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* Endemic Burkitt's lymphoma <ref name="pmid9454768">{{cite journal| author=Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF| title=Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue. | journal=Blood | year= 1998 | volume= 91 | issue= 4 | pages= 1373-81 | pmid=9454768 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9454768  }} </ref>
* Endemic Burkitt's lymphoma <ref name="pmid9454768">{{cite journal| author=Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF| title=Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue. | journal=Blood | year= 1998 | volume= 91 | issue= 4 | pages= 1373-81 | pmid=9454768 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9454768  }} </ref>
* Sporadic Burkitt's lymphoma<ref name="pmid30042102">{{cite journal| author=Ng JY, Thompson RJ, Lam A, Nigam S| title=Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child. | journal=BMJ Case Rep | year= 2018 | volume= 2018 | issue=  | pages=  | pmid=30042102 | doi=10.1136/bcr-2018-224333 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30042102  }} </ref>
* Sporadic Burkitt's lymphoma<ref name="pmid30042102">{{cite journal| author=Ng JY, Thompson RJ, Lam A, Nigam S| title=Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child. | journal=BMJ Case Rep | year= 2018 | volume= 2018 | issue=  | pages=  | pmid=30042102 | doi=10.1136/bcr-2018-224333 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30042102  }} </ref>
* Immunodeficiency-associated Burkitt's lymphoma
* Immunodeficiency-associated Burkitt's lymphoma<ref name="pmid28506687">{{cite journal| author=Linke-Serinsöz E, Fend F, Quintanilla-Martinez L| title=Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point. | journal=Semin Diagn Pathol | year= 2017 | volume= 34 | issue= 4 | pages= 352-363 | pmid=28506687 | doi=10.1053/j.semdp.2017.04.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28506687  }} </ref>
It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or [[immunophenotype]].  
It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or [[immunophenotype]].  


Revision as of 16:14, 27 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants: endemic Burkitt's lymphoma, sporadic Burkitt's lymphoma, and immunodeficiency-associated Burkitt's lymphoma.

Classification

Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants:

  • Endemic Burkitt's lymphoma [1]
  • Sporadic Burkitt's lymphoma[2]
  • Immunodeficiency-associated Burkitt's lymphoma[3]

It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or immunophenotype.

WHO Classification Based on The Geographic Distribution and Clinical Presentation
Name Description
Endemic Burkitt's lymphoma

(African Burkitt's lymphoma)

Sporadic Burkitt's lymphoma

(Non-African or Non-endemic Burkitt's lymphoma)

  • The most common type of Burkitt's lymphoma in North America and Europe
  • Sometimes associated with the Epstein-Barr virus, but in many cases this virus is not present
  • Non-Hodgkin's lymphoma, which includes Burkitt's, accounts for 30-50% of childhood lymphoma
  • Ileo-cecal region is the common site of involvement
  • Most often starts in the abdomen, but can also start in the ovaries, testicles, kidneys, or other organs
  • Jaw is less commonly involved, comparing with the endemic variant
  • Can also involve the pleura lining the lung, central nervous system (CNS), and uncommonly, the breast
Immunodeficiency-associated Burkitt's lymphoma
  • Tends to occur in people with weakened immune systems, typically those with HIV infection
  • Incidence appears to be dropping due to the development of new antiretroviral therapies
  • About 30–40% of cases are associated with the Epstein-Barr virus

References

  1. ↑ Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF (1998). "Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue". Blood. 91 (4): 1373–81. PMID 9454768.
  2. ↑ Ng JY, Thompson RJ, Lam A, Nigam S (2018). "Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child". BMJ Case Rep. 2018. doi:10.1136/bcr-2018-224333. PMID 30042102.
  3. ↑ Linke-Serinsöz E, Fend F, Quintanilla-Martinez L (2017). "Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point". Semin Diagn Pathol. 34 (4): 352–363. doi:10.1053/j.semdp.2017.04.003. PMID 28506687.

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