Non-Hodgkin lymphoma classification: Difference between revisions

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Revision as of 17:33, 14 December 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Non-Hodgkin lymphoma may be classified into subtypes according to updated WHO classification and rate of growth.

Classification

A. Updated WHO classification

Non-Hodgkin lymphoma may be classified according to updated WHO classification into 2 groups:^[1]

B-cell neoplasms
T-cell and putative NK-cell neoplasms

**Updated WHO classification of Non-Hodgkin lymphoma**
B-cell neoplasms	T-cell and putative NK-cell neoplasms
Precursor B-cell neoplasm	Precursor T-cell neoplasm
Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)	Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)
Mature B-cell neoplasms	Peripheral T-cell and NK-cell neoplasms
Chronic lymphocytic leukemia / small lymphocytic lymphoma	T-cell CLL / prolymphocytic leukemia
Monoclonal B-cell lymphocytosis
B-cell prolymphocytic leukemia	T-cell granular lymphocytic leukemia
Splenic marginal zone lymphoma (± villous lymphocytes)	Extranodal T-/NK-cell lymphoma, nasal type
Hairy cell leukemia	Enteropathy-type intestinal T-cell lymphoma
Splenic B-cell lymphoma/leukemia, unclassifiable 1. Splenic diffuse re pulp small B-cell lymphoma 2. Hairy cell leukemia-variant
Lymphoplasmacytic lymphoma Walderstorm macrogloubulinemia	Mycosis fungoides / Sézary syndrome
Monoclonal gammopathy of undetermined significance (MGUS), IgM* 2. IgG/A
µ heavy-chain disease ɣ heavy-chain disease α heavy-chain disease
Plasma cell myeloma (multiple myloma)
Solitary plasmacytoma of bone
Extraosseous plasmacytoma
Mantle cell lymphoma	Peripheral T-cell lymphoma, not otherwise characterized
Follicular lymphoma	Hepatosplenic gamma / delta T-cell lymphoma
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type	Subcutaneous panniculitis-like T-cell lymphoma
Nodal marginal zone B-cell lymphoma (± monocytoid B-cells)	Angioimmunoblastic T-cell lymphoma
Plasmacytoma / plasma cell myeloma	Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
Diffuse large B-cell lymphoma	Anaplastic large cell lymphoma, primary systemic type
Burkitt lymphoma	Anaplastic large cell lymphoma, primary cutaneous type
	Aggressive NK-cell leukemia

B. Classification based on rate of growth

Non-Hodgkin lymphoma may be classified based on rate of growth into 2 groups:^[2]

Low-grade or Indolent lymphoma
High-grade or Aggressive lymphoma

**Non-Hodgkin lymphoma classification**
Grade	Description
Low-grade or Indolent lymphoma	Tend to grow very slowly Tend to be widespread by the time they are diagnosed Often involving the bone marrow and spleen Often treated only when symptoms appear Can shrink or seem to disappear with treatment, but they tend to come back Can change into more aggressive lymphomas Have a fairly good prognosis
High-grade or Aggressive lymphoma	Grow quickly and tend to spread to lymph nodes or other organs throughout the body Cause symptoms and need treatment right away Can frequently be successfully treated with intensive chemotherapy treatment

Non-Hodgkin's Lymphoma

References

↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

Template:Hematology

Template:WikiDoc Sources

[”cancer-1] National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq

[CCS-2] "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

[1]

[2]

@@ Line 20: / Line 20: @@
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Precursor T-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
 |-
-| style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Peripheral B-cell neoplasms
+| style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Mature B-cell neoplasms
 | style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Peripheral T-cell and NK-cell neoplasms
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | B-cell CLL / [[small lymphocytic lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Chronic lymphocytic leukemia]] / [[Chronic lymphocytic leukemia|small lymphocytic lymphoma]]
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | T-cell CLL / prolymphocytic leukemia
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | B-cell prolymphocytic leukemia
+|[[Monoclonal B-cell lymphocytosis]]
+|
+|-
+| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[B-cell prolymphocytic leukemia]]
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[T-cell granular lymphocytic leukemia]]
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Lymphoplasmacytic lymphoma / immunocytoma
+| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)
+| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Extranodal T-/NK-cell lymphoma, nasal type
+|-
+| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Hairy cell leukemia]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Enteropathy-type intestinal T-cell lymphoma]]
+|-
+|Splenic B-cell lymphoma/leukemia, unclassifiable
+. Splenic diffuse re pulp small B-cell lymphoma
+. Hairy cell leukemia-variant
+|
+|-
+| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Lymphoplasmacytic lymphoma
+Walderstorm macrogloubulinemia
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mycosis fungoides]] / [[Sézary syndrome]]
+|-
+|[[Monoclonal gammopathy of undetermined significance]] (MGUS),
+# IgM*
+. IgG/A
+|
+|-
+|µ heavy-chain disease
+ɣ heavy-chain disease
+α heavy-chain disease
+|
+|-
+|[[Multiple myeloma|Plasma cell myeloma]] (multiple myloma)
+|
+|-
+|Solitary plasmacytoma of bone
+|
+|-
+|Extraosseous plasmacytoma
+|
 |-
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mantle cell lymphoma]]
@@ Line 43: / Line 80: @@
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Nodal marginal zone B-cell lymphoma]] (± monocytoid B-cells)
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Angioimmunoblastic T-cell lymphoma
-|-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Extranodal T-/NK-cell lymphoma, nasal type
-|-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Hairy cell leukemia]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Enteropathy-type intestinal T-cell lymphoma]]
 |-
 | style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Plasmacytoma / [[plasma cell myeloma]]

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy

Non-Hodgkin lymphoma classification: Difference between revisions

Revision as of 17:33, 14 December 2018

Overview

Classification

A. Updated WHO classification

B. Classification based on rate of growth

References

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