Multiple myeloma diagnostic criteria: Difference between revisions
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===Revised Criteria for the Diagnosis of Multiple Myeloma=== | ===Revised Criteria for the Diagnosis of Multiple Myeloma=== | ||
The diagnosis of multiple myeloma requires the following:<ref name="lancet">Rajkumar, S. Vincent, Meletios A. Dimopoulos, Antonio Palumbo, Joan Blade, Giampaolo Merlini, María-Victoria Mateos, Shaji Kumar et al. "International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma." The Lancet Oncology 15, no. 12 (2014): e538-e548</ref> | The [[diagnosis]] of [[multiple myeloma]] requires the following:<ref name="lancet">Rajkumar, S. Vincent, Meletios A. Dimopoulos, Antonio Palumbo, Joan Blade, Giampaolo Merlini, María-Victoria Mateos, Shaji Kumar et al. "International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma." The Lancet Oncology 15, no. 12 (2014): e538-e548</ref> | ||
*≥10% clonal plasma cells in bone marrow | *≥10% clonal [[plasma cells]] in [[bone marrow]] | ||
'''OR''' | '''OR''' | ||
*biopsy-proven bony or extramedullary plasmacytoma, | *[[biopsy]]-proven bony or [[Plasmacytoma|extramedullary plasmacytoma]], | ||
'''With''' one or more of the CRAB features and myeloma-defining events: | '''With''' one or more of the CRAB features and [[Multiple myeloma|myeloma]]-defining events: | ||
*CRAB features: | *CRAB features: | ||
**'''Hypercalcemia''': serum calcium >0·25 mmol/L (>1 mg/dL) higher than the upper limit of normal or >2·75 mmol/L (>11 mg/dL) | **'''[[Hypercalcemia]]''': [[Calcium|serum calcium]] >0·25 mmol/L (>1 mg/dL) higher than the upper limit of normal or >2·75 mmol/L (>11 mg/dL) | ||
**'''Renal insufficiency''': creatinine clearance <40 mL per min or serum creatinine >177 μmol/L (>2 mg/dL) | **'''[[Renal insufficiency]]''': [[creatinine]] clearance <40 mL per min or [[serum creatinine]] >177 μmol/L (>2 mg/dL) | ||
**'''Anemia''': hemoglobin value of >2 g/dL below the lower limit of normal, or a hemoglobin value <10 g/dL | **'''[[Anemia]]''': [[hemoglobin]] value of >2 g/dL below the lower limit of normal, or a [[hemoglobin]] value <10 g/dL | ||
**'''Bone lesion''': one or more osteolytic lesions on skeletal radiography, CT, or PET-CT | **'''[[Bone]] [[lesion]]''': one or more osteolytic [[lesions]] on [[Skeleton|skeletal]] [[radiography]], [[CT-scans|CT]], or [[PET scan|PET-CT]] | ||
*Myeloma-defining events: | *Myeloma-defining events: | ||
**'''Bone marrow plasma cell burden''': Clonal bone marrow plasma cell percentage ≥60% | **'''[[Bone marrow]] [[plasma cell]] burden''': Clonal [[bone marrow]] [[plasma cell]] percentage ≥60% | ||
**'''Free light chain ratio''': Involved-to-uninvolved free light chain ratio ≥100 | **'''[[Light chain|Free light chain]] ratio''': Involved-to-uninvolved free [[light chain]] ratio ≥100 | ||
**'''MRI''': >1 focal bony lesion of 5mm or greater on MRI studies | **'''[[MRI]]''': >1 focal [[Bone|bony]] [[lesion]] of 5mm or greater on [[MRI]] studies | ||
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*≥10% clonal plasma cells in bone marrow | *≥10% clonal [[plasma cells]] in [[bone marrow]] | ||
'''OR''' | '''OR''' | ||
*biopsy-proven bony or extramedullary plasmacytoma | *biopsy-proven bony or [[Plasmacytoma|extramedullary plasmacytoma]] | ||
'''With''' one or more of the following: | '''With''' one or more of the following: | ||
*'''Hypercalcemia''': serum calcium >0·25 mmol/L (>1 mg/dL) higher than the upper limit of normal or >2·75 mmol/L (>11 mg/dL) | * '''[[Hypercalcemia]]''': [[Calcium|serum calcium]] >0·25 mmol/L (>1 mg/dL) higher than the upper limit of normal or >2·75 mmol/L (>11 mg/dL) | ||
*'''Renal insufficiency''': creatinine clearance <40 mL per min or serum creatinine >177 μmol/L (>2 mg/dL) | |||
*'''Anemia''': hemoglobin value of >2 g/dL below the lower limit of normal, or a hemoglobin value <10 g/dL | *'''[[Renal insufficiency]]''': [[creatinine]] clearance <40 mL per min or [[serum creatinine]] >177 μmol/L (>2 mg/dL) | ||
*'''Bone lesion''': one or more osteolytic lesions on skeletal radiography, CT, or PET-CT | *'''[[Anemia]]''': [[hemoglobin]] value of >2 g/dL below the lower limit of normal, or a [[hemoglobin]] value <10 g/dL | ||
*'''Bone marrow plasma cell burden''': Clonal bone marrow plasma cell percentage ≥60% | *'''[[Bone]] [[lesion]]''': one or more osteolytic [[lesions]] on [[Skeleton|skeletal]] [[radiography]], [[CT-scans|CT]], or [[PET scan|PET-CT]] | ||
*'''Free light chain ratio''': Involved-to-uninvolved free light chain ratio ≥100 | |||
*'''MRI''': >1 focal bony lesion of 5mm or greater on MRI studies | *'''[[Bone marrow]] [[plasma cell]] burden''': Clonal [[bone marrow]] [[plasma cell]] percentage ≥60% | ||
*'''[[Light chain|Free light chain]] ratio''': Involved-to-uninvolved free [[light chain]] ratio ≥100 | |||
*'''[[MRI]]''': >1 focal [[Bone|bony]] [[lesion]] of 5mm or greater on [[MRI]] studies | |||
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Revision as of 14:58, 7 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2] Associate Editor(s)-in-Chief: Serge Korjian M.D. Shyam Patel [3]
Overview
The diagnosis of monoclonal gammopathy of undetermined significance requires the presence of clonal plasma cells < 10% and serum monoclonal protein <3g/dl but the absence of end-organ damage. The diagnosis of smoldering multiple myeloma requires the presence of clonal plasma cells 10%-60% and serum monoclonal protein >3g/dl but the absence of end-organ damage. The diagnosis of active multiple myeloma requires the presence of end-organ damage. In November 2014, the International Myeloma Working Group (IMWG) updated the criteria for the diagnosis of multiple myeloma to include novel validated biomarkers to better encompass the extent of disease. Prior to 2014, the original diagnostic criteria for end-organ damage included CRAB features (hypercalcemia, renal failure, anemia, and bone lesions) without consideration of the plasma cell burden or free light chain ratio. The 2014 update also clarified the underlying laboratory and radiographic findings of CRAB features, as well as the histological and monoclonal protein requirements for the disease diagnosis.[1]
Diagnostic Criteria
Revised Criteria for the Diagnosis of Multiple Myeloma
The diagnosis of multiple myeloma requires the following:[1]
- ≥10% clonal plasma cells in bone marrow
OR
- biopsy-proven bony or extramedullary plasmacytoma,
With one or more of the CRAB features and myeloma-defining events:
- CRAB features:
- Hypercalcemia: serum calcium >0·25 mmol/L (>1 mg/dL) higher than the upper limit of normal or >2·75 mmol/L (>11 mg/dL)
- Renal insufficiency: creatinine clearance <40 mL per min or serum creatinine >177 μmol/L (>2 mg/dL)
- Anemia: hemoglobin value of >2 g/dL below the lower limit of normal, or a hemoglobin value <10 g/dL
- Bone lesion: one or more osteolytic lesions on skeletal radiography, CT, or PET-CT
- Myeloma-defining events:
- Bone marrow plasma cell burden: Clonal bone marrow plasma cell percentage ≥60%
- Free light chain ratio: Involved-to-uninvolved free light chain ratio ≥100
- MRI: >1 focal bony lesion of 5mm or greater on MRI studies
| Revised Criteria for the Diagnosis of Multiple Myeloma |
|---|
OR
With one or more of the following:
|
Criteria for the Diagnosis of Monoclonal Gammopathy of Undetermined Significance (MGUS)
All three criteria must be met:
- Presence of serum monoclonal protein (IgG or IgA) <3 g/dL
- Presence of bone marrow clonal plasma cells <10%
- Absence of multiple myeloma-defining events or amyloidosis
Criteria for the Diagnosis of Smoldering Multiple Myeloma
Both criteria must be met[1]:
- Serum monoclonal protein (IgG or IgA) ≥3 g/dL or urinary monoclonal protein ≥500 mg per 24 h and/or clonal bone marrow plasma cells 10–60%
- Absence of multiple myeloma-defining events or amyloidosis
Revised Criteria for the Diagnosis of Multiple Myeloma
Both criteria must be met:[1]
- ≥10% clonal expansion of bone marrow plasma cells or biopsy-proven bony or extramedullary plasmacytoma, and one or more of the following 7 features:
- Evidence of end organ damage that can be attributed to the underlying plasma cell proliferative disorder:
- Hypercalcemia: serum calcium >0·25 mmol/L (>1 mg/dL) higher than the upper limit of normal or >2·75 mmol/L (>11 mg/dL)
- Renal insufficiency: creatinine clearance <40 mL per min or serum creatinine >177 μmol/L (>2 mg/dL)
- Anemia: hemoglobin value of >2 g/dL below the lower limit of normal, or a hemoglobin value <10 g/dL
- Bone lesion: one or more osteolytic lesions on skeletal radiography, CT, or PET-CT
- Bone marrow plasma cell burden: Clonal bone marrow plasma cell percentage ≥60%
- Free light chain ratio: Involved-to-uninvolved free light chain ratio ≥100
- MRI: >1 focal bony lesion of 5mm or greater on MRI studies