Waldenström's macroglobulinemia history and symptoms: Difference between revisions
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=== Common Symptoms === | === Common Symptoms === | ||
Common symptoms of Waldenström macroglobulinemia include: | Common symptoms of Waldenström macroglobulinemia include:<ref name="pmid12720138">{{cite journal| author=Merlini G, Baldini L, Broglia C, Comelli M, Goldaniga M, Palladini G et al.| title=Prognostic factors in symptomatic Waldenstrom's macroglobulinemia. | journal=Semin Oncol | year= 2003 | volume= 30 | issue= 2 | pages= 211-5 | pmid=12720138 | doi=10.1053/sonc.2003.50064 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12720138 }} </ref><ref name="pmid11736938">{{cite journal| author=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A et al.| title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. | journal=Br J Haematol | year= 2001 | volume= 115 | issue= 3 | pages= 575-82 | pmid=11736938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11736938 }} </ref><ref name="pmid10623712">{{cite journal| author=Dimopoulos MA, Panayiotidis P, Moulopoulos LA, Sfikakis P, Dalakas M| title=Waldenström's macroglobulinemia: clinical features, complications, and management. | journal=J Clin Oncol | year= 2000 | volume= 18 | issue= 1 | pages= 214-26 | pmid=10623712 | doi=10.1200/JCO.2000.18.1.214 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10623712 }} </ref> | ||
* Constitutional B symptoms | * Constitutional B symptoms | ||
** Weakness | ** Weakness | ||
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=== Less Common Symptoms === | === Less Common Symptoms === | ||
Less common symptoms of Waldenström macroglobulinemia include: | Less common symptoms of Waldenström macroglobulinemia include:<ref name="pmid12720138">{{cite journal| author=Merlini G, Baldini L, Broglia C, Comelli M, Goldaniga M, Palladini G et al.| title=Prognostic factors in symptomatic Waldenstrom's macroglobulinemia. | journal=Semin Oncol | year= 2003 | volume= 30 | issue= 2 | pages= 211-5 | pmid=12720138 | doi=10.1053/sonc.2003.50064 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12720138 }} </ref><ref name="pmid11736938">{{cite journal| author=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A et al.| title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. | journal=Br J Haematol | year= 2001 | volume= 115 | issue= 3 | pages= 575-82 | pmid=11736938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11736938 }} </ref> | ||
* Raynaud phenomenon | * Raynaud phenomenon | ||
** Due to cryoglobulinemia | ** Due to cryoglobulinemia | ||
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Hyperviscosity syndrome occurs due to the accumulation of monoclonal IgM proteins in the blood. | Hyperviscosity syndrome occurs due to the accumulation of monoclonal IgM proteins in the blood. | ||
Clinical manifestations of hyperviscosity syndrome occur only if serum viscosity is >4 centipoises and include: | Clinical manifestations of hyperviscosity syndrome occur only if serum viscosity is >4 centipoises and include:<ref name="pmid11736938">{{cite journal| author=García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A et al.| title=Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. | journal=Br J Haematol | year= 2001 | volume= 115 | issue= 3 | pages= 575-82 | pmid=11736938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11736938 }} </ref> | ||
* Retinal [[hemorrhage]] with blurring of vision | * Retinal [[hemorrhage]] with blurring of vision | ||
*[[Vertigo]] | *[[Vertigo]] | ||
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*[[Ataxia]] | *[[Ataxia]] | ||
* Bleeding | * Bleeding | ||
* | * | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 00:29, 31 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Many patients with Waldenström macroglobulinemia are asymptomatic. The disease is subtle and nonspecific. The most common symptoms of Waldenström macroglobulinemia include weakness, anorexia, blurry vision,peripheral neuropathy, and weight loss. Less common symptoms of the disease include bleeding and Raynaud phenomenon.
History and Symptoms
History
- The onset of Waldenström macroglobulinemia is insidious and nonspecific.
- Approximately 25% of patients with WM are asymptomatic upon presenation; their diagnosis is often made incidentally from routine blood tests.[1]
Common Symptoms
Common symptoms of Waldenström macroglobulinemia include:[2][1][3]
- Constitutional B symptoms
- Weakness
- Anorexia
- Weight loss
- Fever
- Peripheral neuropathy
- Blurry vision
Less Common Symptoms
Less common symptoms of Waldenström macroglobulinemia include:[2][1]
- Raynaud phenomenon
- Due to cryoglobulinemia
- Bleeding
- Mental status changes
- Due to infiltration of central nervous system
- Causes Bing-Neel syndrome which includes confusion, memory loss, and motor abnormalities
- Diarrhea/steatorrhea
- Due to deposition of IgM protein in the lamina propria of the intestinal wall
Symptoms Secondary to Hyperviscosity
Hyperviscosity syndrome occurs due to the accumulation of monoclonal IgM proteins in the blood.
Clinical manifestations of hyperviscosity syndrome occur only if serum viscosity is >4 centipoises and include:[1]
- Retinal hemorrhage with blurring of vision
- Vertigo
- Dizziness
- Headache
- Nystagmus
- Tinnitus
- Ataxia
- Bleeding
References
- ↑ 1.0 1.1 1.2 1.3 García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A; et al. (2001). "Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases". Br J Haematol. 115 (3): 575–82. PMID 11736938.
- ↑ 2.0 2.1 Merlini G, Baldini L, Broglia C, Comelli M, Goldaniga M, Palladini G; et al. (2003). "Prognostic factors in symptomatic Waldenstrom's macroglobulinemia". Semin Oncol. 30 (2): 211–5. doi:10.1053/sonc.2003.50064. PMID 12720138.
- ↑ Dimopoulos MA, Panayiotidis P, Moulopoulos LA, Sfikakis P, Dalakas M (2000). "Waldenström's macroglobulinemia: clinical features, complications, and management". J Clin Oncol. 18 (1): 214–26. doi:10.1200/JCO.2000.18.1.214. PMID 10623712.