Sandbox:Zahir: Difference between revisions

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{{CMG}}; {{AE}}{{ZAS}}
{{CMG}}; {{AE}}{{ZAS}}


==Algorithm==
==Differentiating [Disease name] from other Diseases==
{{familytree/start}}
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
{{familytree | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | | | |A01=Diseases Of Immune Dysregulation:(A) Hemophagocytic Lymphohistiocytosis (HLH) & EBV Susceptibility }}
{{familytree | | | | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | B01 | | | | | | | | | | B02 | | | | | | | | | | | | | | |B01=Hemophagocytic Lymphohistiocytosis(HLH)|B02=Susceptibility to EBV }}
{{familytree | | | | |,|-|-|^|-|-|.| | | | | |,|-|-|^|-|-|.| | | | | | | | | | | | |}}
{{familytree | | | | C01 | | | | C02 | | | | |!| | | | | C03 | | | | | | | | | | | |C01=Hypopigmentation|C02=Familial Hemophagocytic Lymphohistiocytosis Syndromes|C03=EBV Associated with HLH }}
{{familytree | | | | |!| | | | |!| | | | | | |!| | | | |!| | | | | | | | | | | | | |}}
{{familytree | | | | |)| D01 | |)| D02 | | | |)| D03 | |)| D04 | | | | | | | | | | |D01=Chediak Higashi Syndrome:LYST|D02=Perforin Deficiency(FHL2)|D03=RASGRP1 Deficiency|D04=XL,XLP1.SH2DIA }}
{{familytree | | | | |!| | | | |!| | | | | | |!| | | | |!| | | | | | | | | | | | | |}}
{{familytree | | | | |)| E01 | |)| E02 | | | |)| E03 | |)| E04 | | | | | | | | | | |E01=Griscelli Syndrome type2:RAB27a|E02=UNCBD/Munc13-4 deficiency(FHL3)|E03=CD70 Deficiency|E04=XL,XLP2,XIAP }}
{{familytree | | | | |!| | | | |!| | | | | | |!| | | | |!| | | | | | | | | | | | | |}}
{{familytree | | | | |)| F01 | |)| F02 | | | |)| F03 | |)| F04 | | | | | | | | | | |F01=Hermansky Pudlak Syndrome type2:AP3B1|F02=Syntaxin II Deficiency(FHL4)|F03=CTPS1 Deficiency|F04=AR, CD27 Deficiency }}
{{familytree | | | | |!| | | | |!| | | | | | |!| | | | |!| | | | | | | | | | | | | }}
{{familytree | | | | |`| G01 | |`| G02 | | | |)| G03 | |`| G04 | | | | | | | | | | |G01=Hermansky Pudlak Syndrome type10|G02=STXBP2/Munc18-2 Deficiency|G03=RLTPR (CARMIL2) Deficiency|G04=FAAP24 Deficiency }}
{{familytree | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | | | | | | | | | |)| H01 | | | | | | | | | | | | | | | |H01=ITK Deficiency }}
{{familytree | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | | | | | | | | | |)| I01 | | | | | | | | | | | | | | | |I01=MAGT1 Deficiency }}
{{familytree | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | |}}
{{familytree | | | | | | | | | | | | | | | | |`| J01 | | | | | | | | | | | | | | | |J01=PRKCD Deficiency }}
{{familytree/end}}


==Pathophysiology==
OR


===Pathology===
[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].
*AAA
*BBB
**CCC


* abc
OR
* def


{| class="wikitable"
As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].
! colspan="2" |Diseases
 
!A
===Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]===
!B
 
On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].
{|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! rowspan="4"  style="background: #4479BA; color: #FFFFFF; text-align: center;|Diseases
| colspan="6" rowspan="1"  style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Clinical manifestations'''
! colspan="7" rowspan="2"  style="background: #4479BA; color: #FFFFFF; text-align: center;|Para-clinical findings
| colspan="1" rowspan="4"  style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Gold standard'''
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;|Additional findings
|-
| colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|'''Symptoms'''
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical examination
|-
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab Findings
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;|Histopathology
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 1
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Symptom 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 1
! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Physical exam 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 1
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Lab 3
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 1
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;|Imaging 3
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 1
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 2
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 3
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
!Diseases
!Symptom 1
! colspan="1" rowspan="1" |Symptom 2
!Symptom 3
!Physical exam 1
! colspan="1" rowspan="1" |Physical exam 2
!Physical exam 3
!Lab 1
!Lab 2
!Lab 3
!Imaging 1
!Imaging 2
!Imaging 3
!Histopathology
|'''Gold standard'''
!Additional findings
|-
|-
! rowspan="2" |ABC
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 4
|Type 1
| style="background: #F5F5F5; padding: 5px;" |
|
| style="background: #F5F5F5; padding: 5px;" |
|
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
|-
|Type 2
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 5
|
| style="background: #F5F5F5; padding: 5px;" |
|
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
|-
!DEF
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Differential Diagnosis 6
|
| style="background: #F5F5F5; padding: 5px;" |
|
| style="background: #F5F5F5; padding: 5px;" |
|
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|}
|}
==Algorithm==
{{Family tree/start}}
{{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |A01=Combined Immunodeficiencies Generally Less Pronounced than Severe Combined Immunodeficiency }}
{{Family tree | | | | | |,|-|-|-|-|-|v|-|-|-|-|-|-|-|-|v|-|-|-|-|^|-|-|-|v|-|-|-|-|-|-|-|-|-|v|-|-|-|-|-|.| | | | | | | | | | | | }}
{{Family tree | | | | | B01 | | | | B02 | | | | | | | B03 | | | | | | | B04 | | | | | | | | B05 | | | | B06 | | | | | | | | | | |B01=Low CD4: MHC II Expression?|B02=Low CD8|B03=Low B Cells|B04=Ig: Often Normal|B05=Ig Low|B06=Normal Ig but Low Specific Antibody Response}}
{{Family tree | | | |,|-|^|-|.| | | |!| | | | | | | | |!| | | | | | | | |!| | | | | | | | | |!| | | |,|-|^|-|.| | | | | | | | | | }}
{{Family tree | | | C01 | | C02 | | |!| | | | | | | | |!| | | | | | | | |!| | | | | | | | | |!| | | H01 | | H02 | | | | | | | | |C01=Absent: MHCII Deficiency|C02=Present:  XL: MAGT 1 Def:, AR: LCK Def:, AD: UNC119 Def:|H01=IL2IR Def:|H02=MALT1 Def: }}
{{Family tree | | | | | | | | | | | |!| | | | | | | | |!| | | | | | | | |!| | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{Family tree | | | | | | | |,|-|-|-|+|-|-|-|.| | | | |!| | | | | | | | |!| | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{Family tree | | | | | | | D01 | | D02 | | D03 | | | |!| | | | | | | | |!| | | | | | | | | |!| | | | | | | | | | | | | | | | | |D01=CD8 def:|D02=ZAP70 def:|D03=MHC1 def:}}
{{Family tree | | | | | | | | |,|-|-|-|v|-|-|-|v|-|-|-|+|-|-|-|.| | | | |!| | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{Family tree | | | | | | | | E01 | | E02 | | E03 | | E04 | | E05 | | | |!| | | | | | | | | |!| | | | | | | | | | | | | | | | | |E01=DOCK8 def:|E02=MST1 def:|E03=IL21 def:|E04=NIK def:|E05=Moesin def:}}
{{Family tree | | | | | | | | | | | | | |,|-|-|-|v|-|-|-|v|-|-|-|v|-|-|-|+|-|-|-|.| | | | | |!| | | | | | | | | | | | | | | | | | }}
{{Family tree | | | | | | | | | | | | | F01 | | F02 | | F03 | | F04 | | F05 | | F06 | | | | |!| | | | | | | | | | | | | | | | | |F01=CD3Y def:|F02=RHOH def:|F03=TCR alpha def:|F04=BCL11B def:|F05=OX40 def:|F06=LAT def}}
{{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{Family tree | | | | | | | | | | | | | | | | | | | |,|-|-|-|v|-|-|-|v|-|-|-|v|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|.| | | | | | | | | | }}
{{Family tree | | | | | | | | | | | | | | | | | | | G01 | | G02 | | G03 | | G04 | | G05 | | G06 | | G07 | | G08 | | | | | | | | |G01=DOCK2 def:|G02=CARDII def:(LOF)|G03=BCL10 def:|G04=IKBKB Def:|G05=ICOS def:|G06=TFRC def:|G07=RelB def:|G08=CD40 ligand def:(CD154)}}
{{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{Family tree/end}}
==Algorithm==
{{familytree/start}}
{{familytree | | | | | | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01=Diseases of Immune Dysregulation: (B) Syndromes with Autoimmunity and Others }}
{{familytree | | | | | | | | |,|-|-|-|-|-|-|-|-|-|^|-|-|-|-|-|-|-|-|.| | | | | | | | | | | }}
{{familytree | | | | | | | | B01 | | | | | | | | | | | | | | | | | B02 | | | | | | | | | |B01=Syndromes with Autoimmunity|B02=Immune Dysregulation with Colitis: IBD, Normal Tc & Bc }}
{{familytree | | | | | | | | |!| | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | }}
{{familytree | | | | | | | | C01 | | | | | | | | | | | | | | | | | |)| C02 | | | | | | | |C01=Increased CD4-CD8-TCR alpha/beta (Double Negative T cells)|C02=IL10 Deficiency, IL10, AR }}
{{familytree | | |,|-|-|-|-|-|+|-|-|-|-|-|-|-|-|-|-|-|.| | | | | | |!| | | | | | | | | | | }}
{{familytree | | D01 | | | | D02 | | | | | | | | | | D03 | | | | | |)| D04 | | | | | | | |D01=Yes|D02=Occassionally|D03=NO: Regulatory T cells Defects?|D04=IL10Ra Deficiency, IL10RA, AR }}
{{familytree | | |!| | | | | |!| | | | | | | | |,|-|-|^|-|-|.| | | |!| | | | | | | | | | | }}
{{familytree | | |)| E01 | | |)| E02 | | | | | E03 | | | | E04 | | |)| E05 | | | | | | | |E01=ALPS, Autoimmune Lymphoproliferative Syndrome|E02=LRBA Deficiency|E03=NO|E04=YES|E05=IL10Rb Deficiency, IL10RB, RA }}
{{familytree | | |!| | | | | |!| | | | | | | | |!| | | | | |!| | | |!| | | | | | | | | | | }}
{{familytree | | |)| F01 | | |`| F02 | | | | | |)| F03 | | |)| F04 |`| F05 | | | | | | | |F01=ALPS-FAS TNFRSF, AD or AR|F02=STAT3 GOF mutation,STAT3 AD|F03=Autoimmune Polyendocrinopathy with candidiasis & ectodermal dystrophy: APECED (APS-1)|F04=IPEX Immune dysregulation, Polyendocrinopathy,enteropathy,X-linked FOXP-3|F05=NFATS haploinsufficiency, NAFTS, AD }}
{{familytree | | |!| | | | | | | | | | | | | | |!| | | | | |!| | | | | | | | | | | | | | | }}
{{familytree | | |)| G01 | | | | | | | | | | | |)| G02 | | |)| G03 | | | | | | | | | | | |G01=ALPS-FASLG TNFSF6, AR|G02=ITCH Deficiency, ITCH, AR|G03=CD25 Deficiency, IL2RA, AR }}
{{familytree | | |!| | | | | | | | | | | | | | |!| | | | | |!| | | | | | | | | | | | | | | }}
{{familytree | | |)| H01 | | | | | | | | | | | |)| H02 | | |)| H03 | | | | | | | | | | | |H01=ALPS-Caspase10, Casp10, AD|H02=ZAP70 combined hylomorphic and activation mutations, ZAP70, AR|H03=CTLA4 deficiency (ALPSV) CTLA4, AD }}
{{familytree | | |!| | | | | | | | | | | | | | |!| | | | | |!| | | | | | | | | | | | | | | }}
{{familytree | | |)| I01 | | | | | | | | | | | |)| I02 | | |`| I03 | | | | | | | | | | | |I01=ALPS-Caspase8, Casp8, AR|I02=Tripeptidyl-peptidase II deficiency, TPP2, AR|I03=BACH2 deficiency. BACH2, AD }}
{{familytree | | |!| | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | |`| J01 | | | | | | | | | | | |)| J02 | | | | | | | | | | | | | | | | | |J01=FADD deficiency, FADD, AR|J02=JAK1 GOF, JAK1, AD }}
{{familytree | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | |`| K01 | | | | | | | | | | | | | | | | | |K01=Prolidase deficiency. PEPD, AR }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | ||}}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree/end}}
==Algorithm==
{{familytree/start}}
{{familytree | | | | | | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01=Defects in Intrinsic & Innate Immunity: (A) Bacterial and Parasitic Infections }}
{{familytree | | | | |,|-|-|-|-|-|-|-|-|-|-|-|-|-|+|-|-|-|-|-|-|-|-|-|-|-|-|-|.| | | | | | }}
{{familytree | | | | B01 | | | | | | | | | | | | B02 | | | | | | | | | | | | B03 | | | | |B01=Predisposition to Invasive Bacterial Infections (pyrogens)|B02=Predisposition to Parasitic & Fungal Infections|B03=Others }}
{{familytree | | | | |!| | | | | | | | | | |,|-|-|^|-|-|.| | | | | | | | | | |!| | | | | | }}
{{familytree | | | | |)| C01 | | | | | | | |!| | | | | |!| | | | | | | | | | |)| C02 | | |C01=IRAK4 Deficiency, IRAK4, AR, MyD88 Deficiency, MYD88, AR|C02=Osteopetrosis }}
{{familytree | | | | |!| | | | | | | | | | |!| | | | | |!| | | | | | | | | | |!| | | | | | }}
{{familytree | | | | |)| D01 | | | | | | | |)| D02 | | |)| D03 | | | | | | | |)| D04 | | |D01=IRAK-1 Deficiency:IRAK1,XL|D02=Predisposition to mucocutaneous candidiasis(CMC)|D03=CARD9 Deficiency, CARD9, AR|D04=Hyderadenitis Suppurativa }}
{{familytree | | | | |!| | | | | | | | | | |!| | | | | |!| | | | | | | | | | |!| | | | | | }}
{{familytree | | | | |)| E01 | | | | | | | |)| E02 | | |`| E03 | | | | | | | |)| E04 | | |E01=TIRAP Deficiency, TIRAP, AR|E02=STAT1 GOF, STAT1, AD|E03=Trypanosomiasis APOL1, AD|E04=Acute liver failure due to NBAS deficiency, NBAS, AR }}
{{familytree | | | | |!| | | | | | | | | | |!| | | | | | | | | | | | | | | | |!| | | | | | }}
{{familytree | | | | |`| F01 | | | | | | | |)| F02 | | | | | | | | | | | | | |`| F03 | | |F01=Isolated Congenital Asplenia, RPSA, AD; HMOX, AR|F02=IL-17F Deficiency, IL-17F, AD|F03=Acute necrotizing encephalopathy, RANBP2, AD }}
{{familytree | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | |)| G01 | | | | | | | | | | | | | | | | | | | |G01=IL-17RA Deficiency, IL-17RA, AR }}
{{familytree | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | |)| H01 | | | | | | | | | | | | | | | | | | | |H01=IL-17RC Deficiency, IL-17RC, AR }}
{{familytree | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | |`| I01 | | | | | | | | | | | | | | | | | | | |I01=ACT1 Deficiency, ACT1, AR }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree/end}}
==Algorithm==
{{familytree/start}}
{{familytree | | | | | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | | | |A01=Defects in Intrinsic & Innate Immunity: (B) MSMD & Viral Infections }}
{{familytree | | | | | |,|-|-|-|-|-|-|-|-|-|-|-|^|-|-|-|-|-|-|-|-|-|-|-|.| | | | | | | | | | }}
{{familytree | | | | | B01 | | | | | | | | | | | | | | | | | | | | | | B02 | | | | | | | | |B01=Mendelian susceptibility to mycobacterial disease(MSMD)|B02=Predominant susceptibility to viral infections }}
{{familytree | | |,|-|-|^|-|-|.| | | | | | | | | | | | |,|-|-|-|-|-|-|-|+|-|-|-|-|-|-|.| | | }}
{{familytree | | C01 | | | | C02 | | | | | | | | | | | C03 | | | | | | C04 | | | | | C05 | |C01=Severe Phenotypes|C02=Moderate Phenotypes|C03=Epidermodysplasia verruciformis(HPV)|C04=Predisposition to severe viral infections|C05=Herpes simplex encephalitis }}
{{familytree | | |!| | | | | |!| | | | | | | | | | | | |!| | | | | | | |!| | | | | | | | | | }}
{{familytree | | D01 | | | | |)| D02 | | | | | | | | | |)| D03 | | | | |)| D04 | | | | | | |D01=Complete IFNGR1 def: and IFNGR2 def:, IFNGR1,IFNGR2,AR|D02=IL12 & 23 receptor B1 chain def:, IL12P40 def:, STAT1 LOF, Partial IFNYR1 & 2, AD IFNGR1, TyK2 def:|D03=EVER1 def:, TMC6, AR|D04=STAT1 def: (AR LOF)}}
{{familytree | | | | | | | | |!| | | | | | | | | | | | |!| | | | | | | |!| | | | | | | | | | }}
{{familytree | | | | | | | | |`| E01 | | | | | | | | | |)| E02 | | | | |)| E03 | | | | | | |E01=ISG15 def:, ISG15,AR; Macrophage Gp91 Phox def:CYBB,XL,IRG8 def:,IRF8,AD; IRF8 def:, IRF8 AR; RORc def:, ROCR,AR; JACK1(LOF),JAK1,AR|E02=EVER2 def:, TMC8,AR|E03=STAT2 def: (STAT2 AR) }}
{{familytree | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | |!| | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | |`| F01 | | | | |)| F02 | | | | | | |F01=WHIM (Warts, Hypogammaglobulinemia, Infections, Myelokathexis) Syndrome, CXCR4, AD,GOF|F02=IRF7 def: (IRF7,AR) }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |)| G01 | | | | | | |G02=IFNAR2 def: (IFNAR2,AR) }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |)| H01 | | | | | | |H01=CD16 def: (FCGR3A,AR) }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |`| I01 | | | | | | |I01=MDAS def: (LOF), IFIH1,AR }}
{{familytree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree/end}}
==Algorithm==

Revision as of 21:26, 21 January 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Differentiating [Disease name] from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

OR

As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Histopathology
Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3
Differential Diagnosis 1
Differential Diagnosis 2
Differential Diagnosis 3
Diseases Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3 Histopathology Gold standard Additional findings
Differential Diagnosis 4
Differential Diagnosis 5
Differential Diagnosis 6
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