Waldenström's macroglobulinemia risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2] Roukoz A. Karam, M.D.[3]

Overview

Common risk factors in the development of Waldenström macroglobulinemia are monoclonal gammopathy of undetermined significance, heredity, hepatitis C, and autoimmune disorders.

Risk Factors

Common risk factors in the development of Waldenström macroglobulinemia include:

• Monoclonal gammopathy of undetermined significance (MGUS)
  • Pre-existing monoclonal gammopathy of undetermined significance is the most common risk factor for the development of Waldenström's macroglobulinemia.

• Heredity
  • Patients with Waldenström's macroglobulinemia usually have a close relative with the disease or with a related B-cell disease, such as MGUS or certain types of lymphoma or leukemia.

• Hepatitis C
  • Patients with chronic hepatitis C infection are more likely to develop Waldenström macroglobulinemia than general population.

• Autoimmune Diseases
  • Certain autoimmune diseases, such as sjögren syndrome, increase the risk of developing Waldenström macroglobulinemia.