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| [[{{PAGENAME}}#Don'ts|{{fontcolor|#F8F8FF|Don'ts}}]] | | [[{{PAGENAME}}#Don'ts|{{fontcolor|#F8F8FF|Don'ts}}]] |
| |} | | |} |
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| ==Different types of Von-Willebrand diseases==
| |
| {|
| |
| ! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Type of VWD
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Type of factor deficiency
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Prevalence
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inheritance pattern
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |VWF activity
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |RIPA
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Factor VIII
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| |-
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Type 1
| |
| | align="center" style="background:#F5F5F5;" | Quantitative/ partial
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| | align="center" style="background:#F5F5F5;" | 60-70%
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| | align="center" style="background:#F5F5F5;" | AD
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| | align="left" style="background:#F5F5F5;" |
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| * Bleeding severity mild to severe
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| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| |-
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| ! rowspan="4" align="center" style="background:#DCDCDC;" |Type 2
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| ! align="center" style="background:#DCDCDC;" |2A
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| | align="center" style="background:#F5F5F5;" | Qualitative
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| | align="center" style="background:#F5F5F5;" | 10%
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| | align="center" style="background:#F5F5F5;" | AD/AR
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| | align="left" style="background:#F5F5F5;" |
| |
| * Moderate to severe [[bleeding]]
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| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | N or ↓
| |
| |-
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| ! align="center" style="background:#DCDCDC;" |2B
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| | align="center" style="background:#F5F5F5;" | Qualitative
| |
| | align="center" style="background:#F5F5F5;" | 5%
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| | align="center" style="background:#F5F5F5;" | AD
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| | align="left" style="background:#F5F5F5;" |
| |
| * [[Thrombocytopenia]]
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| * Moderate to severe [[bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↑
| |
| | align="center" style="background:#F5F5F5;" | N or ↓
| |
| |-
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| ! align="center" style="background:#DCDCDC;" |2M
| |
| | align="center" style="background:#F5F5F5;" | Qualitative
| |
| | align="center" style="background:#F5F5F5;" | <1%
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| | align="center" style="background:#F5F5F5;" | AD/AR
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| | align="left" style="background:#F5F5F5;" |
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| * Moderate to severe [[bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | N or ↓
| |
| |-
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| ! align="center" style="background:#DCDCDC;" |2N
| |
| | align="center" style="background:#F5F5F5;" | Qualitative
| |
| | align="center" style="background:#F5F5F5;" | <1%
| |
| | align="center" style="background:#F5F5F5;" | AR
| |
| | align="left" style="background:#F5F5F5;" |
| |
| * Clinically similar to [[hemophilia A]] with [[joint]], [[soft tissue]], [[urinary]] [[bleeding]]
| |
| | align="center" style="background:#F5F5F5;" | N
| |
| | align="center" style="background:#F5F5F5;" | N
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| |-
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Type 3
| |
| | align="center" style="background:#F5F5F5;" | Complete deficiency
| |
| | align="center" style="background:#F5F5F5;" | 1-2%
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| | align="center" style="background:#F5F5F5;" | AR
| |
| | align="left" style="background:#F5F5F5;" |
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| * Clinically similar to [[hemophilia A]] with [[joint]] and [[soft tissue]] [[bleeding]]
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| * Severe [[mucosal bleeding]]
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| | align="center" style="background:#F5F5F5;" | Absent
| |
| | align="center" style="background:#F5F5F5;" | ↓
| |
| | align="center" style="background:#F5F5F5;" | Low, 1-10%
| |
| |}
| |
| For more information on Von Willebrand disease, click [[ von willebrand disease | here]].
| |
| <references />
| |