Waldenström's macroglobulinemia bone marrow aspiration and biopsy: Difference between revisions
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==Overview== | ==Overview== | ||
A [[bone marrow aspiration]] | A [[bone marrow aspiration]] is essential in the diagnosis of Waldenström macroglobulinemia. | ||
==Bone Marrow Aspirate== | ==Bone Marrow Aspirate== | ||
A [[Bone marrow aspiration|bone marrow aspirate]] | A [[Bone marrow aspiration|bone marrow aspirate]] is essential in the diagnosis of Waldenström macroglobulinemia. | ||
Findings suggestive of Waldenström macroglobulinemia include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | Findings suggestive of Waldenström macroglobulinemia include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | ||
* A hypocellular bone marrow aspirate | * A hypocellular bone marrow aspirate | ||
* Lymphoplasmacytic infiltrate with characteristic immunophenotype | |||
== Bone Marrow Biopsy == | == Bone Marrow Biopsy == | ||
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* Hypercellular and [[Infiltration (medical)|infiltrated]] with [[lymphoid]] and [[Plasmacytoid|plasmacytoid cells]]. | * Hypercellular and [[Infiltration (medical)|infiltrated]] with [[lymphoid]] and [[Plasmacytoid|plasmacytoid cells]]. | ||
* Dutcher bodies (PAS positive | * Dutcher bodies (PAS positive intranuclear vacuoles containing IgM monoclonal protein) | ||
** Characteristic feature of Waldenström macroglobulinemia | ** Characteristic feature of Waldenström macroglobulinemia | ||
Three patterns of marrow involvement are described, as follows: | Three patterns of marrow involvement are described, as follows: | ||
* Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern | * Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern | ||
Revision as of 20:25, 3 January 2019
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]
Overview
A bone marrow aspiration is essential in the diagnosis of Waldenström macroglobulinemia.
Bone Marrow Aspirate
A bone marrow aspirate is essential in the diagnosis of Waldenström macroglobulinemia.
Findings suggestive of Waldenström macroglobulinemia include:[1]
- A hypocellular bone marrow aspirate
- Lymphoplasmacytic infiltrate with characteristic immunophenotype
Bone Marrow Biopsy
A bone marrow biopsy may be helpful in the diagnosis of Waldenström macroglobulinemia. [1]
Findings on the biopsy suggestive of Waldenström macroglobulinemia include:[1]
- Hypercellular and infiltrated with lymphoid and plasmacytoid cells.
- Dutcher bodies (PAS positive intranuclear vacuoles containing IgM monoclonal protein)
- Characteristic feature of Waldenström macroglobulinemia
Three patterns of marrow involvement are described, as follows:
- Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern
- Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern
- A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures)
References
- ↑ 1.0 1.1 1.2 Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J; et al. (2008). "Waldenstrom macroglobulinemia". Cancer Lett. 270 (1): 95–107. doi:10.1016/j.canlet.2008.04.040. PMC 3133633. PMID 18555588.