Carcinoid syndrome historical perspective: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
* Theodor Langhans (1839–1915) was the first to describe the histology of a carcinoid tumor in 1867. | * Theodor Langhans (1839–1915) was the first to describe the histology of a [[carcinoid tumor]] in 1867. | ||
* The term Carcinoid was given by Siegfried Oberndorfer, a German [[pathologist]] at the University of Munich in 1907. | * The term [[Carcinoid]] was given by Siegfried Oberndorfer, a German [[pathologist]] at the University of Munich in 1907. | ||
* Siegfried Oberndorfer refered the carcinoid tumor as "benign carcinomas" as they had distinct clinical entities and named them "karzinoide"(carcinoma-like). | * Siegfried Oberndorfer refered the carcinoid tumor as "benign carcinomas" as they had distinct clinical entities and named them "karzinoide"(carcinoma-like). | ||
* Karzinoide or “carcinoma-like” describes the unique feature of behaving like a benign tumor despite resembling a carcinoma microscopically. | * Karzinoide or “carcinoma-like” describes the unique feature of behaving like a benign [[tumor]] despite resembling a [[carcinoma]] microscopically. | ||
* Rapport and colleagues isolated and named serotonin (5-HT), initially identified as a vasoconstrictor substance in the serum.<ref name="pmid18100415">{{cite journal |vauthors=RAPPORT MM, GREEN AA, PAGE IH |title=Serum vasoconstrictor, serotonin; isolation and characterization |journal=J. Biol. Chem. |volume=176 |issue=3 |pages=1243–51 |date=December 1948 |pmid=18100415 |doi= |url=}}</ref> | * Rapport and colleagues isolated and named serotonin (5-HT), initially identified as a [[vasoconstrictor]] substance in the serum.<ref name="pmid18100415">{{cite journal |vauthors=RAPPORT MM, GREEN AA, PAGE IH |title=Serum vasoconstrictor, serotonin; isolation and characterization |journal=J. Biol. Chem. |volume=176 |issue=3 |pages=1243–51 |date=December 1948 |pmid=18100415 |doi= |url=}}</ref> | ||
* Enterochromaffin | * Enterochromaffin [[Cell|cel]]<nowiki/>l,the cell of origin of [[carcinoid tumour]] had been identified as early as 1897 by N. Kulchitsky (1856-1925). | ||
* F. Lembeck in 1953 established that enterochromaffin cells synthesizes and secretes serotonin and a major hormone responsible for carcinoid syndrome.<ref name="pmid14941051">{{cite journal |vauthors=ERSPAMER V, ASERO B |title=Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine |journal=Nature |volume=169 |issue=4306 |pages=800–1 |date=May 1952 |pmid=14941051 |doi= |url=}}</ref><ref name="pmid16882492">{{cite journal |vauthors=Sippel RS, Chen H |title=Carcinoid tumors |journal=Surg. Oncol. Clin. N. Am. |volume=15 |issue=3 |pages=463–78 |date=July 2006 |pmid=16882492 |doi=10.1016/j.soc.2006.05.002 |url=}}</ref> | * F. Lembeck in 1953 established that enterochromaffin [[cells]] synthesizes and secretes serotonin and a major hormone responsible for [[carcinoid syndrome]].<ref name="pmid14941051">{{cite journal |vauthors=ERSPAMER V, ASERO B |title=Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine |journal=Nature |volume=169 |issue=4306 |pages=800–1 |date=May 1952 |pmid=14941051 |doi= |url=}}</ref><ref name="pmid16882492">{{cite journal |vauthors=Sippel RS, Chen H |title=Carcinoid tumors |journal=Surg. Oncol. Clin. N. Am. |volume=15 |issue=3 |pages=463–78 |date=July 2006 |pmid=16882492 |doi=10.1016/j.soc.2006.05.002 |url=}}</ref> | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Carcinoid syndrome was first described by Siegfried Oberndorfer, a German pathologist in 1907. Endocrine related properties of carcinoid syndrome was described by Gosset and Masson in 1914.[1]
Historical Perspective
- Theodor Langhans (1839–1915) was the first to describe the histology of a carcinoid tumor in 1867.
- The term Carcinoid was given by Siegfried Oberndorfer, a German pathologist at the University of Munich in 1907.
- Siegfried Oberndorfer refered the carcinoid tumor as "benign carcinomas" as they had distinct clinical entities and named them "karzinoide"(carcinoma-like).
- Karzinoide or “carcinoma-like” describes the unique feature of behaving like a benign tumor despite resembling a carcinoma microscopically.
- Rapport and colleagues isolated and named serotonin (5-HT), initially identified as a vasoconstrictor substance in the serum.[2]
- Enterochromaffin cell,the cell of origin of carcinoid tumour had been identified as early as 1897 by N. Kulchitsky (1856-1925).
- F. Lembeck in 1953 established that enterochromaffin cells synthesizes and secretes serotonin and a major hormone responsible for carcinoid syndrome.[3][4]
References
- ↑ Tsoucalas G, Karamanou M, Androutsos G (2011). "The eminent German pathologist Siegfried Oberndorfer (1876-1944) and his landmark work on carcinoid tumors". Ann Gastroenterol. 24 (2): 98–100. PMC 3959292. PMID 24713679.
- ↑ RAPPORT MM, GREEN AA, PAGE IH (December 1948). "Serum vasoconstrictor, serotonin; isolation and characterization". J. Biol. Chem. 176 (3): 1243–51. PMID 18100415.
- ↑ ERSPAMER V, ASERO B (May 1952). "Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine". Nature. 169 (4306): 800–1. PMID 14941051.
- ↑ Sippel RS, Chen H (July 2006). "Carcinoid tumors". Surg. Oncol. Clin. N. Am. 15 (3): 463–78. doi:10.1016/j.soc.2006.05.002. PMID 16882492.