Hodgkin's lymphoma historical perspective: Difference between revisions
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Hodgkin's lymphoma was first discovered by [[Thomas Hodgkin]], a British physician, in 1832. | Hodgkin's lymphoma was first discovered by [[Thomas Hodgkin]], a British physician, in 1832. | ||
==Historical Perspective== | ==Historical Perspective== | ||
* Hodgkin's lymphoma was first described | * Hodgkin's lymphoma was first described by [[Thomas Hodgkin]], a British physician, in 1832.Although earliest desciption for this disease was provided by [[Marcello Malpighi]] in 1666.<ref name="Hoppe2007">{{cite book |author=Hellman S |editor=Hoppe RT, Mauch PT, Armitage JO, Diehl V, Weiss LM |title=Hodgkin Lymphoma |chapter=Brief Consideration of Thomas Hodgkin and His Times |publisher=Wolters Kluwer Health/Lippincott Williams & Wilkins |location=Philadelphia |year=2007 |edition=2nd |pages=3–6 |isbn=0-7817-6422-X |oclc= |doi= |accessdate=}}</ref><ref name="Hodgkin1832">{{cite journal |title=On some morbid experiences of the absorbent glands and spleen |author=Hodgkin T |journal=Med Chir Trans |volume=17 |pages=69–97 |year=1832}}</ref> While occupied as museum curator at [[Guy's Hospital]], Hodgkin studied seven patients with painless lymph node enlargement. Of the seven cases, two were patients of [[Richard Bright (physician)|Richard Bright]], one was of [[Thomas Addison]], and one was of Robert Carswell.<ref name="Hoppe2007" /> Carswell's report of this seventh patient was accompanied by numerous illustrations that aided early descriptions of the disease.<ref name="pmid10594291">{{cite journal | author = Dawson PJ | title = The original illustrations of Hodgkin's disease | journal = Annals of Diagnostic Pathology | volume = 3 | issue = 6 | pages = 386–93 | date = December 1999 | pmid = 10594291 | doi = 10.1053/ADPA00300386 | url = http://linkinghub.elsevier.com/retrieve/pii/00300386 | doi_brokendate = 2015-01-01 }}</ref> | ||
* Hodgkin's report on these seven patients, entitled "On some morbid appearances of the absorbent glands and spleen", was presented to the Medical and Chirurgical Society in London in January 1832 and was subsequently published in the society's journal, ''Medical-Chirurgical Society Transactions''.<ref name="Hoppe2007" /> Hodgkin's paper went largely unnoticed, however, even despite Bright highlighting it in an 1838 publication.<ref name="Hoppe2007" /> Indeed, Hodgkin himself did not view his contribution as particularly significant.<ref name="Geller1984">{{cite journal | author = Geller SA | title = Comments on the anniversary of the description of Hodgkin's disease | journal = Journal of the National Medical Association | volume = 76 | issue = 8 | pages = 815–7 | date = August 1984 | pmid = 6381744 | pmc = 2609834 | doi = | url = }}</ref> | * Hodgkin's report on these seven patients, entitled "On some morbid appearances of the absorbent glands and spleen", was presented to the Medical and Chirurgical Society in London in January 1832 and was subsequently published in the society's journal, ''Medical-Chirurgical Society Transactions''.<ref name="Hoppe2007" /> Hodgkin's paper went largely unnoticed, however, even despite Bright highlighting it in an 1838 publication.<ref name="Hoppe2007" /> Indeed, Hodgkin himself did not view his contribution as particularly significant.<ref name="Geller1984">{{cite journal | author = Geller SA | title = Comments on the anniversary of the description of Hodgkin's disease | journal = Journal of the National Medical Association | volume = 76 | issue = 8 | pages = 815–7 | date = August 1984 | pmid = 6381744 | pmc = 2609834 | doi = | url = }}</ref> | ||
* In 1856, [[Samuel Wilks]] independently reported on a series of patients with the same disease that Hodgkin had previously described.<ref name="Geller1984" /> Wilks, a successor to Hodgkin at Guy's Hospital, was unaware of Hodgkin's prior work on the subject. Bright made Wilks aware of Hodgkin's contribution and in 1865, Wilks published a second paper, entitled "Cases of enlargement of the lymphatic glands and spleen", in which he called the disease "Hodgkin's disease" in honor of his predecessor.<ref name="Geller1984" /> | * In 1856, [[Samuel Wilks]] independently reported on a series of patients with the same disease that Hodgkin had previously described.<ref name="Geller1984" /> Wilks, a successor to Hodgkin at Guy's Hospital, was unaware of Hodgkin's prior work on the subject. Bright made Wilks aware of Hodgkin's contribution and in 1865, Wilks published a second paper, entitled "Cases of enlargement of the lymphatic glands and spleen", in which he called the disease "Hodgkin's disease" in honor of his predecessor.<ref name="Geller1984" /> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Hodgkin's lymphoma was first discovered by Thomas Hodgkin, a British physician, in 1832.
Historical Perspective
- Hodgkin's lymphoma was first described by Thomas Hodgkin, a British physician, in 1832.Although earliest desciption for this disease was provided by Marcello Malpighi in 1666.[1][2] While occupied as museum curator at Guy's Hospital, Hodgkin studied seven patients with painless lymph node enlargement. Of the seven cases, two were patients of Richard Bright, one was of Thomas Addison, and one was of Robert Carswell.[1] Carswell's report of this seventh patient was accompanied by numerous illustrations that aided early descriptions of the disease.[3]
- Hodgkin's report on these seven patients, entitled "On some morbid appearances of the absorbent glands and spleen", was presented to the Medical and Chirurgical Society in London in January 1832 and was subsequently published in the society's journal, Medical-Chirurgical Society Transactions.[1] Hodgkin's paper went largely unnoticed, however, even despite Bright highlighting it in an 1838 publication.[1] Indeed, Hodgkin himself did not view his contribution as particularly significant.[4]
- In 1856, Samuel Wilks independently reported on a series of patients with the same disease that Hodgkin had previously described.[4] Wilks, a successor to Hodgkin at Guy's Hospital, was unaware of Hodgkin's prior work on the subject. Bright made Wilks aware of Hodgkin's contribution and in 1865, Wilks published a second paper, entitled "Cases of enlargement of the lymphatic glands and spleen", in which he called the disease "Hodgkin's disease" in honor of his predecessor.[4]
- Theodor Langhans and WS Greenfield first described the microscopic characteristics of Hodgkin's lymphoma in 1872 and 1878, respectively.[1]
- In 1898 and 1902, respectively, Carl Sternberg, and Dorothy Reed independently described the cytogenetic features of the malignant cells of Hodgkin's lymphoma, now called Reed–Sternberg cells.[1]
- Tissue specimens from Hodgkin's seven patients remained at Guy's Hospital for a number of years. Nearly 100 years after Hodgkin's initial publication, histopathologic reexamination confirmed Hodgkin's lymphoma in only three of seven of these patients.[4] The remaining cases included non-Hodgkin lymphoma, tuberculosis, and syphilis.[4]
- Hodgkin's lymphoma was one of the first cancers which could be treated using radiation therapy and, later, it was one of the first to be treated by combination chemotherapy.
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Photograph from a 1938 medical textbook labeled "Hodgkin's Disease".
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Hellman S (2007). "Brief Consideration of Thomas Hodgkin and His Times". In Hoppe RT, Mauch PT, Armitage JO, Diehl V, Weiss LM. Hodgkin Lymphoma (2nd ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. pp. 3–6. ISBN 0-7817-6422-X.
- ↑ Hodgkin T (1832). "On some morbid experiences of the absorbent glands and spleen". Med Chir Trans. 17: 69–97.
- ↑ Dawson PJ (December 1999). "The original illustrations of Hodgkin's disease". Annals of Diagnostic Pathology. 3 (6): 386–93. doi:10.1053/ADPA00300386. PMID 10594291. Unknown parameter
|doi_brokendate=ignored (help) - ↑ 4.0 4.1 4.2 4.3 4.4 Geller SA (August 1984). "Comments on the anniversary of the description of Hodgkin's disease". Journal of the National Medical Association. 76 (8): 815–7. PMC 2609834. PMID 6381744.