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==Differential Diagnosis==
==Differential Diagnosis==
{{ddx0|Legionnaires' disease}}{{ddx1|[[Acute interstitial pneumonia]]}}
* Legionnaires' disease
{{ddx1|[[Mycoplasma pneumonia]]}}
* Mycoplasma pneumonia
{{ddx1|Pneumococcal [[pneumonia]]}}
* Pneumococcal pneumonia
{{ddx1|Pneumocystis carinii [[pneumonia]]}}
* Pneumocystis carinii pneumonia
{{ddx1|[[Pulmonary embolism]]}}
* Pulmonary embolism
{{ddx1|Streptococcal [[pneumonia]]}}
* Streptococcal pneumonia
{{ddx1|Viral [[pneumonia]]}}
* Viral pneumonia


----


{{ddx|Legionnaires' disease}}
=====Clinical manifestations=====
* [[Adult respiratory distress syndrome]]
* [[Breath sounds|Bronchial breath sounds]]
* [[Dry cough]]
* [[Fever|High grade fever]]
* [[Dyspnea|Progressive dyspnea]]
=====Laboratory abnormalities=====
* Legionella urinary antigen positive
* [[Leukocytosis]] with relative [[lymphopenia]]
* [[Hyponatremia]]
* [[Hypophosphatemia]]
=====Radiographic features=====
* [[Alveoli|Alveolar consolidation]] on chest radiograph
* [[Consolidation (medicine)|Lobar consolidation]] on chest radiograph
----
{{ddx|Acute interstitial pneumonia}}
=====Clinical manifestations=====
* [[Dry cough]]
* [[Dyspnea|Progressive dyspnea]]
=====Laboratory abnormalities=====
* Nonspecific
=====Radiographic features=====
* Disseminated [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
* Interstitial infiltrate on chest radiograph
* Increased uptake on gallium scan
-----
{{ddx|Mycoplasma pneumonia}}
=====Clinical manifestations=====
* [[Dry cough]]
* [[Pleuritic chest pain]]
* Bronchial [[breath sounds]]
* [[Inflamed]], opaque, hypomobile [[tympanic membrane]]
=====Laboratory abnormalities=====
* [[Lymphocytosis]]
* [[Cold agglutinins]] positive
=====Radiographic features=====
* [[Alveolar]] [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
* Interstitial infiltrate on [[chest radiograph]]
* Lobar [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
----
{{ddx|Pneumococcal pneumonia}}
=====Clinical manifestations=====
* [[Fever|High grade fever]]
* [[Hemoptysis]]
* [[Rales|Fine rales]]
* [[Pleuritic chest pain]]
* Increased [[breath sounds]]
* Bronchial b[[Breath sounds|reath sounds]]
* Dullness on chest percussion
* [[Sputum|Purulent sputum]]
* [[Shallow respiration]]
* Pectoriloquy
* Increased [[tactile fremitus]]
* [[Productive cough]]
* [[Egophony]]
=====Laboratory abnormalities=====
* [[Gram positive bacteria|Gram positive]] [[diplococci]] on sputum Gram stain
* [[Pleural effusion]] ([[exudative]])
* Respiratory alkalosis
=====Radiographic features=====
* Parenchymal hyperlucency on [[chest radiograph]]
* Increased uptake on [[gallium scan]]
* Unilateral diaphragm elevation on [[chest radiograph]]
* Alveolar [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
* Lobar [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
----
{{ddx|Pneumocystis carinii pneumonia}}
=====Clinical manifestations=====
* [[Immunosuppressive]] state
* [[Subcutaneous emphysema]]
* [[Cough|Hacking cough]]
* [[Dyspnea|Progressive dyspnea]]
=====Laboratory abnormalities=====
* [[Respiratory alkalosis]]
* Serum beta-D-glucan elevation
=====Radiographic features=====
* [[Alveolar]] [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
* Lobar [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
* Interstitial infiltrate on [[chest radiograph]]
* [[Pneumomediastinum]] on [[chest radiograph]]
----
{{ddx|Pulmonary embolism}}
=====Clinical manifestations=====
* Calf [[pain]] or [[swelling]]
* Decreased [[pulse pressure]]
* [[Dyspnea]]
* [[Hemoptysis]]
* [[Hyperventilation]]
* [[Immobility]]
* Increased pulmonic component of heart sound
* [[Pleuritic chest pain]]
* Prior [[Deep vein thrombosis|DVT]]
* [[Pulmonary hypertension]]
* Right ventricular heave
* [[Right-to-left shunt]]
* [[Substernal chest pain]]
* [[Tachypnea]]
* [[Thrombophlebitis]]
* [[Venous stasis]]
* [[Bone fracture]]
=====Laboratory abnormalities=====
* [[D-dimer]] elevation
* [[Hypocapnia]]
* [[Hypoxia]]
* [[Pleural effusion]] (exudative or bloody)
* [[Atrial fibrillation]] on ECG
* [[Right axis deviation]] on ECG
* Right ventricular overload on ECG
=====Radiographic features=====
* Normal [[chest radiograph]]
* [[Atelectasis]] on [[chest radiograph]]
* Lobar consolidation on [[chest radiograph]]
* Prominent [[pulmonary artery]] on [[chest radiograph]]
* [[Hampton's hump]] on [[chest radiograph]]
* Right ventricular enlargement on [[echocardiography]]
* [[Thrombus]] on echocardiography
* Segmental [[perfusion]] defect on lung scan
* [[V/Q scan|V/Q]] mismatch on lung scan
----
{{ddx|Streptococcal pneumonia}}
=====Clinical manifestations=====
* Pectoriloquy
* Bronchial [[breath sounds]]
* [[Erythema nodosum]]
* Purulent [[sputum]]
* [[Shallow respiration]]
* Increased [[tactile fremitus]]
* [[Pleuritic chest pain]]
* [[Egophony]]
=====Laboratory abnormalities=====
* [[Gram-positive cocci]] in chains on sputum [[Gram stain]]
* [[Respiratory alkalosis]]
* [[Pleural effusion]] (exudative)
=====Radiographic features=====
* Alveolar consolidation on chest radiograph
* Lobar consolidation on chest radiograph
* [[Empyema]] on chest radiograph
* Increased uptake on [[gallium scan]]
----
{{ddx|Viral pneumonia}}
=====Clinical manifestations=====
* [[Pleuritic chest pain]]
* [[Breath sounds|Bronchial breath sounds]]
* Recent [[influenza]]
* Fine [[rales]]
* [[Breath sounds|Bronchovesicular breath sounds]]
=====Laboratory abnormalities=====
* [[Lymphocytosis]]
* [[Respiratory alkalosis]]
=====Radiographic features=====
* Lobar [[Consolidation (medicine)|consolidation]] on [[chest radiograph]]
* Interstitial infiltrate on [[chest radiograph]]


==Differentiating legionellosis from other causes of atypical pneumonia==
==Differentiating legionellosis from other causes of atypical pneumonia==

Revision as of 17:52, 2 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Legionellosis must be differentiated from other causes of fever, dyspnea, cough, and sputum production, such as bacterial pneumonia, viral pneumonia, and other causes of atypical pneumonia.

Differential Diagnosis

  • Legionnaires' disease
  • Mycoplasma pneumonia
  • Pneumococcal pneumonia
  • Pneumocystis carinii pneumonia
  • Pulmonary embolism
  • Streptococcal pneumonia
  • Viral pneumonia


Differentiating legionellosis from other causes of atypical pneumonia

Legionellosis must be differentiated from other diseases that cause atypical pneumonia such as Q fever and mycoplasma pneumonia

Disease Prominent clinical features Lab findings Chest X-ray
Q fever
  • Antibody detection using indirect immunofluorescence (IIF) is the preferred method for diagnosis.
  • PCR can be used if IIF is negative, or very early once disease is suspected.
  • C. burnetii does not grow on ordinary blood cultures, but can be cultivated on special media such as embryonated eggs or cell culture.
  • A two-to-three fold increase in AST and ALT is seen in most patients.
Q fever pneumonia - - Case courtesy of Royal Melbourne Hospital Respiratory, Radiopaedia.org, rID 21993
Mycoplasma pneumonia
Mycoplasma pneumonia - Case courtesy of Dr Alborz Jahangiri, Radiopaedia.org, rID 45781
Legionellosis
Legionella pneumonia - Case courtesy of Dr Henry Knipe, Radiopaedia.org, rID 31816
Chlamydia pneumonia
Chlamydia-pneumonia - Case courtesy of Dr Andrew Dixon, Radiopaedia.org, rID 14567

References

  1. 1.0 1.1 1.2 1.3 Irfan M, Farooqi J, Hasan R (2013). "Community-acquired pneumonia". Curr Opin Pulm Med. 19 (3): 198–208. doi:10.1097/MCP.0b013e32835f1d12. PMID 23422417.