Hereditary spherocytosis physical examination: Difference between revisions
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{{Hereditary spherocytosis}} | {{Hereditary spherocytosis}} | ||
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==Physical Examination== | ==Physical Examination== | ||
* The [[physical examination]] findings in [[hereditary spherocytosis]] include | * The [[physical examination]] findings in [[hereditary spherocytosis]] include:<ref name="PerrottaGallagher2008">{{cite journal|last1=Perrotta|first1=Silverio|last2=Gallagher|first2=Patrick G|last3=Mohandas|first3=Narla|title=Hereditary spherocytosis|journal=The Lancet|volume=372|issue=9647|year=2008|pages=1411–1426|issn=01406736|doi=10.1016/S0140-6736(08)61588-3}}</ref> | ||
** [[Sclera|scleral]] [[icterus]] | ** [[Sclera|scleral]] [[icterus]] | ||
** [[jaundice]] | ** [[jaundice]] | ||
** [[splenomegaly]] | ** [[splenomegaly]] | ||
* [[Palpation|Palpable]] [[Spleen|spleens]] have been detected in more than 75% of affected subjects. The [[liver]] is normal in size and [[Function (biology)|function]]. | * [[Palpation|Palpable]] [[Spleen|spleens]] have been detected in more than 75% of affected subjects. The [[liver]] is normal in size and [[Function (biology)|function]]. | ||
* | * Another important clue is [[Right upper quadrant abdominal pain resident survival guide|right upper quadrant abdominal pain]] indicative of [[gallbladder disease]]. This is especially important if the [[patient]] has a [[family history]] of [[Gallbladder disease|gallbladder disease.]] | ||
* Any [[patient]] who presents with profound and sudden [[anemia]] and [[reticulocytopenia]] with the aforementioned [[Physical examination|physical findings]] also should have [[Hereditary spherocytosis|hereditary spherocytosis]] in the [[differential diagnosis]].<ref name="pmid15287938">{{cite journal| author=Bolton-Maggs PH, Stevens RF, Dodd NJ, Lamont G, Tittensor P, King MJ et al.| title=Guidelines for the diagnosis and management of hereditary spherocytosis. | journal=Br J Haematol | year= 2004 | volume= 126 | issue= 4 | pages= 455-74 | pmid=15287938 | doi=10.1111/j.1365-2141.2004.05052.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15287938 }}</ref> | * Any [[patient]] who presents with profound and sudden [[anemia]] and [[reticulocytopenia]] with the aforementioned [[Physical examination|physical findings]] also should have [[Hereditary spherocytosis|hereditary spherocytosis]] in the [[differential diagnosis]].<ref name="pmid15287938">{{cite journal| author=Bolton-Maggs PH, Stevens RF, Dodd NJ, Lamont G, Tittensor P, King MJ et al.| title=Guidelines for the diagnosis and management of hereditary spherocytosis. | journal=Br J Haematol | year= 2004 | volume= 126 | issue= 4 | pages= 455-74 | pmid=15287938 | doi=10.1111/j.1365-2141.2004.05052.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15287938 }}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief:
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Overview
The physical examination findings in hereditary spherocytosis include; scleral icterus, jaundice, splenomegaly. Right upper quadrant abdominal pain may be elicited if gallbladder disease is present.
Physical Examination
- The physical examination findings in hereditary spherocytosis include:[1]
- Palpable spleens have been detected in more than 75% of affected subjects. The liver is normal in size and function.
- Another important clue is right upper quadrant abdominal pain indicative of gallbladder disease. This is especially important if the patient has a family history of gallbladder disease.
- Any patient who presents with profound and sudden anemia and reticulocytopenia with the aforementioned physical findings also should have hereditary spherocytosis in the differential diagnosis.[2]
References
- ↑ Perrotta, Silverio; Gallagher, Patrick G; Mohandas, Narla (2008). "Hereditary spherocytosis". The Lancet. 372 (9647): 1411–1426. doi:10.1016/S0140-6736(08)61588-3. ISSN 0140-6736.
- ↑ Bolton-Maggs PH, Stevens RF, Dodd NJ, Lamont G, Tittensor P, King MJ; et al. (2004). "Guidelines for the diagnosis and management of hereditary spherocytosis". Br J Haematol. 126 (4): 455–74. doi:10.1111/j.1365-2141.2004.05052.x. PMID 15287938.