Lymphomatoid granulomatosis causes: Difference between revisions
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It is likely that some amalgamation of immunodeficiency, genetic and familial factors all contribute a role in the causation of lymphomatoid granulomatosis. The therapy used varies, but is generally directed towards eliminating the EBV-infected B-cells or strengthening of the immune system.<ref name="pmid9547995">{{cite journal| author=Jaffe ES, Wilson WH| title=Lymphomatoid granulomatosis: pathogenesis, pathology and clinical implications. | journal=Cancer Surv | year= 1997 | volume= 30 | issue= | pages= 233-48 | pmid=9547995 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9547995 }} </ref><ref name="pmid29676363">{{cite journal| author=Sigamani E, Chandramohan J, Nair S, Chacko G, Thomas M, Mathew LG et al.| title=Lymphomatoid granulomatosis: A case series from South India. | journal=Indian J Pathol Microbiol | year= 2018 | volume= 61 | issue= 2 | pages= 228-232 | pmid=29676363 | doi=10.4103/IJPM.IJPM_471_17 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29676363 }} </ref> | It is likely that some amalgamation of immunodeficiency, genetic and familial factors all contribute a role in the causation of lymphomatoid granulomatosis. The therapy used varies, but is generally directed towards eliminating the EBV-infected B-cells or strengthening of the immune system.<ref name="pmid9547995">{{cite journal| author=Jaffe ES, Wilson WH| title=Lymphomatoid granulomatosis: pathogenesis, pathology and clinical implications. | journal=Cancer Surv | year= 1997 | volume= 30 | issue= | pages= 233-48 | pmid=9547995 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9547995 }} </ref><ref name="pmid29676363">{{cite journal| author=Sigamani E, Chandramohan J, Nair S, Chacko G, Thomas M, Mathew LG et al.| title=Lymphomatoid granulomatosis: A case series from South India. | journal=Indian J Pathol Microbiol | year= 2018 | volume= 61 | issue= 2 | pages= 228-232 | pmid=29676363 | doi=10.4103/IJPM.IJPM_471_17 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29676363 }} </ref> | ||
==Causes== | ==Causes== | ||
===Common Causes=== | ===Common Causes=== | ||
Lymphomatoid granulomatosis involves malignant B cells and reactive, non-malignant T cells and is almost always associated with infection of the malignant B cells by the Epstein-Barr virus; it is therefore known to be a form of the Epstein-Barr virus-associated lymphoproliferative diseases. The disease is believed to be induced by a combination of Epstein Barr virus infection and immunosuppression through immunosuppressive drugs (with case reports of methotrexate and azathioprine), infections such as HIV or chronic viral hepatitis or endogenous T cell defects.<ref name="pmid29885408">{{cite journal| author=Rezk SA, Zhao X, Weiss LM| title=Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update. | journal=Hum Pathol | year= 2018 | volume= 79 | issue= | pages= 18-41 | pmid=29885408 | doi=10.1016/j.humpath.2018.05.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29885408 }} </ref><ref name="pmid25130128">{{cite journal| author=Oiwa H, Mihara K, Kan T, Tanaka M, Shindo H, Kumagai K et al.| title=Grade 3 lymphomatoid granulomatosis in a patient receiving methotrexate therapy for rheumatoid arthritis. | journal=Intern Med | year= 2014 | volume= 53 | issue= 16 | pages= 1873-5 | pmid=25130128 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25130128 }} </ref><ref name="pmid25674479">{{cite journal| author=Barakat A, Grover K, Peshin R| title=Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis. | journal=Springerplus | year= 2014 | volume= 3 | issue= | pages= 751 | pmid=25674479 | doi=10.1186/2193-1801-3-751 | pmc=4320142 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25674479 }} </ref><ref name="pmid17200802">{{cite journal| author=Kameda H, Okuyama A, Tamaru J, Itoyama S, Iizuka A, Takeuchi T| title=Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis. | journal=Clin Rheumatol | year= 2007 | volume= 26 | issue= 9 | pages= 1585-9 | pmid=17200802 | doi=10.1007/s10067-006-0480-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17200802 }} </ref>===Causes by Organ System=== | Lymphomatoid granulomatosis involves malignant B cells and reactive, non-malignant T cells and is almost always associated with infection of the malignant B cells by the Epstein-Barr virus; it is therefore known to be a form of the Epstein-Barr virus-associated lymphoproliferative diseases. The disease is believed to be induced by a combination of Epstein Barr virus infection and immunosuppression through immunosuppressive drugs (with case reports of methotrexate and azathioprine), infections such as HIV or chronic viral hepatitis or endogenous T cell defects.<ref name="pmid29885408">{{cite journal| author=Rezk SA, Zhao X, Weiss LM| title=Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update. | journal=Hum Pathol | year= 2018 | volume= 79 | issue= | pages= 18-41 | pmid=29885408 | doi=10.1016/j.humpath.2018.05.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29885408 }} </ref><ref name="pmid25130128">{{cite journal| author=Oiwa H, Mihara K, Kan T, Tanaka M, Shindo H, Kumagai K et al.| title=Grade 3 lymphomatoid granulomatosis in a patient receiving methotrexate therapy for rheumatoid arthritis. | journal=Intern Med | year= 2014 | volume= 53 | issue= 16 | pages= 1873-5 | pmid=25130128 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25130128 }} </ref><ref name="pmid25674479">{{cite journal| author=Barakat A, Grover K, Peshin R| title=Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis. | journal=Springerplus | year= 2014 | volume= 3 | issue= | pages= 751 | pmid=25674479 | doi=10.1186/2193-1801-3-751 | pmc=4320142 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25674479 }} </ref><ref name="pmid17200802">{{cite journal| author=Kameda H, Okuyama A, Tamaru J, Itoyama S, Iizuka A, Takeuchi T| title=Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis. | journal=Clin Rheumatol | year= 2007 | volume= 26 | issue= 9 | pages= 1585-9 | pmid=17200802 | doi=10.1007/s10067-006-0480-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17200802 }} </ref> | ||
===Causes by Organ System=== | |||
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Revision as of 15:51, 28 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The exact cause of lymphomatoid granulomatosis is unknown. Lymphomatoid granulomatosis occurs with more in people with some form of immune system dysability including individuals with Sjogren syndrome, rheumatoid arthritis or chronic viral hepatitis.
It is likely that some amalgamation of immunodeficiency, genetic and familial factors all contribute a role in the causation of lymphomatoid granulomatosis. The therapy used varies, but is generally directed towards eliminating the EBV-infected B-cells or strengthening of the immune system.[1][2]
Causes
Common Causes
Lymphomatoid granulomatosis involves malignant B cells and reactive, non-malignant T cells and is almost always associated with infection of the malignant B cells by the Epstein-Barr virus; it is therefore known to be a form of the Epstein-Barr virus-associated lymphoproliferative diseases. The disease is believed to be induced by a combination of Epstein Barr virus infection and immunosuppression through immunosuppressive drugs (with case reports of methotrexate and azathioprine), infections such as HIV or chronic viral hepatitis or endogenous T cell defects.[3][4][5][6]
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order:
- Cause 1
- Cause 2
- Cause 3
- Cause 4
- Cause 5
- Cause 6
- Cause 7
- Cause 8
- Cause 9
- Cause 10
References
- ↑ Jaffe ES, Wilson WH (1997). "Lymphomatoid granulomatosis: pathogenesis, pathology and clinical implications". Cancer Surv. 30: 233–48. PMID 9547995.
- ↑ Sigamani E, Chandramohan J, Nair S, Chacko G, Thomas M, Mathew LG; et al. (2018). "Lymphomatoid granulomatosis: A case series from South India". Indian J Pathol Microbiol. 61 (2): 228–232. doi:10.4103/IJPM.IJPM_471_17. PMID 29676363.
- ↑ Rezk SA, Zhao X, Weiss LM (2018). "Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update". Hum Pathol. 79: 18–41. doi:10.1016/j.humpath.2018.05.020. PMID 29885408.
- ↑ Oiwa H, Mihara K, Kan T, Tanaka M, Shindo H, Kumagai K; et al. (2014). "Grade 3 lymphomatoid granulomatosis in a patient receiving methotrexate therapy for rheumatoid arthritis". Intern Med. 53 (16): 1873–5. PMID 25130128.
- ↑ Barakat A, Grover K, Peshin R (2014). "Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis". Springerplus. 3: 751. doi:10.1186/2193-1801-3-751. PMC 4320142. PMID 25674479.
- ↑ Kameda H, Okuyama A, Tamaru J, Itoyama S, Iizuka A, Takeuchi T (2007). "Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis". Clin Rheumatol. 26 (9): 1585–9. doi:10.1007/s10067-006-0480-2. PMID 17200802.