Burkitt's lymphoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

The prognosis varies with the age, children have the most favorable prognosis. Burkitt's lymphoma in children is associated with a 5 year survival rate of 90%. The presence of metastasis in bone marrow or CNS is associated with a particularly poor prognosis among patients with Burkitt's lymphoma.

Complications

• Common complications of burkitt's lymphoma include:
  • Disruption of teeth
  • Partial obstruction of airway
  • Ulceration and drianage
  • Tumor lysis syndrome

Prognosis

• In children, prognosis is good with survival rates >90%.
• In adults, prognosis is poor, with a 5-year survival rate of 50% and is even worse with bone marrow or CNS involvement (>30% 5-year survival rate).

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