Polycythemia vera history and symptoms: Difference between revisions

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==Overview==
==Overview==
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]]. The symptomatology is highly variable between patients. Some patients can present with a minimal symptom burden that does not result in any change in quality of life, and other patients can have severe symptom burden.
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]]. The symptomatology is highly variable between patients. Some patients can present with a minimal symptom burden that does not result in any change in quality of life, and other patients can have severe symptom burden.
==History and Symptoms==
Symptoms of polycythemia vera are related to the consequences of excess [[red blood cells]]. These symptoms may include:
*[[Headache]]
*[[Pruritis]]
:*Especially after exposure to warm water
:*Due to [[histamine]] release or [[prostaglandin]] production
:*Present in approximately 40% of patients
*[[Tinnitis]]
*[[Blurred vision]]
*[[Malaise]]
*[[Loss of appetite]]
*[[Weight loss]]
*[[Shortness of breath]]
*[[Fatigue]]
*[[Dizziness]]
*[[Bleeding]]
:*[[Bruising]]
:*[[Epistaxis]]
:*[[Bleeding gums]]
:*[[Menorrhagia]]
:*[[Metrorrhagia]]
:*[[Petechiae]]
*[[Chest pain]]
*[[Arthralgia]]
*[[Erythromelalgia]]
*[[Heart burn]]
:* Due to increased susceptibility to infection with [[Helicobacter pylori|H. pylori]]


==History and Symptoms==
==History and Symptoms==

Revision as of 15:18, 10 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]; Shyam Patel [3]

Overview

People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include headache, fatigue, and pruritis. The symptomatology is highly variable between patients. Some patients can present with a minimal symptom burden that does not result in any change in quality of life, and other patients can have severe symptom burden.

History and Symptoms

  • The majority of patients with [disease name] are asymptomatic.

OR

  • The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
  • Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

History

Patients with [disease name]] may have a positive history of:

  • [History finding 1]
  • [History finding 2]
  • [History finding 3]

Common Symptoms

Common symptoms of polycythemia vera include:[1]

  • Fatigue
  • Headache
  • Pruritus
    • Especially after exposure to warm water
    • May be related to serotonin release by platelets as well as elevated histamine levels
  • Abdominal pain
  • Loss of concentration
  • Night sweats
  • Sexual problems
  • Insomnia
  • Decreased mood
  • Numbness
  • Early satiety
  • Dizziness
  • Cough
  • Bone pains
  • Erythromelalgia
  • Weakness

Less Common Symptoms

Less common symptoms of polycythemia vera include[1]

  • Fever
  • Weight loss
  • Sweating
  • Visual disturbances
  • Parasthesias
  • Dyspnea

References

  1. 1.0 1.1 Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R (November 2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J. Clin. Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.

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