Hepatocellular adenoma laboratory tests: Difference between revisions
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==Hepatocellular adenoma laboratory tests== | ==Hepatocellular adenoma laboratory tests== | ||
* The hepatocellular adenoma usually have normal liver function tests and no elevation in serum tumor markers, such as alpha fetoprotein. | * The hepatocellular adenoma usually have normal liver function tests and no elevation in serum tumor markers, such as alpha fetoprotein.<ref name="DhingraFiel2014">{{cite journal|last1=Dhingra|first1=Sadhna|last2=Fiel|first2=M. Isabel|title=Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics|journal=Archives of Pathology & Laboratory Medicine|volume=138|issue=8|year=2014|pages=1090–1097|issn=0003-9985|doi=10.5858/arpa.2013-0183-RA}}</ref><ref>{{Cite journal | ||
* The liver function tests may be found abnormal secondary to necrosis or hemorrhage and alkaline phosphatase is raised in patients with hepatocellular adenomatosis (presence of 10 or more hepatocellular adenomas). | | author = [[Paulette Bioulac-Sage]], [[Sandra Rebouissou]], [[Antonio Sa Cunha]], [[Emmanuelle Jeannot]], [[Sebastien Lepreux]], [[Jean-Frederic Blanc]], [[Helene Blanche]], [[Brigitte Le Bail]], [[Jean Saric]], [[Pierre Laurent-Puig]], [[Charles Balabaud]] & [[Jessica Zucman-Rossi]] | ||
| title = Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver | |||
| journal = [[Gastroenterology]] | |||
| volume = 128 | |||
| issue = 5 | |||
| pages = 1211–1218 | |||
| year = 2005 | |||
| month = May | |||
| pmid = 15887105 | |||
}}</ref><ref name="NaultParadis2017">{{cite journal|last1=Nault|first1=Jean-Charles|last2=Paradis|first2=Valérie|last3=Cherqui|first3=Daniel|last4=Vilgrain|first4=Valérie|last5=Zucman-Rossi|first5=Jessica|title=Molecular classification of hepatocellular adenoma in clinical practice|journal=Journal of Hepatology|volume=67|issue=5|year=2017|pages=1074–1083|issn=01688278|doi=10.1016/j.jhep.2017.07.009}}</ref> | |||
* The liver function tests may be found abnormal secondary to necrosis or hemorrhage and alkaline phosphatase is raised in patients with hepatocellular adenomatosis (presence of 10 or more hepatocellular adenomas).<ref>{{Cite journal | |||
| author = [[Massimo Roncalli]], [[Amedeo Sciarra]] & [[Luca Di Tommaso]] | |||
| title = Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma | |||
| journal = [[Clinical and molecular hepatology]] | |||
| volume = 22 | |||
| issue = 2 | |||
| pages = 199–211 | |||
| year = 2016 | |||
| month = June | |||
| doi = 10.3350/cmh.2016.0101 | |||
| pmid = 27189732 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[Ludger Barthelmes]] & [[Iain S. Tait]] | |||
| title = Liver cell adenoma and liver cell adenomatosis | |||
| journal = [[HPB : the official journal of the International Hepato Pancreato Biliary Association]] | |||
| volume = 7 | |||
| issue = 3 | |||
| pages = 186–196 | |||
| year = 2005 | |||
| month = | |||
| doi = 10.1080/13651820510028954 | |||
| pmid = 18333188 | |||
}}</ref> | |||
* The alpha fetoprotein may be raised if patient develops hepatocellualr carcinoma.<ref name=fgh>Clinical and laboratory findings of Hepatic adenoma. Scielo 2015. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202013000300012&lng=en&nrm=iso&tlng=en. Accessed on October 16, 2015</ref> | * The alpha fetoprotein may be raised if patient develops hepatocellualr carcinoma.<ref name=fgh>Clinical and laboratory findings of Hepatic adenoma. Scielo 2015. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202013000300012&lng=en&nrm=iso&tlng=en. Accessed on October 16, 2015</ref> | ||
==References== | ==References== | ||
{{reflist|1}} | {{reflist|1}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]
Overview
The hepatocellular adenoma usually have normal liver function tests and normal serum tumor markers, but may be raised secondary to necrosis or hemorrhage and alkaline phosphatase may be raised in hepatocellular adenomatosis.
Hepatocellular adenoma laboratory tests
- The hepatocellular adenoma usually have normal liver function tests and no elevation in serum tumor markers, such as alpha fetoprotein.[1][2][3]
- The liver function tests may be found abnormal secondary to necrosis or hemorrhage and alkaline phosphatase is raised in patients with hepatocellular adenomatosis (presence of 10 or more hepatocellular adenomas).[4][5]
- The alpha fetoprotein may be raised if patient develops hepatocellualr carcinoma.[6]
References
- ↑ Dhingra, Sadhna; Fiel, M. Isabel (2014). "Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics". Archives of Pathology & Laboratory Medicine. 138 (8): 1090–1097. doi:10.5858/arpa.2013-0183-RA. ISSN 0003-9985.
- ↑ Paulette Bioulac-Sage, Sandra Rebouissou, Antonio Sa Cunha, Emmanuelle Jeannot, Sebastien Lepreux, Jean-Frederic Blanc, Helene Blanche, Brigitte Le Bail, Jean Saric, Pierre Laurent-Puig, Charles Balabaud & Jessica Zucman-Rossi (2005). "Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver". Gastroenterology. 128 (5): 1211–1218. PMID 15887105. Unknown parameter
|month=ignored (help) - ↑ Nault, Jean-Charles; Paradis, Valérie; Cherqui, Daniel; Vilgrain, Valérie; Zucman-Rossi, Jessica (2017). "Molecular classification of hepatocellular adenoma in clinical practice". Journal of Hepatology. 67 (5): 1074–1083. doi:10.1016/j.jhep.2017.07.009. ISSN 0168-8278.
- ↑ Massimo Roncalli, Amedeo Sciarra & Luca Di Tommaso (2016). "Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma". Clinical and molecular hepatology. 22 (2): 199–211. doi:10.3350/cmh.2016.0101. PMID 27189732. Unknown parameter
|month=ignored (help) - ↑ Ludger Barthelmes & Iain S. Tait (2005). "Liver cell adenoma and liver cell adenomatosis". HPB : the official journal of the International Hepato Pancreato Biliary Association. 7 (3): 186–196. doi:10.1080/13651820510028954. PMID 18333188.
- ↑ Clinical and laboratory findings of Hepatic adenoma. Scielo 2015. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202013000300012&lng=en&nrm=iso&tlng=en. Accessed on October 16, 2015