Sarcomatoid carcinoma of the lung causes: Difference between revisions
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==Overview== | ==Overview== | ||
The direct cause of sarcomatoid carcinoma of the lung is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. | The direct cause of sarcomatoid carcinoma of the lung is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. [[KRAS|K-RAS]]) or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. [[TP53]]) or both. The risk of these genetic mutations may be increased following exposure to environmental components. | ||
==Causes== | ==Causes== | ||
Revision as of 16:39, 3 January 2019
Template:Sarcomatoid carcinoma of the lung causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2]
Overview
The direct cause of sarcomatoid carcinoma of the lung is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both. The risk of these genetic mutations may be increased following exposure to environmental components.
Causes
- The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both.[1][2]
- The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
- To view a comprehensive list of risk factors that increase the risk of lung cancer, click here
References
- ↑ American Cancer Society. Cancer Facts & Figures 2017. Atlanta: American Cancer Society; 2017.
- ↑ Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R (2013). "KRAS mutations in lung cancer". Clin Lung Cancer. 14 (3): 205–14. doi:10.1016/j.cllc.2012.09.007. PMID 23122493.