Adult T-cell leukemia future or investigational therapies: Difference between revisions
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{{Adult T-cell leukemia}} | {{Adult T-cell leukemia}} | ||
Molecular targeting therapy like targeting therapy against ''NOTCH1''/''FBXW7'' mutations, JAK-STAT signaling pathway and inhibition of the PI3K-signaling pathway are the future investigation therapy for adult t-cell leukemia.<ref name="pmid25193870">{{cite journal |vauthors=Degryse S, de Bock CE, Cox L, Demeyer S, Gielen O, Mentens N, Jacobs K, Geerdens E, Gianfelici V, Hulselmans G, Fiers M, Aerts S, Meijerink JP, Tousseyn T, Cools J |title=JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model |journal=Blood |volume=124 |issue=20 |pages=3092–100 |date=November 2014 |pmid=25193870 |doi=10.1182/blood-2014-04-566687 |url=}}</ref> | Molecular targeting therapy like targeting therapy against ''NOTCH1''/''FBXW7'' mutations, JAK-STAT signaling pathway and inhibition of the PI3K-signaling pathway are the future investigation therapy for adult t-cell leukemia.<ref name="pmid25193870">{{cite journal |vauthors=Degryse S, de Bock CE, Cox L, Demeyer S, Gielen O, Mentens N, Jacobs K, Geerdens E, Gianfelici V, Hulselmans G, Fiers M, Aerts S, Meijerink JP, Tousseyn T, Cools J |title=JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model |journal=Blood |volume=124 |issue=20 |pages=3092–100 |date=November 2014 |pmid=25193870 |doi=10.1182/blood-2014-04-566687 |url=}}</ref><ref name="pmid22516257">{{cite journal |vauthors=Subramaniam PS, Whye DW, Efimenko E, Chen J, Tosello V, De Keersmaecker K, Kashishian A, Thompson MA, Castillo M, Cordon-Cardo C, Davé UP, Ferrando A, Lannutti BJ, Diacovo TG |title=Targeting nonclassical oncogenes for therapy in T-ALL |journal=Cancer Cell |volume=21 |issue=4 |pages=459–72 |date=April 2012 |pmid=22516257 |doi=10.1016/j.ccr.2012.02.029 |url=}}</ref> | ||
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Molecular targeting therapy like targeting therapy against NOTCH1/FBXW7 mutations, JAK-STAT signaling pathway and inhibition of the PI3K-signaling pathway are the future investigation therapy for adult t-cell leukemia.[1][2]
- ↑ Degryse S, de Bock CE, Cox L, Demeyer S, Gielen O, Mentens N, Jacobs K, Geerdens E, Gianfelici V, Hulselmans G, Fiers M, Aerts S, Meijerink JP, Tousseyn T, Cools J (November 2014). "JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model". Blood. 124 (20): 3092–100. doi:10.1182/blood-2014-04-566687. PMID 25193870.
- ↑ Subramaniam PS, Whye DW, Efimenko E, Chen J, Tosello V, De Keersmaecker K, Kashishian A, Thompson MA, Castillo M, Cordon-Cardo C, Davé UP, Ferrando A, Lannutti BJ, Diacovo TG (April 2012). "Targeting nonclassical oncogenes for therapy in T-ALL". Cancer Cell. 21 (4): 459–72. doi:10.1016/j.ccr.2012.02.029. PMID 22516257.