-Flurouracil, and Cytarabine[3].
  • Methotrexate - even low dose used to treat ALL[4]
  • Mitotane[5]
  • PLD, Docetaxel, Capecitabine, vinorelbine, gemcitabine and Sorafenib[2]

Less Common Causes[6]

  • Cisplatin
  • Cyclophosphamide
  • Daunorubicin
  • Doxifluridine
  • Etoposide
  • Floxuridine
  • Hydroxyurea
  • Idarubicin
  • Lomustine
  • Melphalan
  • Mercaptopurine
  • Mitomycin
  • Paclitaxel
  • Suramin
  • Troxacitabine[7]
  • Tegafur
  • Vincristine

Genetics

No genetic association has been found as of yet as the data on this condition is limited.

References

  1. ↑ Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
  2. ↑ 2.0 2.1 Farr KP, Safwat A (2011). "Palmar-plantar erythrodysesthesia associated with chemotherapy and its treatment". Case Rep Oncol. 4 (1): 229–35. doi:10.1159/000327767. PMC 3085037. PMID 21537373.
  3. ↑ Webster-Gandy JD, How C, Harrold K (2007). "Palmar-plantar erythrodysesthesia (PPE): a literature review with commentary on experience in a cancer centre". Eur J Oncol Nurs. 11 (3): 238–46. doi:10.1016/j.ejon.2006.10.004. PMID 17350337.
  4. ↑ Wysocki M, Nowaczyk-Michalak A, Pilecki O, Kurylak A, Balcar-Boroń A, Trybuś L (1992). "[Burgdorf's reaction (painful acral erythema) in patients with acute lymphoblastic leukemia following medium-dose methotrexate therapy]". Wiad Lek. 45 (11–12): 462–4. PMID 1441532.
  5. ↑ Zuehlke RL (1974). "Erythematous eruption of the palms and soles associated with mitotane therapy". Dermatologica. 148 (2): 90–2. PMID 4276191.
  6. ↑ Susser WS, Whitaker-Worth DL, Grant-Kels JM (1999). "Mucocutaneous reactions to chemotherapy". J Am Acad Dermatol. 40 (3): 367–98, quiz 399-400. PMID 10071309.
  7. ↑ Hidalgo M, Siu LL, Nemunaitis J, Rizzo J, Hammond LA, Takimoto C; et al. (2001). "Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies". J Clin Oncol. 19 (13): 3267–79. doi:10.1200/JCO.2001.19.13.3267. PMID 11432895.
Retrieved from "https://www.wikidoc.org/index.php?title=Palmar_plantar_erythrodysesthesia_causes&oldid=1573780"